Jianfeng Gong
Nanjing University
Internal medicineEndocrinologyFecal bacteriotherapySurgeryPathologyRetrospective cohort studyInterleukin 10ImmunologyColitisInflammatory bowel diseaseDiseaseCrohn's diseaseUlcerative colitisIn patientMedicineParenteral nutritionBiologyGastroenterologyPharmacology
145Publications
30H-index
2,480Citations
Publications 142
Newest
#1Enhao Wu (NU: Nanjing University)
#2Ming Duan (NU: Nanjing University)H-Index: 1
Last. Weiming Zhu (NU: Nanjing University)H-Index: 32
view all 10 authors...
The incidence and prevalence of Crohn’s disease (CD) are increasing in China, but there are few reports on the characteristics of patients requiring abdominal surgery. This study aimed to evaluate the clinical characteristics of these patients and the potential risk factors for postoperative complications and surgical recurrence. In this observational, retrospective single-center cohort analysis, patients with CD who had undergone at least one abdominal surgery at our center from 2007 to 2020 we...
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#1Tenghui Zhang (NU: Nanjing University)H-Index: 7
Last. Jianfeng Gong (NU: Nanjing University)H-Index: 30
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OBJECTIVE Ulcerative colitis (UC) is an independent risk factor for thromboembolism, especially during the perioperative period. This study aimed to determine the effects of perioperative parenteral nutrition (PN) supplemented with fish oil (FO) on coagulation function and postoperative outcomes in patients with UC. METHODS This retrospective cohort included 92 consecutive patients who underwent colectomy for UC. Postoperative coagulation indices and outcomes, including thromboelastography (TEG)...
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#1Tenghui Zhang (NU: Nanjing University)H-Index: 7
#2Yi Xu (SEU: Southeast University)H-Index: 2
Last. Jianfeng Gong (NU: Nanjing University)H-Index: 30
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BACKGROUND An excessive postoperative inflammatory response is common after surgery for inflammatory bowel disease (IBD) and may be associated with an increased incidence of postoperative ileus. This study assessed the role of perioperative dexamethasone in postoperative ileus after IBD surgery. METHOD Patients undergoing elective IBD surgery were randomized to either an intravenous 8-mg dose of dexamethasone (n = 151) or placebo (n = 151) upon induction of anesthesia. The primary outcome was th...
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INTRODUCTION The mesentery is involved in Crohn's disease. The impact of the extent of mesenteric resection on postoperative disease progression in Crohn's disease remains unconfirmed. This study aimed to determine the association between resection of the mesentery and postoperative outcomes in patients with Crohn's colitis (CC) undergoing colorectal surgery. METHODS Patients with CC who underwent colorectal resection between January 2000 and December 2018 were reviewed, and the data were gather...
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Last. Guo‐xun LiH-Index: 1
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#1Lili Gu (NU: Nanjing University)H-Index: 25
#2Feng Zhu (NU: Nanjing University)H-Index: 74
Last. Ning Li (Tongji University)H-Index: 1
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BACKGROUND This retrospective cohort study from a single center aimed to compare patient outcomes following the use of the water-soluble contrast medium Gastrografin in the treatment of adhesive small bowel obstruction (ASBO) in patients with and without a history of chronic radiation enteropathy (CRE). MATERIAL AND METHODS Fifty-nine patients with CRE-induced small bowel obstruction (SBO) and 53 patients with ASBO at Jinling Hospital between April 2014 and February 2018 were enrolled. The patie...
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#1Yousheng Li (NU: Nanjing University)H-Index: 1
#2Lei Cao (NU: Nanjing University)H-Index: 21
Last. Weiming Zhu (NU: Nanjing University)H-Index: 32
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Objective: To examine the clinical characteristics, the potential relative factors for postoperative abdominal septic complications, and prognosis factors of surgical recurrence of Crohn disease (CD) patients after the first surgery. Methods: All the CD patients from Department of General Surgery, Jinling Hospital, Medical School of Nanjing University who had undergone at least one abdominal surgery from January 2007 to December 2017 were included for retrospective analysis. Hospital records wer...
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#1Weisong Shen (NU: Nanjing University)H-Index: 5
Last. Weiming Zhu (NU: Nanjing University)H-Index: 32
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Background: Prox1 is a transcription factor necessary for lymphatic function. The main aim of the current study was to investigate the potential role of Prox1 in lymphangiogenesis and lymphatic function, and analyze Prox1-dependent stimulation of lymphatic function on mesenteric lesions and the composition of microbiota in Crohn’s disease. Methods: Prox1flox/+, Tie2-CreERT2 and IL-10 KO mice were included. Disease activity and enterocolitis inflammation were assessed using a grading system. Lymp...
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#1Feng Zhu (NU: Nanjing University)H-Index: 1
#2Dengyu Feng (NU: Nanjing University)H-Index: 1
Last. Jianfeng Gong (NU: Nanjing University)H-Index: 30
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BACKGROUND Although the interaction between gut microbiota and pouchitis after ileal pouch anal anastomosis (IPAA) for ulcerative colitis (UC) has been confirmed, evidence of commensal mycobiota in the etiology of pouchitis is still lacking. This study aimed to investigate the role of fungi in the pathogenesis of pouchitis. METHODS Fecal samples were collected from UC patients with or without pouchitis after IPAA. Experimental pouchitis was induced by 5% dextran sulfate sodium for 7 consecutive ...
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#1Ruiqing Liu (NU: Nanjing University)H-Index: 3
#2Shuaihua Qiao (NU: Nanjing University)H-Index: 1
Last. Weiming Zhu (NU: Nanjing University)H-Index: 32
view all 11 authors...
ACKGROUND AND AIMS: The aim of this study was to investigate the metabolic profile of mesenteric adipocytes and the correlations between key metabolic changes and local inflammation in the context of CD. METHODS: Metabolic dysfunction was shown to be regulated by fatty acid desaturase-2 (FADS2) through metabolomics and functional analyses of mesenteric adipose tissue biopsies and primary mesenteric adipocytes isolated from surgical specimens collected from CD patients and control subjects. FADS2...
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