Masahiko Watanabe
Hokkaido University
Excitatory postsynaptic potentialInternal medicineSynapseEndocrinologyMolecular biologyAMPA receptorNeuroscienceReceptorInhibitory postsynaptic potentialChemistryPostsynaptic potentialNeurotransmissionPurkinje cellCerebellumBiochemistryGlutamate receptorNMDA receptorMedicineBiologyCell biology
Publications 867
#1Izumi Kaji (VUMC: Vanderbilt University Medical Center)H-Index: 16
#2Joseph T. Roland (VUMC: Vanderbilt University Medical Center)H-Index: 21
Last. James R. Goldenring (Vandy: Vanderbilt University)H-Index: 83
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Functional loss of MYO5B induces a variety of deficits in intestinal epithelial cell function and causes a congenital diarrheal disorder, microvillus inclusion disease (MVID). The impact of MYO5B loss on differentiated cell lineage choice has not been investigated. We quantified the populations of differentiated epithelial cells in tamoxifen-induced epithelial-specific MYO5B knockout (VilCreERT2;Myo5bflox/flox) mice utilizing digital image analysis. Consistent with our RNA-sequencing data, MYO5B...
#1Esther S.K. Lai (UTokyo: University of Tokyo)H-Index: 1
#2Hisako NakayamaH-Index: 8
Last. Masanobu Kano (UTokyo: University of Tokyo)H-Index: 91
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Neuroligin is a postsynaptic cell-adhesion molecule that is involved in synapse formation and maturation by interacting with presynaptic neurexin. Mutations in neuroligin genes, including the arginine to cystein substitution at the 451st amino acid residue (R451C) of neuroligin-3 (NLGN3), have been identified in patients with autism spectrum disorder (ASD). Functional magnetic resonance imaging and examination of post-mortem brain in ASD patients implicate alteration of cerebellar morphology and...
Abstract null null The cerebellum is essential for the control, coordination, and learning of movements, and for certain aspects of cognitive function. Purkinje cells are the sole output neurons in the cerebellar cortex and therefore play crucial roles in the diverse functions of the cerebellum. The type 1 metabotropic glutamate receptor (mGluR1) is prominently enriched in Purkinje cells and triggers downstream signaling pathways that are required for functional and structural plasticity, and fo...
#1Tomoyasu Noji (Nagoya Institute of Technology)H-Index: 6
#2Mai Watanabe (UTokyo: University of Tokyo)H-Index: 12
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Phycobilisomes (PBSs) are photosynthetic antenna megacomplexes comprised of pigment-binding proteins (cores and rods) joined with linker proteins. A rod-type PBS that does not have a core is connected to photosystem I (PSI) by a pigment-free CpcL linker protein, which induces a red-shift of the absorption band of phycocyanobilin (PCB) in the rod (red-PCB). Herein, the isolated supercomplex of the rod-type PBS and the PSI tetramer from Anabaena sp. PCC 7120 were probed by picosecond laser spectro...
#1Taisuke Miyazaki (Hokkaido University)H-Index: 35
#2Miwako Yamasaki (Hokkaido University)H-Index: 30
Last. Masahiko Watanabe (Hokkaido University)H-Index: 122
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Abstract Purkinje cells (PCs) are principal cerebellar neurons, and several classes of interneurons modulate their activity. Lugaro cells (LCs) are one such inhibitory interneuron with distinctive cytology and location, but still most enigmatic among cerebellar neurons. Here we serendipitously produced a novel transgenic mouse line, where a half of Yellow Cameleon (YC)(+) cells in the cerebellar cortex were judged to be LCs, and YC(+) LCs were estimated to constitute one-third of the total LC po...
2 CitationsSource
#1Ramos Cc (Albert Einstein College of Medicine)
#2Stefano Lutzu (Albert Einstein College of Medicine)H-Index: 5
Last. Pablo E. Castillo (Albert Einstein College of Medicine)H-Index: 56
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Mossy cells (MCs) of the dentate gyrus (DG) are key components of an excitatory associative circuit established by reciprocal connections with dentate granule cells (GCs). MCs are implicated in place field encoding, pattern separation and novelty detection, as well as in brain disorders such as temporal lobe epilepsy and depression. Despite their functional relevance, little is known about the determinants that control MC activity. Here, we examined whether MCs express functional kainate recepto...
#1Izumi KajiH-Index: 16
#2Joseph T. RolandH-Index: 21
Last. James R. GoldenringH-Index: 83
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#1Shigeto Sato (Juntendo University)H-Index: 26
#2Sachiko Noda (Juntendo University)H-Index: 5
Last. Nobutaka Hattori (Juntendo University)H-Index: 95
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Inactivation of constitutive autophagy results in the formation of cytoplasmic inclusions in neurons, but the relationship between impaired autophagy and Lewy bodies (LBs) remains unknown. α-Synuclein and p62, components of LBs, are the defining characteristic of Parkinson's disease (PD). Until now, we have analyzed mice models and demonstrated p62 aggregates derived from an autophagic defect might serve as 'seeds' and can potentially be cause of LBs formation. P62 may be the key molecule for ag...
1 CitationsSource