Carla Molteni
King's College London
SuperlatticeBinding siteSemiconductorHydrogen bondEnergy landscapeBiophysicsComputational chemistryDensity functional theoryChemical physicsNanotechnologyTight bindingAb initio quantum chemistry methodsChemistryMaterials scienceCondensed matter physicsAb initioRaman spectroscopyMolecular physicsIon channelMolecular dynamicsMetadynamicsStereochemistryLigand-gated ion channel
83Publications
22H-index
1,179Citations
Publications 81
Newest
#1Aurimas Vyšniauskas (Imperial College London)H-Index: 14
#2Bethan Cornell ('KCL': King's College London)H-Index: 2
Last. Marina K. Kuimova (Imperial College London)H-Index: 38
view all 11 authors...
A quantitative fluorescent probe that responds to changes in temperature is highly desirable for studies of biological environments, particularly in cellulo. Here, we report new cell-permeable fluorescence probes based on the BODIPY moiety that respond to environmental temperature. The new probes were developed on the basis of a well-established BODIPY-based viscosity probe by functionalization with cyclopropyl substituents at α and β positions of the BODIPY core. In contrast to the parent BODIP...
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#1Alessandro Crnjar ('KCL': King's College London)H-Index: 3
#2Susanne M. Mesoy (University of Cambridge)H-Index: 2
Last. Carla Molteni ('KCL': King's College London)H-Index: 22
view all 4 authors...
Pentameric ligand-gated ion channels (pLGICs) mediate fast synaptic transmission and are crucial drug targets. Their gating mechanism is triggered by ligand binding in the extracellular domain that culminates in the opening of a hydrophobic gate in the transmembrane domain. This domain is made of four α-helices (M1 to M4). Recently the outer lipid-facing helix (M4) has been shown to be key to receptor function, however its role in channel opening is still poorly understood. It could act through ...
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#1Hossein Yadegari (Imperial College London)H-Index: 2
#1Hossein Yadegari (Imperial College London)H-Index: 2
Last. Mary P. Ryan (Imperial College London)H-Index: 45
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Despite their ubiquitous usage and increasing societal dependence on Li-ion batteries, there remains a lack of detailed empirical evidence of Li intercalation/deintercalation into graphite even tho...
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#1Yurema Teijeiro-Gonzalez ('KCL': King's College London)H-Index: 1
#2Alessandro Crnjar ('KCL': King's College London)H-Index: 3
Last. Jakub NedbalH-Index: 9
view all 8 authors...
Abstract Forster resonance energy transfer (FRET) is a powerful tool to investigate the interaction between proteins in living cells. Fluorescence proteins, such as the green fluorescent protein (GFP) and its derivatives, are co-expressed in cells linked to proteins of interest. Time-resolved fluorescence anisotropy is a popular tool to study homo-FRET of fluorescent proteins as an indicator of dimerisation, where its signature consists of a very short component at the beginning of the anisotrop...
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#1Maria Celeste Maschio (University of Modena and Reggio Emilia)H-Index: 1
#2Jacopo Fregoni (UNIPD: University of Padua)H-Index: 4
Last. Stefano Corni (UNIPD: University of Padua)H-Index: 26
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The protein β2-microglobulin (β2-m) can aggregate in insoluble amyloid fibrils, which deposit in the skeletal muscle system of patients undergoing long-term haemodialysis. The molecular mechanisms of such amyloidogenesis are still not fully understood. A potential, although debated, triggering factor is the cis to trans isomerization of a specific proline (Pro32) in β2-m. Here we investigate this process in the native protein and in the aggregation-prone mutant D76N by means of molecular dynamic...
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#1Alessandro Crnjar ('KCL': King's College London)H-Index: 3
#2Carla Molteni ('KCL': King's College London)H-Index: 22
Pentameric ligand-gated ion channels (pLGICs), embedded in the lipid membranes of nerve cells, mediate fast synaptic transmission and are major pharmaceutical targets. Because of their complexity and the limited knowledge of their structure, their working mechanisms have still to be fully unraveled at the molecular level. Over the past few years, evidence that the lipid membrane may modulate the function of membrane proteins, including pLGICs, has emerged. Here, we investigate, by means of molec...
1 CitationsSource
#1I. Emilie Steinmark ('KCL': King's College London)H-Index: 2
#2Pei-Hua Chung ('KCL': King's College London)H-Index: 11
Last. Klaus Suhling ('KCL': King's College London)H-Index: 41
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Understanding viscosity in complex environments remains a largely unanswered question despite its importance in determining reaction rates in vivo. Here, time-resolved fluorescence anisotropy imaging (TR-FAIM) is combined with fluorescent molecular rotors (FMRs) to simultaneously determine two non-equivalent viscosity-related parameters in complex heterogeneous environments. The parameters, FMR rotational correlation time and lifetime, are extracted from fluorescence anisotropy decays, which in ...
4 CitationsSource
#1Alessandro Crnjar ('KCL': King's College London)H-Index: 3
#2Federico ComitaniH-Index: 8
Last. Carla Molteni ('KCL': King's College London)H-Index: 22
view all 4 authors...
Pentameric ligand-gated ion channels (pLGICs) are an important class of widely expressed membrane neuroreceptors, which play a crucial role in fast synaptic communications and are involved in several neurological conditions. They are activated by the binding of neurotransmitters, which trigger the transmission of an electrical signal via facilitated ion flux. They can also be activated, inhibited or modulated by a number of drugs. Mutagenesis electrophysiology experiments, with natural or unnatu...
5 CitationsSource
#1Maxwell Fulford ('KCL': King's College London)H-Index: 1
#2Matteo Salvalaglio (UCL: University College London)H-Index: 20
Last. Carla Molteni ('KCL': King's College London)H-Index: 22
view all 3 authors...
Computer simulation studies of multiphase systems rely on the accurate identification of local molecular structures and arrangements in order to extract useful insights. Local order parameters, such as Steinhardt parameters, are widely used for this identification task; however, the parameters are often tailored to specific local structural geometries and generalize poorly to new structures and distorted or undercoordinated bonding environments. Motivated by the desire to simplify the process an...
9 CitationsSource
#1Klaus SuhlingH-Index: 41
#2Yurema Teijeiro-Gonzalez ('KCL': King's College London)H-Index: 1
Last. Carla Molteni ('KCL': King's College London)H-Index: 22
view all 20 authors...
Imaging viscosity and its spatiotemporal patterns can provide valuable insight into the underlying physical conditions of biochemical reactions and biological processes in cells and tissues. One way to measure viscosity and diffusion is the use of fluorescence recovery after photobleaching (FRAP). We combine FRAP with FLIM and time-resolved fluorescence anisotropy imaging (tr-FAIM), by acquiring time- and polarization-resolved fluorescence images in every frame of a FRAP series. This allows us t...
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