Philip A. Wolf
Boston University
EpidemiologyFramingham Heart StudyFramingham Risk ScoreInternal medicineSurgeryHyperintensityCardiologyPhysical therapyCohort studyHazard ratioDiseaseAtrial fibrillationDementiaPopulationRisk factorStrokeMedicineCohortGerontologyBlood pressure
497Publications
146H-index
95.2kCitations
Publications 522
Newest
#1Jinlei Li (BU: Boston University)H-Index: 3
#2Matthew Ogrodnik (BU: Boston University)H-Index: 3
Last. Rhoda AuH-Index: 63
view all 6 authors...
Abstract Introduction With a rapidly aging population, general practitioners are confronting the challenge of how to determine those who are at greatest risk for dementia and potentially need more specialized follow-up to mitigate symptoms early in its course. We created a practical dementia risk score and provided individualized estimates of future dementia risk. Methods Using the Framingham Heart Study data, we built our prediction model using Cox proportional hazard models and developed a poi...
19 CitationsSource
#1Katherine J. Bangen (UCSD: University of California, San Diego)H-Index: 25
#2Sarah R. Preis (BU: Boston University)H-Index: 29
Last. Adam M. Brickman (Columbia University)H-Index: 53
view all 9 authors...
INTRODUCTION: We examined associations between magnetic resonance imaging (MRI) markers of cerebrovascular disease and neurodegeneration with mild cognitive impairment (MCI) diagnosis at baseline and conversion from normal cognition to MCI at follow-up. METHODS: Framingham Offspring participants underwent brain MRI and neuropsychological assessment at baseline (n=1049) and follow-up (n=561). Participants were classified at baseline and at follow-up as cognitively normal or MCI using sensitive ne...
25 CitationsSource
#1Hugo J. Aparicio (BU: Boston University)H-Index: 13
#2Rodica E. Petrea (Creighton University)H-Index: 4
Last. Sudha Seshadri (BU: Boston University)H-Index: 95
view all 13 authors...
Abstract Background and aims Aortic atherosclerosis is an aggregate marker of vascular risk factor exposure and has been associated with intracranial atherosclerosis and stroke. We hypothesized that atherosclerosis of the descending aorta (DAo) could be a risk marker for brain aging and injury. Methods We evaluated 1527 participants (mean age 59.9 years, 53.5% women) in the Framingham Offspring cohort who underwent both aortic and brain MRI. Participants were free of clinical stroke, dementia, o...
5 CitationsSource
#1Hugo J. Aparicio (BU: Boston University)H-Index: 13
#2Jayandra J. Himali (BU: Boston University)H-Index: 32
Last. Sudha Seshadri (BU: Boston University)H-Index: 95
view all 8 authors...
BackgroundWe investigated how body weight affects survival after stroke, leveraging the availability of multiple prestroke body mass index (BMI) measurements and using a nested case‐control design ...
18 CitationsSource
#1Jinlei LiH-Index: 3
#2Matthew OgrodnikH-Index: 3
Last. Rhoda AuH-Index: 63
view all 6 authors...
Introduction With a rapidly aging population, general practitioners are confronting the challenge of how to determine those who are at greatest risk for dementia and potentially need more specialized follow-up to mitigate symptoms early in its course. We created a practical dementia risk score and provided individualized estimates of future dementia risk.
13 CitationsSource
#1Carole Dufouil (French Institute of Health and Medical Research)H-Index: 59
#2Alexa Beiser (BU: Boston University)H-Index: 94
Last. Sudha Seshadri (BU: Boston University)H-Index: 95
view all 21 authors...
Background: Age-adjusted stroke incidence has decreased over the past 50 years, likely as a result of changes in the prevalence and impact of various stroke risk factors. An updated version of the Framingham Stroke Risk Profile (FSRP) might better predict current risks in the FHS (Framingham Heart Study) and other cohorts. We compared the accuracy of the standard (old) and of a revised (new) version of the FSRP in predicting the risk of all-stroke and ischemic stroke and validated this new FSRP ...
53 CitationsSource
#1Jose R. Romero (BU: Boston University)H-Index: 45
#2Sarah R. Preis (BU: Boston University)H-Index: 29
Last. Sudha Seshadri (BU: Boston University)H-Index: 95
view all 10 authors...
Background and Purpose— Cerebral microbleeds (CMB) represent a common magnetic resonance imaging marker of cerebral small vessel disease, increasingly recognized as a subclinical marker of stroke and dementia risk. CMB detection may reflect the cumulative effect of vascular risk burden and be a marker of higher mortality. We investigated the relation of CMB to risk of death in community dwelling participants free of stroke and dementia. Methods— We evaluated 1963 Framingham Original and Offsprin...
10 CitationsSource
#1Wei Qiao Qiu (BU: Boston University)H-Index: 26
#2Jayandra J. Himali (BU: Boston University)H-Index: 32
Last. Rhoda Au (BU: Boston University)H-Index: 63
view all 6 authors...
Background It is unclear whether brain white matter hyperintensities (WMHI) causes or is a result of late life depression. We used the Framingham Heart Study offspring to examine whether indices of brain aging are related to incident depression in the elderly. Methods The Center for Epidemiologic Studies Depression Scale (CES-D) was administered along with a brain MRI scan at baseline and was re-administered (n = 1212) at an average 6.6 + 0.6 year follow-up. The outcomes (i) change in CES-D scor...
11 CitationsSource
#1Steven A. Lubitz (Harvard University)H-Index: 52
#2Xiaoyan Yin (BU: Boston University)H-Index: 30
Last. Emelia J. BenjaminH-Index: 160
view all 12 authors...
Background and Purpose— To prevent strokes that may occur as the first manifestation of atrial fibrillation (AF), screening programs have been proposed to identify patients with undiagnosed AF who may be eligible for treatment with anticoagulation. However, the frequency with which patients with AF present with stroke as the initial manifestation of the arrhythmia is unknown. Methods— We estimated the frequency with which AF may present as a stroke in 1809 community-based Framingham Heart Study ...
21 CitationsSource
#1Zaldy S. TanH-Index: 18
#2Sudha SeshadriH-Index: 95
Last. Philip A. WolfH-Index: 146
view all 7 authors...
Background: Previous studies examining the association of plasma cholesterol levels with the risk for development of Alzheimer disease (AD) have been inconclusive. We examined the impact of baseline and lifetime plasma total cholesterol levels averaged across many years on the risk for AD in a large, population-based cohort. Methods: Five thousand two hundred nine subjects from the Framingham Study original cohort underwent biennial evaluation for cardiovascular risk factors since 1950, with est...
2 Citations
12345678910
Close Researchers