Sara Pusceddu
University of Milan
CancerInternal medicineSurgeryPathologyOncologyAdverse effectSomatostatinChemotherapyNeuroendocrine tumorsDiseaseEverolimusMetforminProgression-free survivalOctreotideIn patientWell differentiatedCancer researchMedicineGastroenterologyPharmacology
Publications 137
#1Sara PuscedduH-Index: 18
#2Antonio Facciorusso (University of Foggia)H-Index: 19
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Although combination therapy is not recommended in patients with gastro-entero-pancreatic (GEP) neuroendocrine tumors (NETs), this strategy is widely used in clinical practice. This network meta-analysis of randomized trials evaluates targeted therapies and somatostatin analogues in GEP advanced NETs, either alone or in combination, comparing the efficacy of different single or combined treatment strategies in terms of progression-free survival (PFS). Interventions were grouped as analogues, eve...
#1Ketevani Kankava (Tbilisi State Medical University)H-Index: 3
#2Patrick Maisonneuve (IEO: European Institute of Oncology)H-Index: 134
Last. Stefano Di DomenicoH-Index: 9
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Updates in classification of gastro-entero-pancreatic neuroendocrine neoplasms better reflect the biological characteristics of these tumours. In the present study, we analysed the characteristics of neuroendocrine tumours that could aid in a more precise stratification of risk groups. In addition, we have highlighted the importance of grade (re)assessment based on investigation of secondary tumour lesions. Two hundred and sixty-four cases of neuroendocrine tumours of gastro-entero-pancreatic or...
#1Martina TorchioH-Index: 8
#2Laura CattaneoH-Index: 12
Last. Giulia Bertino (UNIPV: University of Pavia)H-Index: 19
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This case report shows, for the first time, a patient experiencing a complete response after one dose of avelumab following extensive disease progression with prior electrochemotherapy (ECT) treatment. We suggest that ECT may help to establish a tumor microenvironment favorable to immunotherapy. Merkel cell carcinoma (MCC) is a highly aggressive skin cancer with seldom durable chemotherapy responses. ECT has recently emerged as a potential treatment option for several malignancies, including MCC...
INTRODUCTION: The organization of the healthcare system has significantly changed after the recent COVID-19 outbreak, with a negative impact on the management of oncological patients. The present survey reports data collected by the Italian Association for Neuroendocrine Tumors on the management of patients with neuroendocrine neoplasia (NEN) during the pandemic dissemination. METHODS: A survey with 57 questions was sent to NEN-dedicated Italian centers regarding the management of patients in th...
7 CitationsSource
#1Natalie PrinziH-Index: 12
#2Roberta Elisa Rossi (University of Milan)H-Index: 26
Last. Sara PuscedduH-Index: 18
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Neuroendocrine neoplasms of the lung represent about 20% to 30% of all neuroendocrine tumors. On the basis of clinical and pathologic characteristics, 2 different categories of tumors may be defined: poorly differentiated neuroendocrine neoplasms, characterized by a high rate of recurrences and poor prognosis, and well-differentiated neuroendocrine neoplasms (typical carcinoids and atypical carcinoids), which generally display an indolent course. Lung carcinoids represent only 1% to 5% of all lu...
#1Massimo MilioneH-Index: 31
#2Patrick MaisonneuveH-Index: 134
Last. Carlo CapellaH-Index: 89
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BACKGROUND: Little information is available concerning prognostic factors of bronchopulmonary large cell neuroendocrine carcinomas (BP-LCNECs) and even less is known about combined LCNECs (Co-LCNECs). We investigated whether an integrated morphological, immunohistochemical and molecular approach could be used for their prognostic evaluation. METHODS: Morphological (including combined features), proliferative (mitotic count/Ki-67 index), immunohistochemical (napsin A, p-40, TTF-1, CD44, OTP, SSTR...
5 CitationsSource
#1Giovanni CentonzeH-Index: 11
#2Vincenzo LaganoH-Index: 1
Last. Massimo MilioneH-Index: 31
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High-grade Gastroenteropancreatic Neuroendocrine neoplasms (H-NENs) comprehend well-differentiated tumors (NET G3) and poorly differentiated carcinomas (NEC) with proliferative activity indexes as mitotic count (MC) >20 mitoses/10 HPF and Ki-67 >20%. At present, no specific therapy for H-NENs exists and the several evidences of microenvironment involvement in their pathogenesis pave the way for tailored therapies. Forty-five consecutive cases, with available information about T-cell, immune, and...
1 CitationsSource
#1Ketevani KankavaH-Index: 3
#2Patrick MaisonneuveH-Index: 134
view all 15 authors...
#1Sara Massironi (University of Milano-Bicocca)H-Index: 27
#2Davide Campana (UNIBO: University of Bologna)H-Index: 28
Last. Massimo FalconiH-Index: 105
view all 24 authors...
Abstract Background Patients with sporadic neuroendocrine neoplasms may exhibit a higher risk of a second primary tumor than the general population. Aim This study aimed to analyze the occurrence of second primary malignancies. Methods A retrospective cohort of 2757 patients with sporadic lung and gastro-entero-pancreatic neuroendocrine neoplasms, managed at eight Italian tertiary referral Centers, was included. Results Between 2000 and 2019, a second primary malignancy was observed in 271 (9.8%...