Debbie M. Cheng
Boston University
PsychiatryInternal medicinePublic healthCross-sectional studyDemographyLogistic regressionOdds ratioRandomized controlled trialCohort studyImmunologyDrugAcquired immunodeficiency syndrome (AIDS)PopulationHuman immunodeficiency virus (HIV)Substance abuseConfidence intervalAddictionMedicineCohortEnvironmental health
254Publications
44H-index
5,374Citations
Publications 245
Newest
#1Frantz Pierre (BU: Boston University)
#2Leah S. Forman (BU: Boston University)H-Index: 7
Last. Kaku So-Armah (BU: Boston University)H-Index: 12
view all 12 authors...
Aims Alcohol is hypothesized to have effects on the kynurenine pathway of tryptophan catabolism, a potential mechanism for alcohol-induced depression and aggression. A biomarker of this pathway, the plasma kynurenine to tryptophan ratio (K/T ratio), has been associated with HIV progression, mortality and depression. Our aim was to assess whether hazardous alcohol consumption is associated higher K/T ratio among people with HIV. Methods Participants were a subset of the Uganda Alcohol Research Co...
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#1Sara Lodi (BU: Boston University)H-Index: 16
#2Nneka Emenyonu (UCSF: University of California, San Francisco)H-Index: 26
Last. Gabriel Chamie (UCSF: University of California, San Francisco)H-Index: 23
view all 13 authors...
BACKGROUND The risk of tuberculosis (TB) is high among people with HIV (PWH). Heavy alcohol drinking independently increases TB risk and approximately 25% of PWH globally engage in heavy drinking. While isoniazid (INH) preventive therapy decreases TB incidence and mortality among PWH, heavy drinking during INH is associated with liver toxicity and poor adherence. Interventions are, therefore, urgently needed to decrease alcohol use and improve adherence to INH in this population in settings with...
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#1Daniel Fuster (Autonomous University of Barcelona)H-Index: 15
#2Kaku So-Armah (BU: Boston University)H-Index: 12
Last. Jeffrey H. Samet (BU: Boston University)H-Index: 75
view all 9 authors...
AIMS To analyze the association between any past month cannabis use and advanced liver fibrosis. BACKGROUND Cannabinoid receptors play a role in acute and chronic liver injury, but human studies addressing the impact of cannabis use on liver fibrosis have shown mixed results. OBJECTIVES To explore and estimate the association between past month cannabis use and advanced liver fibrosis (ALF) in a cohort of Russian HIV-positive individuals with heavy alcohol use and high prevalence of hepatitis C ...
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#1Daniel Fuster (Autonomous University of Barcelona)H-Index: 15
#2David Nunes (BU: Boston University)H-Index: 28
Last. Jeffrey H. Samet (BU: Boston University)H-Index: 75
view all 5 authors...
BACKGROUND The impact of Hepatitis C virus (HCV) RNA levels on the evolution of chronic HCV infection-related liver damage is controversial. Heavy alcohol use is believed to have a deleterious impact on the course of HCV disease, but current knowledge about the possible effect of alcohol use on HCV RNA levels in HIV/HCV coinfected patients is limited. METHODS We examined 107 HIV/HCV-infected individuals with current or past unhealthy alcohol use to assess the association between alcohol consumpt...
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#1Sara Lodi (BU: Boston University)H-Index: 16
#2Matthew S. Freiberg (VUMC: Vanderbilt University Medical Center)H-Index: 43
Last. Debbie M. Cheng (BU: Boston University)H-Index: 44
view all 9 authors...
BACKGROUND The Zinc for INflammation and Chronic disease in HIV (ZINC) trial randomized person who live with HIV (PLWH) who engage in heavy drinking to either daily zinc supplementation or placebo. The primary outcome was change in the Veterans Aging Cohort Study (VACS) index, a predictor of mortality, between baseline and 18 months. Because adherence and follow-up were suboptimal, the intention-to-treat analysis, which was not statistically significant, may have underestimated the effect of the...
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#1Belle V. Ngo (UW: University of Washington)
#2Jane M. Liebschutz (University of Pittsburgh)H-Index: 29
Last. Judith I. Tsui (UW: University of Washington)H-Index: 17
view all 11 authors...
BACKGROUND Alcohol use is common among persons living with HIV (PLWH), who often experience chronic pain, yet its impact on pain and opioid misuse is not fully characterized. METHODS We assessed associations between hazardous alcohol use and pain interference, defined as the self-reported impact of pain on daily living, pain severity, and risk for opioid misuse among PLWH who were on long-term opioid therapy (LTOT). A cohort was recruited as part of the "Targeting Effective Analgesia in Clinics ...
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#1Maria A. Corcorran (UW: University of Washington)H-Index: 6
#2Natasha Ludwig-Baron (UW: University of Washington)
Last. Judith I. Tsui (UW: University of Washington)H-Index: 17
view all 12 authors...
This study describes the self-reported prevalence of hepatitis C virus (HCV) coinfection and the HCV care continuum among persons enrolled in the St PETER HIV Study, a randomized controlled trial of medications for smoking and alcohol cessation in HIV-positive heavy drinkers and smokers in St. Petersburg, Russia. Baseline health questionnaire data were used to calculate proportions and 95% confidence intervals for self-reported steps along the HCV continuum of care. The cohort included 399 HIV-p...
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#1Sally Bendiks (BMC: Boston Medical Center)H-Index: 2
#2Debbie M. Cheng (BU: Boston University)H-Index: 44
Last. Judith I Tsui (Harborview Medical Center)H-Index: 4
view all 10 authors...
Pain is common and associated with substance use among persons with HIV (PWH), yet limited management strategies exist. We assessed the feasibility, tolerability, and safety of low-dose naltrexone ...
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#1Kathryn Chavez (BU: Boston University)H-Index: 4
#2Tibor P. Palfai (BU: Boston University)H-Index: 38
Last. Jeffrey H. Samet (BU: Boston University)H-Index: 75
view all 8 authors...
BACKGROUND AND OBJECTIVES Previous findings on the association between hazardous drinking and HIV-risk behavior have been equivocal, varying by population and individual difference factors. This study examined associations between hazardous drinking, impulsivity, and HIV-risk behaviors among HIV-positive Russian patients with a history of injection drug use (IDU), not on antiretroviral therapy. METHODS Negative binomial regression analyses of data from a randomized controlled trial were performe...
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#1Julius S. Ngwa (BU: Boston University)H-Index: 26
#2Howard J. Cabral (BU: Boston University)H-Index: 2
Last. L. Adrienne Cupples (BU: Boston University)H-Index: 156
view all 6 authors...
BACKGROUND Statistical methods for modeling longitudinal and time-to-event data has received much attention in medical research and is becoming increasingly useful. In clinical studies, such as cancer and AIDS, longitudinal biomarkers are used to monitor disease progression and to predict survival. These longitudinal measures are often missing at failure times and may be prone to measurement errors. More importantly, time-dependent survival models that include the raw longitudinal measurements m...
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