Nam Nhut Phan
Trường ĐH Nguyễn Tất Thành
GeneDeep learningCardiac function curveTransforming growth factorCancerInternal medicineEndocrinologyWnt signaling pathwaySOX4OncologymicroRNAGene expressionKEGGArtificial intelligenceVirologyGene expression profilingChemistryImmunologyImmunohistochemistryFucoidanLung cancerArseniteCoronavirusMetastasisDiseaseLNCaPGene signatureProstate cancerOncogeneStem cellCell cycleComputer scienceArsenicCancer researchColorectal cancerBreast cancerBiochemistryCarcinogenesisBioinformaticsMedicineBlood pressureEstrogen receptorTranscription factorBiologyImmune systemCancer cellPharmacology
31Publications
11H-index
342Citations
Publications 30
Newest
#1Yen-Hung Wu (KMU: Kaohsiung Medical University)H-Index: 5
#2I-Jeng YehH-Index: 6
Last. Ming Derg Lai (NCKU: National Cheng Kung University)H-Index: 35
view all 11 authors...
Abstract Background Pathogenic coronaviruses include Middle East respiratory syndrome coronavirus (MERS-CoV), severe acute respiratory syndrome coronavirus (SARS-CoV), and SARS-CoV-2. These viruses have induced outbreaks worldwide, and there are currently no effective medications against them. Therefore, there is an urgent need to develop potential drugs against coronaviruses. Methods High-throughput technology is widely used to explore differences in messenger (m)RNA and micro (mi)RNA expressio...
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#1Li-Chin ChengH-Index: 2
#2Tzu Jen Kao (TMU: Taipei Medical University)H-Index: 1
Last. Hui Ping Hsu (NCKU: National Cheng Kung University)H-Index: 20
view all 11 authors...
ABSTRACT: Severe acute respiratory syndrome coronavirus (SARS-CoV)-2 induces severe infection, and it is responsible for a worldwide disease outbreak starting in late 2019. Currently, there are no effective medications against coronavirus. In the present study, we utilized a holistic bioinformatics approach to study gene signatures of SARS-CoV- and SARS-CoV-2-infected Calu-3 lung adenocarcinoma cells. Through the Gene Ontology platform, we determined that several cytokine genes were up-regulated...
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#1Pin Shern Chen (CNU: Chia Nan University of Pharmacy and Science)H-Index: 1
#2Hui Ping Hsu (NCKU: National Cheng Kung University)H-Index: 20
Last. Pei-Hsiang Yeh (CNU: Chia Nan University of Pharmacy and Science)H-Index: 1
view all 17 authors...
According to cancer statistics reported in 2020, breast cancer constitutes 30% of new cancer cases diagnosed in American women. Histological markers of breast cancer are expressions of the estrogen receptor (ER), the progesterone receptor (PR), and human epidermal growth factor receptor (HER)-2. Up to 80% of breast cancers are grouped as ER-positive, which implies a crucial role for estrogen in breast cancer development. Therefore, identifying potential therapeutic targets and investigating thei...
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#1Chih-Yang WangH-Index: 9
#2Ying Jui Chao (NCKU: National Cheng Kung University)H-Index: 8
Last. Ming Derg LaiH-Index: 35
view all 8 authors...
Ampullary cancer is a rare periampullary cancer currently with no targeted therapeutic agent. It is important to develop a deeper understanding of the carcinogenesis of ampullary cancer. We attempted to explore the characteristics of ampullary cancer in our dataset and a public database, followed by a search for potential drugs. We used a bioinformatics pipeline to analyze complementary (c)DNA microarray data of ampullary cancer and surrounding normal duodenal tissues from five patients. A publi...
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#1Yen-Hung WuH-Index: 5
#2I-Jeng YehH-Index: 6
Last. Hui Ping HsuH-Index: 20
view all 7 authors...
Highly pathogenic coronaviruses (CoVs) induce acute respiratory distress syndrome, and the severe acute respiratory syndrome coronavirus (SARS-CoV)-2 has caused a pandemic since late 2019. The diversity of clinical manifestations after SARS-CoV-2 infection results in great challenges to diagnose CoV disease 2019 (COVID-19). There is a growing body of published research on this topic; however, effective medications are still undergoing a long process of being assessed. In the search for potential...
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#1Nam Nhut PhanH-Index: 11
Last. Mong-Hsun TsaiH-Index: 28
view all 4 authors...
Source
#1Hsin-Liang Liu (KMU: Kaohsiung Medical University)H-Index: 1
#2I-Jeng Yeh (KMU: Kaohsiung Medical University)H-Index: 6
Last. Ming Derg Lai (NCKU: National Cheng Kung University)H-Index: 35
view all 13 authors...
Coronaviruses (CoVs) consist of six strains, and the severe acute respiratory syndrome coronavirus (SARS-CoV), newly found coronavirus (SARS-CoV-2) has rapidly spread leading to a global outbreak. The ferret (Mustela putorius furo) serves as a useful animal model for studying SARS-CoV/SARS-CoV-2 infection and developing therapeutic strategies. A holistic approach for distinguishing differences in gene signatures during disease progression is lacking. The present study discovered gene expression ...
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#1Chung-Che WuH-Index: 2
#2Titus Ime Ekanem (UNIUYO: University of Uyo)H-Index: 2
Last. Chih-Yang Wang (TMU: Taipei Medical University)H-Index: 9
view all 7 authors...
Breast cancer is the most common cancer type in females, and exploring the mechanisms of disease progression is playing a crucial role in the development of potential therapeutics. Pituitary tumor-transforming gene (PTTG) family members are well documented to be involved in cell-cycle regulation and mitosis, and contribute to cancer development by their involvement in cellular transformation in several tumor types. The critical roles of PTTG family members as crucial transcription factors in div...
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#1Li-Chin ChengH-Index: 2
#2Ying Jui Chao (NCKU: National Cheng Kung University)H-Index: 8
Last. Ming Derg Lai (NCKU: National Cheng Kung University)H-Index: 35
view all 10 authors...
Ampullary adenocarcinoma is a rare gastrointestinal cancer in which WNT signalling dysregulation has been previously reported. Secreted frizzled related protein 1 (SFRP1) is one of the extracellular ligands of WNT signalling. We performed bioinformatics analyses of SFRP1 expression in human cancer. Microarray analysis of SFRP1 in periampullary adenocarcinoma was obtained from the Gene Expression Omnibus GSE39409 dataset. SFRP1 expression in ampullary adenocarcinoma was detected by immunohistoche...
Source
#1Li-Chin ChengH-Index: 2
#2Ying Jui Chao (NCKU: National Cheng Kung University)H-Index: 8
Last. Ming Derg Lai (NCKU: National Cheng Kung University)H-Index: 35
view all 10 authors...
Purpose Tumor-associated macrophages (TAMs) originate from monocytes and differentiate into mature macrophages. The interaction between cancer cells and TAMs promotes tumor growth and suppresses immunosurveillance. However, this phenomenon has seldom been observed in ampullary cancer. Patients and methods TAMs in ampullary cancer were investigated using immunohistochemical (IHC) staining of cancer tissues. Bioinformatic analysis of data from the Gene Expression Omnibus (GEO) database revealed tr...
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