Ele Ferrannini
National Research Council
Internal medicineEndocrinologyCardiologyCarbohydrate metabolismIntensive care medicineChemistryType 2 diabetesInsulin resistanceGlucose uptakeGlucose clamp techniqueInsulinBody mass indexHyperinsulinemiaPopulationObesityWeight lossDiabetes mellitusCXCL10MedicineBlood pressureBiology
Publications 444
#1Niki Katsiki (A.U.Th.: Aristotle University of Thessaloniki)H-Index: 45
#2Ele FerranniniH-Index: 110
Last. Christos S. Mantzoros (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 139
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3 CitationsSource
#1Eleni Rebelos (UniPi: University of Pisa)H-Index: 11
#2Diego Moriconi (UniPi: University of Pisa)H-Index: 6
Last. Monica Nannipieri (UniPi: University of Pisa)H-Index: 30
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Postprandial hypoglycemia (PPHG) is a well-known complication after bariatric surgery (BS). However, it is not known whether PPHG affects weight loss after BS. To assess the impact of PPHG on weight loss after BS in subjects without and with type 2 diabetes mellitus (T2D). Data from 338 subjects who had undergone gastric bypass (RYGB) or sleeve gastrectomy (LSG) and were followed up for at least 2 years were analyzed. At each follow-up visit, the patient’s anthropometric and biochemical characte...
3 CitationsSource
#1Amalia GastaldelliH-Index: 85
#2Enrico Repetto (AstraZeneca)H-Index: 3
Last. Ele FerranniniH-Index: 14
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AIM: To assess the efficacy of exenatide (EXE) once weekly + dapagliflozin once daily (DAPA) versus each drug alone in reducing biomarkers of fatty liver/steatosis and fibrosis in a post hoc analysis of DURATION-8, a 104-week study in 695 patients with type 2 diabetes uncontrolled by metformin monotherapy. MATERIALS AND METHODS: We evaluated the impact of the study treatments on non-invasive markers of hepatic steatosis (fatty liver index [FLI] and non-alcoholic fatty liver disease [NAFLD] liver...
15 CitationsSource
2 CitationsSource
#1Eleni Rebelos (Åbo Akademi University)H-Index: 11
#2Jussi Hirvonen (TYKS: Turku University Hospital)H-Index: 42
Last. Pirjo Nuutila (UTU: University of Turku)H-Index: 87
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AIM: To investigate whether there are differences in brain fatty acid uptake (BFAU) between morbidly obese and lean subjects, and the effect of weight loss following bariatric surgery. MATERIALS AND METHODS: We measured BFAU with 14(R, S)-[(18) F]fluoro-6-thia-heptadecanoic acid and positron emission tomography in 24 morbidly obese and 14 lean women. Obese subjects were restudied 6 months after bariatric surgery. We also assessed whether there was hypothalamic neuroinflammation in the obese subj...
5 CitationsSource
#1Luca Antonioli (UniPi: University of Pisa)H-Index: 26
#2Diego Moriconi (UniPi: University of Pisa)H-Index: 6
Last. Monica Nannipieri (UniPi: University of Pisa)H-Index: 30
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OBJECTIVE: Interleukin (IL)-1beta is involved in obesity-associated inflammation and in the pathogenesis of type 2 diabetes (T2D) mellitus. Our aim was to correlate serum IL-1beta and caspase-1 levels with weight loss, glucose metabolism, and insulin resistance (IR) after bariatric surgery. METHODS: A total of 32 patients with morbid obesity and T2D (Ob-T2D) and 29 patients with morbid obesity and normal glucose tolerance (Ob-NGT), treated by Roux-en-Y gastric bypass, were studied before and 1 y...
2 CitationsSource
#1Eleni RebelosH-Index: 11
#2Jussi HirvonenH-Index: 42
Last. Pirjo NuutilaH-Index: 87
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#1Giulia Ferrannini (KI: Karolinska Institutet)H-Index: 5
#2Maria Laura Manca (UniPi: University of Pisa)H-Index: 23
Last. Ele FerranniniH-Index: 110
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OBJECTIVE Coronary artery disease (CAD) is a major challenge in patients with type 2 diabetes (T2D). Coronary computed tomography angiography (CCTA) provides a detailed anatomic map of the coronary circulation. Proteomics are increasingly used to improve diagnostic and therapeutic algorithms. We hypothesized that the protein panel is differentially associated with T2D and CAD. RESEARCH DESIGN AND METHODS In CAPIRE (Coronary Atherosclerosis in Outlier Subjects: Protective and Novel Individual Ris...
4 CitationsSource
#1Niki KatsikiH-Index: 45
#1Niki KatsikiH-Index: 1
Last. Mohsen MazidiH-Index: 6
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#1Ele FerranniniH-Index: 110
#2Simona Baldi (UniPi: University of Pisa)H-Index: 32
Last. Ralph A. DeFronzo (University of Texas Health Science Center at San Antonio)H-Index: 182
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AIM: To determine the effects of individual and combined therapies on plasma insulin, glucagon, β-hydroxybutyrate (β-OH) and associated metabolites. MATERIALS AND METHODS: In DURATION-8, the combination of once-weekly exenatide (EQW) + 10 mg dapagliflozin (Dapa) in patients with type 2 diabetes poorly controlled with metformin-reduced HbA1c levels and body weight (at weeks 28 and 52) was compared with EQW + placebo (Plb) or Dapa + Plb. The study included 678 patients randomized 1:1:1 to EQW + Da...
2 CitationsSource