Ele Ferrannini
National Research Council
Internal medicineEndocrinologyCardiologyCarbohydrate metabolismIntensive care medicineChemistryType 2 diabetesInsulin resistanceGlucose uptakeGlucose clamp techniqueInsulinBody mass indexHyperinsulinemiaPopulationObesityWeight lossDiabetes mellitusCXCL10MedicineBlood pressureBiology
448Publications
110H-index
46.9kCitations
Publications 450
Newest
#1Eleni RebelosH-Index: 11
#2Jussi HirvonenH-Index: 42
Last. Pirjo NuutilaH-Index: 87
view all 11 authors...
Source
#1Luca Antonioli (UniPi: University of Pisa)H-Index: 26
#2Diego Moriconi (UniPi: University of Pisa)H-Index: 6
Last. Monica Nannipieri (UniPi: University of Pisa)H-Index: 30
view all 11 authors...
OBJECTIVE: Interleukin (IL)-1beta is involved in obesity-associated inflammation and in the pathogenesis of type 2 diabetes (T2D) mellitus. Our aim was to correlate serum IL-1beta and caspase-1 levels with weight loss, glucose metabolism, and insulin resistance (IR) after bariatric surgery. METHODS: A total of 32 patients with morbid obesity and T2D (Ob-T2D) and 29 patients with morbid obesity and normal glucose tolerance (Ob-NGT), treated by Roux-en-Y gastric bypass, were studied before and 1 y...
2 CitationsSource
#1Giulia Ferrannini (KI: Karolinska Institutet)H-Index: 5
#2Maria Laura Manca (UniPi: University of Pisa)H-Index: 23
Last. Ele FerranniniH-Index: 110
view all 11 authors...
OBJECTIVE Coronary artery disease (CAD) is a major challenge in patients with type 2 diabetes (T2D). Coronary computed tomography angiography (CCTA) provides a detailed anatomic map of the coronary circulation. Proteomics are increasingly used to improve diagnostic and therapeutic algorithms. We hypothesized that the protein panel is differentially associated with T2D and CAD. RESEARCH DESIGN AND METHODS In CAPIRE (Coronary Atherosclerosis in Outlier Subjects: Protective and Novel Individual Ris...
5 CitationsSource
#1Niki KatsikiH-Index: 45
#1Niki KatsikiH-Index: 1
Last. Mohsen MazidiH-Index: 6
view all 4 authors...
Source
#1Ele FerranniniH-Index: 110
#2Simona Baldi (UniPi: University of Pisa)H-Index: 32
Last. Ralph A. DeFronzo (University of Texas Health Science Center at San Antonio)H-Index: 182
view all 8 authors...
AIM: To determine the effects of individual and combined therapies on plasma insulin, glucagon, β-hydroxybutyrate (β-OH) and associated metabolites. MATERIALS AND METHODS: In DURATION-8, the combination of once-weekly exenatide (EQW) + 10 mg dapagliflozin (Dapa) in patients with type 2 diabetes poorly controlled with metformin-reduced HbA1c levels and body weight (at weeks 28 and 52) was compared with EQW + placebo (Plb) or Dapa + Plb. The study included 678 patients randomized 1:1:1 to EQW + Da...
3 CitationsSource
#1Amalia GastaldelliH-Index: 85
#2Enrico RepettoH-Index: 3
Last. Ele FerranniniH-Index: 110
view all 7 authors...
Source
#1Natasha Ng (University of Oxford)
#2Sara M. Willems (University of Cambridge)H-Index: 31
Last. Inês Barroso (Wellcome Trust Sanger Institute)H-Index: 109
view all 262 authors...
Metabolic dysregulation in multiple tissues alters glucose homeostasis and influences risk for type 2 diabetes (T2D). To identify pathways and tissues influencing T2D-relevant glycemic traits (fasting glucose [FG], fasting insulin [FI], two-hour glucose [2hGlu] and glycated hemoglobin [HbA1c]), we investigated associations of exome-array variants in up to 144,060 individuals without diabetes of multiple ancestries. Single-variant analyses identified novel associations at 21 coding variants in 18...
3 CitationsSource
#1Natasha H. J. Ng (University of Oxford)H-Index: 1
#2Sara M. Willems (University of Cambridge)H-Index: 31
Last. Inês Barroso (University of Cambridge)H-Index: 109
view all 262 authors...
Summary Metabolic dysregulation in multiple tissues alters glucose homeostasis and influences risk for type 2 diabetes (T2D). To identify pathways and tissues influencing T2D-relevant glycemic traits (fasting glucose [FG], fasting insulin [FI], two-hour glucose [2hGlu] and glycated hemoglobin [HbA1c]), we investigated associations of exome-array variants in up to 144,060 individuals without diabetes of multiple ancestries. Single-variant analyses identified novel associations at 21 coding varian...
6 CitationsSource
#1Eleni Rebelos (UTU: University of Turku)H-Index: 11
#2Prince Dadson (UTU: University of Turku)H-Index: 5
Last. Pirjo Nuutila (UTU: University of Turku)H-Index: 87
view all 8 authors...
Human studies of renal hemodynamics and metabolism in obesity are insufficient. We hypothesized that renal perfusion and renal FFA uptake are higher in morbidly obese as compared to lean subjects a...
9 CitationsSource
#1Ele FerranniniH-Index: 110
#2Simona BaldiH-Index: 32
Last. Ralph A. DeFronzoH-Index: 182
view all 8 authors...
Source