Rachel M. Williamson
Western General Hospital
Internal medicineEndocrinologyPathologyUltrasoundRenal functionPhysical therapyProspective cohort studyCohort studySteatosisLiver diseaseType 2 diabetesCirrhosisFatty liverChronic liver diseaseDiseaseFibrosisPopulationType 2 Diabetes MellitusHepatic fibrosisRisk factorLiver function testsDiabetes mellitusMedicineGastroenterology
37Publications
11H-index
572Citations
Publications 37
Newest
#1Sheila M. Grecian (Edin.: University of Edinburgh)H-Index: 2
#2Stela McLachlan (Edin.: University of Edinburgh)H-Index: 25
Last. Mark W. J. Strachan (Western General Hospital)H-Index: 46
view all 13 authors...
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#1Sheila M. Grecian (Edin.: University of Edinburgh)H-Index: 2
#2Stela McLachlan (Edin.: University of Edinburgh)H-Index: 14
Last. Mark W. J. Strachan (Western General Hospital)H-Index: 46
view all 14 authors...
BACKGROUND The incidence of cirrhosis and hepatocellular carcinoma (HCC) is increased in Type 2 diabetes, primarily secondary to non-alcoholic fatty liver disease (NAFLD). European guidelines recommend screening for NAFLD in Type 2 diabetes. American guidelines, while not advocating a screening protocol, suggest using non-invasive markers of fibrosis for risk-stratification and guiding onward referral. AIMS To test the ability of individual fibrosis scores and the European screening algorithm to...
5 CitationsSource
#1Sheila M. GrecianH-Index: 2
Last. Rachel M. WilliamsonH-Index: 11
view all 6 authors...
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#1Sara J. JenksH-Index: 6
#2Bryan R. Conway (BHF: British Heart Foundation)H-Index: 17
Last. Jackie F. Price (Edin.: University of Edinburgh)H-Index: 62
view all 10 authors...
Aims/hypothesis We investigated whether biochemical cardiovascular risk factors and/or markers of subclinical cardiovascular disease were associated with the development of reduced renal function in people with type 2 diabetes.
6 CitationsSource
#1Joanne R Morling (Edin.: University of Edinburgh)H-Index: 16
#2Jonathan A. Fallowfield (Edin.: University of Edinburgh)H-Index: 24
Last. Jackie F. Price (Edin.: University of Edinburgh)H-Index: 62
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Background: Type 2 diabetes is an independent risk factor for chronic liver disease, however disease burden estimates and knowledge of prognostic indicators are lacking in community populations. Aims: To describe the prevalence and incidence of clinically significant chronic liver disease amongst community-based older people with Type 2 diabetes and to determine risk factors which might assist in discriminating patients with unknown prevalent or incident disease. Design: Prospective cohort study...
9 CitationsSource
#1Joanne R MorlingH-Index: 16
Last. Jackie F. PriceH-Index: 62
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#1Rebecca M. ReynoldsH-Index: 64
#2Javier LabadH-Index: 25
Last. Brian R. WalkerH-Index: 92
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Objective: Both type 2 diabetes and glucocorticoid therapy are highly prevalent. Although people with type 2 diabetes may be more susceptible to adverse effects of glucocorticoids, and it is recommended that glucocorticoid therapy is avoided for fear of worsening glycaemic control, the extent to which this advice is followed and the consequences when glucocorticoids are prescribed are poorly documented. The aim was to assess the characteristics of people with type 2 diabetes prescribed glucocort...
#1Joanne R MorlingH-Index: 16
#2Jonathan A. Fallowfield (Edin.: University of Edinburgh)H-Index: 24
Last. Jenna Price (Edin.: University of Edinburgh)H-Index: 5
view all 8 authors...
Introduction Patients with chronic liver disease (CLD) and, in particular, non-alcoholic fatty liver disease (NAFLD) are known to have both higher all-cause mortality and cardiovascular (CV) mortality rates than the general population. Beyond investigation of GGT there has been little exploration of the relationship between CV disease (CVD) and other markers of liver disease (non-specific liver injury, steatosis, steatohepatitis, liver fibrosis or portal hypertension). We examined the associatio...
Source
#1Joanne R Morling (Edin.: University of Edinburgh)H-Index: 16
#2Jonathan A. Fallowfield (Edin.: University of Edinburgh)H-Index: 24
Last. Jackie F. Price (Edin.: University of Edinburgh)H-Index: 62
view all 8 authors...
Aims/hypothesis We examined the association of prevalent and incident cardiovascular disease (CVD) with chronic liver disease in a cohort of community-based people with type 2 diabetes, in order to clarify the relationship between these two important conditions.
12 CitationsSource
#1Joanne R Morling (Edin.: University of Edinburgh)H-Index: 16
#2Jonathan A. Fallowfield (Edin.: University of Edinburgh)H-Index: 24
Last. Jackie F. Price (Edin.: University of Edinburgh)H-Index: 62
view all 11 authors...
Background & Aims Type 2 diabetes is an established risk factor for the presence and progression of fatty liver. Little is known about the distributions and correlates of hepatic non-invasive biomarkers in community-based populations with diabetes, unselected for liver disease. We aimed to identify the distribution of, and metabolic risk factors associated with serum cytokeratin-18 (CK18) and the Enhanced Liver Fibrosis score (ELF), in a large, representative cohort of people with type 2 diabete...
7 CitationsSource