Luis Bujanda
Carlos III Health Institute
CancerInternal medicineSurgeryPathologyOncologyOdds ratioHumanitiesHelicobacter pyloriInflammatory bowel diseaseColonoscopyDiseaseCrohn's diseasePopulationConfidence intervalCancer researchColorectal cancerMedicineCohortBiologyGastroenterology
564Publications
67H-index
11.6kCitations
Publications 571
Newest
Helicobacter pylori infection is very common in the Spanish population and represents the main cause of chronic gastritis, peptic ulcer, and gastric cancer. The last iteration of Spanish consensus guidelines on H. pylori infection was conducted in 2016. Recent changes in therapeutic schemes along with increasing supporting evidence were key for developing the V Spanish Consensus Conference (May 2021). Fourteen experts performed a systematic review of the scientific evidence and developed a serie...
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#1Tomoko Nakanishi (McGill University)H-Index: 5
#2Sara Pigazzini (UH: University of Helsinki)H-Index: 1
Last. Adriana PalomH-Index: 3
view all 47 authors...
Background null There is considerable variability in COVID-19 outcomes amongst younger adults-and some of this variation may be due to genetic predisposition. null Methods null We combined individual level data from 13,888 COVID-19 patients (N=7,185 hospitalized) from 17 cohorts in nine countries to assess the association of the major common COVID-19 genetic risk factor (chromosome 3 locus tagged by rs10490770) with mortality, COVID-19-related complications and laboratory values. We next perform...
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#1Luis G. Guijarro (University of Alcalá)H-Index: 18
#2D. Cano-Martínez (University of Alcalá)H-Index: 2
Last. Laura Sebastián Monasor (University of Alcalá)
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Inflammatory bowel diseases (IBD), represented by ulcerative colitis (UC) and Crohn's disease (CD), are characterized by chronic inflammation of the gastrointestinal tract, what leads to diarrhea, malnutrition, and weight loss. Depression of the growth hormone-insulin-like growth factor-1 axis (GH-IGF-1 axis) could be responsible of these symptoms. We demonstrate that long-term treatment (54 weeks) of adult CD patients with adalimumab (ADA) results in a decrease in serum IGF-1 without changes in...
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ABSTRACT null null Background: COVID-19 pandemic increased medical services demand aside from interrupting daily clinical practice for other diseases such as Inflammatory Bowel Disease (IBD). Here we present the results of a survey to gain the perception of IBD specialists in their patient-management using telemedicine in their daily practice. null Methods: This was an observational survey study among physicians focused on IBD (gastroenterologist, surgeons, and pediatricians) members of the Span...
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#1Luis BujandaH-Index: 67
#2Olga P NyssenH-Index: 8
Last. Antonio GasbarriniH-Index: 104
view all 22 authors...
Background: Bacterial antibiotic resistance changes over time depending on multiple factors; therefore, it is essential to monitor the susceptibility trends to reduce the resistance impact on the effectiveness of various treatments. Objective: To conduct a time-trend analysis of Helicobacter pylori resistance to antibiotics in Europe. Methods: The international prospective European Registry on Helicobacter pylori Management (Hp-EuReg) collected data on all infected adult patients diagnosed with ...
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BACKGROUND Crohn's disease (CD) with upper gastrointestinal involvement (UGI) may have a more aggressive and refractory course. However, evidence on this phenotype of patients is scarce. AIMS To identify the clinical characteristics, therapeutic requirements and complications associated with UGI in CD METHODS: Nationwide study of cases (UGI, UGI plus ileal/ileocolonic involvement) paired with controls (ileal/ileocolonic involvement) from the ENEIDA registry. Cases were matched to 2 controls by y...
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#1Koldo Garcia-Etxebarria (KI: Karolinska Institutet)H-Index: 13
#2Florencia Carbone (Katholieke Universiteit Leuven)H-Index: 14
Last. Sebastian Zöllner (UM: University of Michigan)H-Index: 39
view all 15 authors...
BACKGROUND Functional dyspepsia (FD) is a common gastrointestinal condition of poorly understood pathophysiology. While symptoms' overlap with other conditions may indicate common pathogenetic mechanisms, genetic predisposition is suspected but has not been adequately investigated. METHODS Using healthcare, questionnaire, and genetic data from three large population-based biobanks (UK Biobank, EGCUT, and MGI), we surveyed FD comorbidities, heritability, and genetic correlations across a wide spe...
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#1Maria Caldas (UAM: Autonomous University of Madrid)H-Index: 4
Last. José María HuguetH-Index: 13
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Statins could increase the effectiveness of Helicobacter pylori eradication therapies due to their anti-inflammatory effect. The aim of this study was to analyze the impact of this therapeutic association in real life. This is a multicenter, prospective, non-interventional study aimed at evaluating the management of H. pylori by European gastroenterologists. Patients were registered in an e-CRF by AEG-REDCap from 2013 to 2020. The association between statin use and H. pylori eradication effectiv...
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#1Jesus Garcia-Foncillas (UAM: Autonomous University of Madrid)H-Index: 7
#2Jesús Argente (ISCIII: Carlos III Health Institute)H-Index: 60
Last. José L. Pablos (Complutense University of Madrid)H-Index: 44
view all 11 authors...
Although the concept of precision medicine, in which healthcare is tailored to the molecular and clinical characteristics of each individual, is not new, its implementation in clinical practice has been heterogenous. In some medical specialties, precision medicine has gone from being just a promise to a reality that achieves better patient outcomes. This is a fact if we consider, for example, the great advances made in the genetic diagnosis and subsequent treatment of countless hereditary diseas...
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#1Pui Y. Lee-Law (UPV/EHU: University of the Basque Country)H-Index: 3
#2Paula Olaizola (UPV/EHU: University of the Basque Country)H-Index: 6
Last. Patricia Aspichueta (UPV/EHU: University of the Basque Country)H-Index: 23
view all 14 authors...
Background null Polycystic liver diseases (PLDs) are genetic inherited disorders characterized by the progressive growth of numerous intrahepatic biliary cysts, which are the main cause of morbidity. Previous studies revealed that cystic cholangiocytes are characterized by endoplasmic reticulum stress and aberrant posttranslational modification (PTM) of proteins, in particular hyper-SUMOylation, that promote PLD pathobiology. Protein NEDDylation is a newly characterized PTM that modulates a plet...
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