Hélder A. Santos
University of Helsinki
BiophysicsDrug carrierBiomedical engineeringNanomedicineNanoparticleNanotechnologyNanocarriersChemistryMaterials scienceIn vivoPorous siliconBiocompatibilityDrug deliveryDrugChemical engineeringCancer researchMedicineMicrofluidicsCancer cellPharmacology
1,034Publications
149H-index
50kCitations
Publications 407
Newest
#1Feng Zhang (SJTU: Shanghai Jiao Tong University)H-Index: 24
#2Yiran Zhang (SJTU: Shanghai Jiao Tong University)H-Index: 3
Last. Hélder A. Santos (UH: University of Helsinki)H-Index: 149
view all 15 authors...
Communication between biological components is critical for homeostasis maintenance among the convergence of complicated bio-signals. For therapeutic nanoparticles (NPs), the general lack of effective communication mechanisms with the external cellular environment causes loss of homeostasis, resulting in deprived autonomy, severe macrophage-mediated clearance, and limited tumor accumulation. Here, we develop a multistage signal-interactive system on porous silicon particles through integrating t...
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#1Zehua Liu (UH: University of Helsinki)H-Index: 16
#2Shiqi Wang (UH: University of Helsinki)H-Index: 21
Last. Hélder A. Santos (UH: University of Helsinki)H-Index: 149
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Abstract Ribonucleic acid interference (RNAi) is an innovative treatment strategy for a myriad of indications. Non-viral synthetic nanoparticles (NPs) have drawn extensive attention as vectors for RNAi due to their potential advantages, including improved safety, high delivery efficiency and economic feasibility. However, the complex natural process of RNAi and the susceptible nature of oligonucleotides render the NPs subject to particular design principles and requirements for practical fabrica...
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#1Shiqi WangH-Index: 21
#2Flavia FontanaH-Index: 17
Last. Hélder A. SantosH-Index: 149
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Acetalated dextran (Ac-DEX) is a pH-responsive dextran derivative polymer. Prepared by a simple acetalation reaction, Ac-DEX has tunable acid-triggered release profile. Despite its relatively short research history, Ac-DEX has shown great potential in various therapeutic applications. Furthermore, the recent functionalization of Ac-DEX makes versatile derivatives with additional properties. Herein, we summarize the cutting-edge development of Ac-DEX and related polymers. Specifically, we focus o...
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#1Cláudia Azevedo (University of Porto)H-Index: 8
#2Soraia Pinto (University of Porto)H-Index: 3
Last. Bruno Sarmento (University of Porto)H-Index: 67
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Abstract Diabetes mellitus is a chronic disease with an elevated risk of micro- and macrovascular complications, such as fibrosis. To prevent diabetes-associated fibrosis, the symptomatology of diabetes must be controlled, which is commonly done by subcutaneous injection of antidiabetic peptides. To minimize the pain and distress associated with such injections, there is an urgent need for non-invasive oral transmucosal drug delivery strategies. However, orally administered peptide-based drugs a...
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#1Flavia FontanaH-Index: 17
Last. Hélder A. SantosH-Index: 149
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In vivo models remain a principle screening tool in the drug discovery pipeline. Here, the challenges associated with the need for animal experiments, as well as their impact on research, individual/societal, and economic contexts are discussed. A number of alternatives that, with further development, optimization, and investment, may replace animal experiments are also revised.
2 CitationsSource
#1Yaping Ding (UH: University of Helsinki)H-Index: 18
#2Wei Li (UH: University of Helsinki)H-Index: 26
Last. Hélder A. Santos (UH: University of Helsinki)H-Index: 149
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Abstract Electrospun organic/inorganic hybrid scaffolds have been appealing in tissue regeneration owing to the integrated physicochemical and biological performances. However, the conventional electrospun scaffolds with non-woven structures usually failed to enable deep cell infiltration due to the densely stacked layers among the fibers. Herein, through self-assembly-driven electrospinning, a polyhydroxybutyrate/poly(e-caprolactone)/58S sol-gel bioactive glass (PHB/PCL/58S) hybrid scaffold wit...
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#1Huanhuan LuoH-Index: 1
#2Li Kong (HUST: Huazhong University of Science and Technology)H-Index: 4
Last. Wenguo Cui (SJTU: Shanghai Jiao Tong University)H-Index: 51
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#1Surachet ImlimthanH-Index: 3
Last. Mirkka SarparantaH-Index: 17
view all 9 authors...
Metastatic melanoma can be difficult to detect until at the advanced state that decreases the survival rate of patients. Several FDA-approved BRAF inhibitors have been used for treatment of metastatic melanoma, but overall therapeutic efficacy has been limited. Lutetium-177 (177 Lu) enables simultaneous tracking of tracer accumulation with single-photon emission computed tomography and radiotherapy. Therefore, the codelivery of 177 Lu alongside chemotherapeutic agents using nanoparticles (NPs) m...
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#1Shahla Karimzadeh (SUT: Sahand University of Technology)H-Index: 1
#2Siamak Javanbakht (University of Tabriz)H-Index: 13
Last. Hélder A. Santos (UH: University of Helsinki)H-Index: 149
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Abstract Nanotechnology, as a progressing field of science, is constantly expanding its role in biomedicine by introducing novel nanoplatforms over time. Nanoscaled metal-organic frameworks (NMOFs) are porous hybrid solids made of organic ligands and metal ions that offer a powerful potential to revolutionize traditional nanocarriers due to their tunable structural features, high surface area, adjustable pore size, facile synthesis, biocompatibility, highly versatile composition, and high chemic...
2 CitationsSource
#1Nicola d'Avanzo (Magna Græcia University)H-Index: 4
#2Giulia Torrieri (UH: University of Helsinki)H-Index: 5
Last. Hélder A. Santos (UH: University of Helsinki)H-Index: 149
view all 10 authors...
Abstract Breast cancer, with around 2 million new cases in 2019, is the second most common cancer worldwide and the second leading cause of cancer death among females. The aim of this work is to realize a targeting nanomedicine through the conjugation of LinTT1 peptide, a specific molecule targeting p32 protein overexpressed by breast cancer and cancer associated cells, on liposomes’ surface. This approach increases the cytotoxic effects of doxorubicin (DOX) and sorafenib (SRF) co-loaded in ther...
1 CitationsSource