Ele Ferrannini
National Research Council
Internal medicineEndocrinologyCardiologyCarbohydrate metabolismIntensive care medicineChemistryType 2 diabetesInsulin resistanceGlucose uptakeGlucose clamp techniqueInsulinBody mass indexHyperinsulinemiaPopulationObesityWeight lossDiabetes mellitusCXCL10MedicineBlood pressureBiology
Publications 444
#1Eleni Rebelos (UniPi: University of Pisa)H-Index: 11
#2Brenno Astiarraga (UniPi: University of Pisa)H-Index: 18
Last. Ele FerranniniH-Index: 110
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Previous work has shown that potentiation of insulin release is impaired in non-diabetic insulin resistance; we tested the hypothesis that this defect may be related to altered glucagon-like peptide-1 (GLP-1) release. On consecutive days, 82 non-diabetic individuals, classified as insulin sensitive (IS, n =41) or insulin resistant (IR, n =41) by the euglycaemic clamp, were given two sequential mixed meals with standard (75 g, LCD) or double (150 g, HCD) carbohydrate content. Plasma glucose, insu...
6 CitationsSource
#1Eleonora Grespan (National Research Council)H-Index: 4
#2Toni Giorgino (National Research Council)H-Index: 20
Last. Andrea Mari (National Research Council)H-Index: 67
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In vivo studies have investigated the role of β-cell dysfunction in type 2 diabetes (T2D), whereas in vitro research on islets has elucidated key mechanisms that control the insulin secretion rate. However, the relevance of the cellular mechanisms identified in vitro (i.e., the triggering and amplifying pathways) has not been established in vivo. Furthermore, the mechanisms underpinning β-cell dysfunction in T2D remain undetermined. We propose a unifying explanation of several characteristic fea...
14 CitationsSource
#1Adil Mardinoglu (Chalmers University of Technology)H-Index: 39
#2Silvia Gogg (Sahlgrenska University Hospital)H-Index: 11
Last. Ulf Smith (Sahlgrenska University Hospital)H-Index: 108
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Branched-chain amino acids (BCAAs) metabolite, 3-Hydroxyisobutyric acid (3-HIB) has been identified as a secreted mediator of endothelial cell fatty acid transport and insulin resistance (IR) using animal models. To identify if 3-HIB is a marker of human IR and future risk of developing Type 2 diabetes (T2D), we measured plasma levels of 3-HIB and associated metabolites in around 10,000 extensively phenotyped individuals. The levels of 3-HIB were increased in obesity but not robustly associated ...
17 CitationsSource
#1Silvio E. Inzucchi (Yale University)H-Index: 97
#2Bernard Zinman (Lunenfeld-Tanenbaum Research Institute)H-Index: 42
Last. John M. Lachin (GW: George Washington University)H-Index: 99
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OBJECTIVE In the BI 10773 (Empagliflozin) Cardiovascular Outcome Event Trial in Type 2 Diabetes Mellitus Patients (EMPA-REG OUTCOME) trial involving 7,020 patients with type 2 diabetes and established cardiovascular (CV) disease, empagliflozin given in addition to standard of care reduced the risk of CV death by 38% versus placebo (hazard ratio [HR] 0.62 [95% CI 0.49, 0.77]). This exploratory mediation analysis assesses the extent to which treatment group differences in covariates during the tri...
272 CitationsSource
#1Ele FerranniniH-Index: 110
#2Anna Solini (UniPi: University of Pisa)H-Index: 49
Two phase III trials using the selective SGLT2 inhibitor dapagliflozin or the dual SGLT2/SGLT1 inhibitor sotagliflozin in patients with type 1 diabetes mellitus show similar clinical benefit (reduction of HbA1c, body weight, blood pressure and insulin dose). The risk of hypoglycaemia and diabetic ketoacidosis with these inhibitors can be managed by careful adjustment of insulin therapy.
4 CitationsSource
#1Bernard Zinman (Lunenfeld-Tanenbaum Research Institute)H-Index: 42
#2Jay S. Skyler (UM: University of Miami)H-Index: 76
Last. Ele Ferrannini (UniPi: University of Pisa)H-Index: 14
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As has been well established, the Diabetes Care journal’s most visible signature event is the Diabetes Care Symposium held each year during the American Diabetes Association’s Scientific Sessions. Held this past year on 10 June 2017 in San Diego, California, at the 77th Scientific Sessions, this event has become one of the most attended sessions during the Scientific Sessions. Each year, in order to continue to have the symposium generate interest, we revise the format and content of this event....
7 CitationsSource
#1Edoardo Mannucci (UniFI: University of Florence)H-Index: 98
#2Ele FerranniniH-Index: 110
Last. Ele FerranniniH-Index: 14
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6 CitationsSource
#1Anna Solini (UniPi: University of Pisa)H-Index: 49
#2Chiara Rossi (UniPi: University of Pisa)H-Index: 15
Last. Ele FerranniniH-Index: 14
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Aim To quantify the expression of sodium-glucose co-transporter (SGLT)2 and SGLT1, their cognate basolateral transporters, GLUT2 and GLUT1, and the transcriptional regulator of SGLTs in renal tissue obtained from people with T2DM and a group of well-matched people without diabetes. Methods We measured SGLT2 and SGLT1 expression in unaffected renal tissue from 19 people with T2DM and 20 people without diabetes, matched for age and estimated glomerular filtration rate (controls), undergoing unilat...
37 CitationsSource
#1Kirstine J. Belongie (Janssen Pharmaceutica)H-Index: 1
#2Ele FerranniniH-Index: 110
Last. John R. Petrie (Glas.: University of Glasgow)H-Index: 58
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A decline in β-cell function is a prerequisite for the development of type 2 diabetes, yet the level of β-cell function in individuals at risk of the condition is rarely measured. This is due, in part, to the fact that current methods for assessing β-cell function are inaccurate, prone to error, labor-intensive, or affected by glucose-lowering therapy. The aim of the current study was to identify novel circulating biomarkers to monitor β-cell function and to identify individuals at high risk of ...
20 CitationsSource
#1Stefania Camastra (UniPi: University of Pisa)H-Index: 37
#2Alessandra VitaliH-Index: 7
Last. Ele FerranniniH-Index: 110
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Obesity is characterized by insulin-resistance (IR), enhanced lipolysis, and ectopic, inflamed fat. We related the histology of subcutaneous (SAT), visceral fat (VAT), and skeletal muscle to the metabolic abnormalities, and tested their mutual changes after bariatric surgery in type 2 diabetic (T2D) and weight-matched non-diabetic (ND) patients. We measured IR (insulin clamp), lipolysis (2H5-glycerol infusion), s-cell glucose-sensitivity (s-GS, mathematical modeling), and VAT, SAT, and rectus ab...
26 CitationsSource