Cindy Qiu
University College London
AnatomyLuciferaseSecondary palate developmentTransforming growth factorInternal medicineDownregulation and upregulationEndocrinologyPathologyEmbryonic stem cellMolecular biologyGap junctionReceptorPlatelet-derived growth factor receptorCell typeDentistryIn vivoGrowth factorGranulation tissueNeutrophil elastaseMesenchymeInflammationDermisInfiltration (medical)Transforming growth factor betaPlasminogen activatorSecondary palateConnexinWound healingCystLesionPlatelet-derived growth factorSubmucous cleft palateCongenital diseaseBurn injuryDouble rowRecien nacidoCentral nervous systemEpitheliumGene isoformMedicineIntracellularBiologyEpidermis (botany)Cell biology
6Publications
6H-index
614Citations
Publications 6
Newest
#1Petula Coutinho (UCL: University College London)H-Index: 3
#2Cindy Qiu (UCL: University College London)H-Index: 6
Last. David L. Becker (UCL: University College London)H-Index: 51
view all 7 authors...
Summary Extension of a burn wound over the first 24h following injury is recognised clinically, and leads to diagnostic and therapeutic dilemmas. In the central nervous system, a similar spread of damage, beyond the initial injury, can occur via the spread of death signals from injured cells to their healthy neighbours via Connexin43 (Cx43) gap junction channels. In the skin, Cx43 is expressed in the basal epidermis and in fibroblasts and dermal appendages. We have used Cx43 specific antisense o...
Source
#1Cindy Qiu (UCL: University College London)H-Index: 6
#2Petula Coutinho (UCL: University College London)H-Index: 3
Last. David L. Becker (UCL: University College London)H-Index: 51
view all 8 authors...
The repair of tissue damage is a key survival process in all organisms and involves the coordinated activation of several cell types. Cell-cell communication is clearly fundamental to this process, and a great deal is known about extracellular communication within the wound site via cytokines [1, 2]. Here we show that direct cell-cell communication through connexin 43 (Cx43) gap junction channels [3, 4] also plays a major role in the wound healing process. In two different wound healing models, ...
Source
#1Petula Coutinho (UCL: University College London)H-Index: 3
#2Cindy Qiu (UCL: University College London)H-Index: 6
Last. David L. Becker (UCL: University College London)H-Index: 51
view all 5 authors...
Wound healing is a complex process requiring communication for the precise co-ordination of different cell types. The role of extracellular communication through growth factors in the wound healing process has been extensively documented, but the role of direct intercellular communication via gap junctions has scarcely been investigated. We have examined the dynamics of gap junction protein (Connexins 26, 30, 31.1 and 43) expression in the murine epidermis and dermis during wound healing, and we...
Source
#1Bruce M. RichardH-Index: 1
#2Cindy Qiu (University of Manchester)H-Index: 6
Last. Mark W. J. Ferguson (University of Manchester)H-Index: 77
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Summary Palatal cysts (Epstein pearls) are occasionally noticed as white papules on the palatal mucosa of a neonate whilst having its 6-week postnatal check. We describe five cleft patients and the distribution characteristics of their palatal cysts, including the previously unrecorded observation of a submucons cleft palate with a double row of palatal cysts, one row on each side of the zona pellucida. The role of spatial morphology of palatal cysts in interpreting cleft pathogenesis is discuss...
Source
#1Liju Yang (University of Manchester)H-Index: 1
#2Cindy Qiu (University of Manchester)H-Index: 6
Last. Georg Brunner (University of Manchester)H-Index: 3
view all 5 authors...
Transforming growth factor (TGF)-β regulates wound repair and scarring in an isoform-specific fashion. TGF-β is produced in a latent form, and its activation is a critical regulatory step controlling the bioactivity of this growth factor. To date, it has been impossible to determine latent TGF-β activation in vivo due to a lack of quantitative assays. We describe here a semiquantitative modification of the plasminogen activator inhibitor-1/luciferase bioassay (PAI/L assay) for TGF-β, which we us...
Source
#1Cindy Qiu (University of Manchester)H-Index: 6
#2M. W. J. FergusonH-Index: 1
Abstract The distribution of the 2 homodimer isoforms of platelet-derived growth factor (PDGF)-AA and -BB, and their receptors (PDGF alpha-receptor and PDGF beta-receptor) were mapped immunocytochemically during the development of the embryonic mouse secondary palate, from embryonic day (E) 12 to E15. The staining patterns of PDGF-AA/alpha-receptor and PDGF-BB/beta-receptor are different. Generally, the former is present and the latter is sparse/absent during the period of palate development. Th...
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