Shaohai Qi
Sun Yat-sen University
Internal medicineEndocrinologyBiomedical engineeringSurgeryPathologyRegeneration (biology)ChemistryMesenchymal stem cellIn vivoWound healingFibroblastAngiogenesisStem cellTransplantationCancer researchCell growthSignal transductionMedicineBiologyCell biology
45Publications
13H-index
647Citations
Publications 45
Newest
#1Ruizhao Cai (SYSU: Sun Yat-sen University)H-Index: 1
#2Miao Zhen (SYSU: Sun Yat-sen University)
Last. Shaohai Qi (SYSU: Sun Yat-sen University)H-Index: 13
view all 10 authors...
Vibrio vulnificus (V. vulnificus) infection is rare but potentially fatal. This study explored the new atypical manifestations and prognostic factors of V. vulnificus-infected patients throughout hospitalization. we retrospectively reviewed 33 patients diagnosed as having V. vulnificus infection in Guangdong Province, China between 2010 and 2020. Medical records were analyzed. Multiple logistic regression and receiver operating characteristic (ROC) curve analyses were performed. New atypical man...
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#1Ruizhao Cai (SYSU: Sun Yat-sen University)H-Index: 1
#2Ning Liu (SYSU: Sun Yat-sen University)H-Index: 1
Last. Shaohai Qi (SYSU: Sun Yat-sen University)H-Index: 13
view all 10 authors...
Vibrio (V.) vulnificus infection is a rare disease whose death rates exceed 50% despite aggressive antibiotic treatment and surgical debridement. The aim of this study was to assess the ability of specific anti-V. vulnificus immunoglobulins Y (IgYs) for preventing and treating V. vulnificus infections. IgYs were produced by immunizing egg laying hens with inactivated whole cell bacteria. Peritoneal cytokines, blood’s bacterial load, and survival curves were obtained from both prophylactic and th...
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#1Shuai Yang (SYSU: Sun Yat-sen University)H-Index: 2
#2Jingling Zhao (SYSU: Sun Yat-sen University)H-Index: 8
Last. Shaohai Qi (SYSU: Sun Yat-sen University)H-Index: 13
view all 11 authors...
The reduced hydration environment induced by disruption of epithelial barrier function after injury results in excessive scarring, but the underlying mechanisms are poorly understood. We demonstrated that exposing keratinocytes to a reduced hydration environment causes epithelial-to-mesenchymal transition (EMT) and induces caveolin-1-dependent downregulation of E-cadherin. Reduced caveolin-1 expression and increased Snail expression are associated with low expression levels of E-cadherin. Caveol...
#1Jingling Zhao (SYSU: Sun Yat-sen University)H-Index: 8
#2Shuai Yang (SYSU: Sun Yat-sen University)H-Index: 2
Last. Shaohai Qi (SYSU: Sun Yat-sen University)H-Index: 13
view all 9 authors...
The progression of diabetic complications does not halt despite the termination of hyperglycemia, suggesting a metabolic memory phenomenon. However, whether metabolic memory exists in and affects the healing of diabetic wounds, as well as the underlying molecular mechanisms, remain unclear. In this study, we found that wound healing was delayed, and angiogenesis was decreased in mice with diabetes despite the normalization of glycemic control. Thus, we hypothesized that transient hyperglycemic s...
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#1Junyou Zhu (SYSU: Sun Yat-sen University)H-Index: 1
#2Jin Deng (Guangzhou Medical University)H-Index: 2
Last. Shaohai Qi (SYSU: Sun Yat-sen University)H-Index: 13
view all 10 authors...
Background Human skin cutaneous melanoma is the most common and dangerous skin tumour, but its pathogenesis is still unclear. Although some progress has been made in genetic research, no molecular indicators related to the treatment and prognosis of melanoma have been found. In various diseases, dysregulation of lncRNA is common, but its role has not been fully elucidated. In recent years, the birth of the "competitive endogenous RNA" theory has promoted our understanding of lncRNAs. Methods To ...
2 CitationsSource
#1Shaohai Qi (SYSU: Sun Yat-sen University)H-Index: 13
#2Jingling Zhao (SYSU: Sun Yat-sen University)H-Index: 8
Last. Bin Shu (SYSU: Sun Yat-sen University)H-Index: 16
view all 9 authors...
The progression of diabetic complications does not halt despite termination of hyperglycemia, suggesting a "metabolic memory" phenomenon. However, whether metabolic memory exists in and affects the healing of diabetic wounds, as well as the underlying molecular mechanisms, remain unclear. In this study, we found that wound healing was delayed and angiogenesis was decreased in diabetic mice, despite normalization of glycemic control. Thus, we hypothesized that transient hyperglycemic spikes may b...
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#1Mingzhou Yuan (SYSU: Sun Yat-sen University)H-Index: 1
#2Meifang Yin (SYSU: Sun Yat-sen University)
Last. Jun Wu (SYSU: Sun Yat-sen University)H-Index: 53
view all 13 authors...
In recent years, hydrosurgery is a technology that has been applied more and more in debridement procedures. However, the selectivity of hydrosurgery to cutaneous necrotic tissues has not been proved. This study was designed to investigate the possible tissue selectivity of hydrosurgery in the debridement in burn wounds. Deep partial-thickness burns were produced on the back of porcine, and 48 hours later, both burn wounds and normal skin were debrided using the hydrosurgery system. Then tissue ...
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#1Junyou Zhu (SYSU: Sun Yat-sen University)H-Index: 1
#2Bin Shu (SYSU: Sun Yat-sen University)H-Index: 16
Last. Zhicheng Hu (SYSU: Sun Yat-sen University)H-Index: 10
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Abstract Background Scald burns in the neonate are rare in literature, especially major full-thickness injuries in newborns. However, burns are the third most common cause of accidental death among children in the United States. We hope that this report can provide us a new insight for guiding the timing of surgical treatment and the choice of the surgical scheme in severe burn neonates. Case presentation: In this case report, we demonstrate a case of a three-hour-old neonate, who suffered from ...
1 CitationsSource
#1Lijun Zhang (SYSU: Sun Yat-sen University)H-Index: 3
#2Hanxiao Yin (SYSU: Sun Yat-sen University)H-Index: 1
Last. Jun Wu (SYSU: Sun Yat-sen University)H-Index: 53
view all 11 authors...
The purpose of this systematic review and meta-analysis is to assess the clinical effectiveness and safety of the medical hydrogel dressings used in skin wounds and therefore to weight the evidence for their clinical application. PubMed/Medline (1980–2019), Cochrane Library (1980–2019), ClinicalTrials.gov, Cochrane CENTRAL, Chinese Journal Full-text Database (CNKI, 1994–2019), and China Biomedy Medicine disc (CBM, 1978–2019), Chinese Scientific Journal Database (VIP, 1989–2019), and Wanfang Data...
12 CitationsSource
#1Jingling Zhao (NU: Northwestern University)H-Index: 3
#2Ping Xie (NU: Northwestern University)H-Index: 21
Last. Seok Jong Hong (NU: Northwestern University)H-Index: 27
view all 7 authors...
: Nax is an atypical sodium channel that mediates inflammatory pathways in pathological conditions of the skin. In this study, we developed a skin inflammation model in the rabbit ear through application of imiquimod (IMQ). Knockdown of Nax using RNAi attenuated IMQ-induced skin inflammation, including skin erythema, scaling and papule formation. Histologic analysis showed that thickening and insufficient differentiation of the epidermis found in psoriasis-like skin were normalized by administra...
1 CitationsSource