Laurie B. Joseph
Rutgers University
Internal medicineEndocrinologyPathologyDNA damageMolecular biologyChemistryImmunologyOxidative stressInflammationNitric oxide synthaseDermisLungNitrogen mustardHairlessMacrophageWound healingSulfur mustardToxicityMouse skinScavenger receptorEndocannabinoid systemBiochemistryMedicineBiologyCell biologyPharmacology
Publications 47
#1Laurie B. Joseph (RU: Rutgers University)H-Index: 12
#2Marion K. Gordon (RU: Rutgers University)H-Index: 21
Last. Jeffrey D. Laskin (RU: Rutgers University)H-Index: 69
view all 8 authors...
Sulfur mustard (SM; bis (2-chloroethyl) sulfide) is a potent vesicant which causes irritation of the conjunctiva and damage to the cornea. In the present studies, we characterized the ocular effects of SM in New Zealand white rabbits. Within one day of exposure to SM, edema and hazing of the cornea were observed, followed by neovascularization which persisted for at least 28 days. This was associated with upper and lower eyelid edema and conjunctival inflammation. The conjunctiva is composed of ...
#1Maryam Honarbakhsh (RU: Rutgers University)H-Index: 1
#2Aaron C. Ericsson (MU: University of Missouri)H-Index: 21
Last. Loredana Quadro (RU: Rutgers University)H-Index: 30
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Lecithin:retinol acyltransferase (LRAT) and retinol-binding protein (RBP) enable vitamin A storage and transport, respectively, maintaining tissue homeostasis of retinoids (vitamin A derivatives). The precarious vitamin A status of the Lrat-/-Rbp-/- mice rapidly deteriorates upon dietary vitamin A restriction, leading to signs of severe vitamin A deficiency (VAD). As retinoids impact gut morphology and functions, VAD is often linked to intestinal pathological conditions and microbial dysbiosis. ...
1 CitationsSource
#1Jeffrey D. Laskin (RU: Rutgers University)H-Index: 69
#1Jeffrey D. Laskin (RU: Rutgers University)H-Index: 1
Last. Laurie B. Joseph (RU: Rutgers University)H-Index: 12
view all 7 authors...
Abstract Sulfur mustard (SM), a dermal vesicant that has been used in chemical warfare, causes inflammation, edema and epidermal erosions depending on the dose and time following exposure. Herein, a minipig model was used to characterize wound healing following dermal exposure to SM. Saturated SM vapor caps were placed on the dorsal flanks of 3-month-old male Gottingen minipigs for 30 min. After 48 h the control and SM wounded sites were debrided daily for 7 days with wet to wet saline gauze soa...
1 CitationsSource
#1Christophe Guillon (Lehigh University)H-Index: 8
#2Anna M. Vetrano (RU: Rutgers University)H-Index: 15
Last. Jeffrey D. Laskin (RU: Rutgers University)H-Index: 1
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Abstract A set of 4-(R2-imino)-3-mercapto-5-(R1)-4H-1,2,4-triazoles derivatives were synthesized, characterized and evaluated for their ability to inhibit nitric oxide (NO) production in PAM212 mouse keratinocytes, which led to the discovery and the subsequent evaluation of their growth inhibitory cytotoxic potency toward that same mouse cell line together with a number of human cells lines (PC3, HT-29 and HeLa). Some limited SAR could be established for both NO production inhibition potency and...
2 CitationsSource
#1Mingxing Huang (SYSU: Sun Yat-sen University)H-Index: 4
#2Bo Kong (RU: Rutgers University)H-Index: 22
Last. Grace L. Guo (RU: Rutgers University)H-Index: 23
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Alcoholic fatty liver disease (AFLD) is one of the major causes of liver morbidity and mortality worldwide. We have previously shown that whole-body, but not hepatocyte-specific, deficiency of farnesoid X receptor (FXR) in mice worsens AFLD, suggesting that extrahepatic FXR deficiency is critical for AFLD development. Intestinal FXR is critical in suppressing hepatic bile acid (BA) synthesis by inducing fibroblast growth factor 15 (FGF15) in mice and FGF19 in humans. We hypothesized that intesti...
4 CitationsSource
#1Marion K. Gordon (RU: Rutgers University)H-Index: 21
#2Donald R. Gerecke (RU: Rutgers University)H-Index: 18
Last. Yoke-Chen Chang (RU: Rutgers University)H-Index: 7
view all 6 authors...
1 CitationsSource
#1Gabriella Wahler (RU: Rutgers University)H-Index: 1
#2Diane E. Heck (NYMC: New York Medical College)H-Index: 4
Last. Laurie B. Joseph (RU: Rutgers University)H-Index: 12
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Abstract Nitrogen mustard (NM) is a highly reactive bifunctional alkylating agent that induces inflammation, edema and blistering in skin. An important mechanism mediating the action of NM and related mustards is oxidative stress. In these studies a modified murine patch-test model was used to analyze DNA damage and the antioxidant/stress response following NM exposure in isolated epidermis. NM (20 μmol) was applied to glass microfiber filters affixed to a shaved dorsal region of skin of CD-1 mi...
1 CitationsSource
#1Nanxia Zhao (RU: Rutgers University)H-Index: 4
#2Xue Yang (RU: Rutgers University)H-Index: 4
Last. Prabhas V. Moghe (RU: Rutgers University)H-Index: 36
view all 11 authors...
Parkinson’s Disease is characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta, the extracellular accumulation of toxic α-synuclein (αSYN) aggregates, and neuroinflammation. Microglia, resident macrophages of the brain, are one of the critical cell types involved in neuroinflammation. Upon sensing extracellular stimuli or experiencing oxidative stress, microglia become activated, which further exacerbates neuroinflammation. In addition, as the first line of defens...
8 CitationsSource