Federica Klaus
University of Zurich
PsychiatryPsychopathologyInternal medicineEndocrinologyOncologyHippocampal formationPsychologyNeuroscienceCognitionTumor necrosis factor alphaEffects of sleep deprivation on cognitive performanceImmunologyApathySocial isolationInflammationAlogiaLoss aversionAvolitionHypomaniaCytokineAnhedoniaDepression (differential diagnoses)AmygdalaAntidepressantPsychosisMajor depressive disorderAntipsychoticReward valueIn patientTreatment targetsStudent populationSubstance abusePeripheralClinical psychologyMedicineSchizophreniaBiology
27Publications
5H-index
287Citations
Publications 20
Newest
#8Mariia Kaliuzhna (Geneva College)H-Index: 10
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Abstract null null Background null Schizophrenia (SZ) and major depressive disorders (MDD) have been frequently linked to anatomical brain alterations. However, the relationship between brain pathology, inflammation and clinical symptoms in these disorders is still unclear. Thus, by applying novel blood markers of neuroaxonal integrity such as neurofilament light chain (NfL), we can now address main issues in psychiatric research and potentially offer innovative diagnostic tools toward better cl...
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#1Flurin Cathomas (UZH: University of Zurich)H-Index: 11
#2Karoline Guetter (UZH: University of Zurich)H-Index: 3
Last. Stefan Kaiser (Geneva College)H-Index: 28
view all 5 authors...
Tryptophan and its catabolites (TRYCATs) have been suggested to link peripheral immune system activation and central neurotransmitter abnormalities with relevance to the etio-pathophysiology of schizophrenia (SZ) and major depressive disorder (MDD). The relationship to different psychopathological dimensions within these disorders however remains to be elucidated. We thus investigated potential group differences of tryptophan, kynurenine, kynurenic acid, 3-hydroxy kynurenine and quinolinic acid ...
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#1Federica Klaus (UCSD: University of California, San Diego)H-Index: 5
#1Federica Klaus (UCSD: University of California, San Diego)
Last. Tanya T. Nguyen (UCSD: University of California, San Diego)H-Index: 16
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ABSTRACT Background Peripheral levels of pro-inflammatory biomarkers have been shown to be altered in schizophrenia (SZ) and associated with cognitive impairments, but their relevance to specific cognitive domains remains unclear. Methods Plasma levels of cytokines, chemokines, and vascular biomarkers were quantified and compared between SZ and healthy comparison (HC) groups. Cognition was assessed using the Delis-Kaplan Executive Function System Trail Making (TM) and Color Word Interference (CW...
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#1Federica Klaus (UCSD: University of California, San Diego)H-Index: 5
#1Federica Klaus (UCSD: University of California, San Diego)H-Index: 1
Last. Lisa T. EylerH-Index: 47
view all 7 authors...
Introduction The coronavirus pandemic and resulting restrictions of social activity have the potential to differentially affect older adults. People over 65 years old are at increased vulnerability to COVID-19 compared to younger adults, which may increase anxiety and efforts to socially isolate. In addition, older adults may be uniquely affected by smaller social networks or less access to technological substitutes for social interactions. While a recent study on mental well-being among older a...
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#1Flurin Cathomas (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 11
#2Federica Klaus (UCSD: University of California, San Diego)H-Index: 5
Last. Philippe N. Tobler (UZH: University of Zurich)H-Index: 40
view all 11 authors...
One aspect of goal-directed behavior, which is known to be impaired in patients with schizophrenia (SZ), is balancing between exploiting a familiar choice with known reward value and exploring a lesser known, but potentially more rewarding option. Despite its relevance to several symptom domains of SZ, this has received little attention in SZ research. In addition, while there is increasing evidence that SZ is associated with chronic low-grade inflammation, few studies have investigated how this...
2 CitationsSource
#1Federica Klaus (UCSD: University of California, San Diego)H-Index: 5
#1Federica Klaus (UCSD: University of California, San Diego)H-Index: 1
Last. Stefan Kaiser (Geneva College)H-Index: 28
view all 8 authors...
Abstract Increasing evidence points to a causal involvement of inflammation in the pathogenesis of neuropsychiatric disorders, including major depressive disorder (MDD) and schizophrenia (SZ). Neopterin and biopterin may link peripheral immune system activation and central neurotransmitter alterations. However, it is not fully established whether these alterations are transdiagnostic or disorder-specific and whether they are associated with reward-related psychopathologies. We investigated group...
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#1Federica Klaus (UZH: University of Zurich)H-Index: 5
#2Justin R. Chumbley (UZH: University of Zurich)H-Index: 13
Last. Matthias N Hartmann-Riemer (UZH: University of Zurich)H-Index: 7
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In the field of behavioral decision-making, "loss aversion" is a behavioral phenomenon in which individuals show a higher sensitivity to potential losses than to gains. Conversely, "risk averse" individuals have an enhanced sensitivity/aversion to options with uncertain consequences. Here we examine whether hypomania or negative symptoms predict the degree of these choice biases. We chose to study these two symptom dimensions because they present a common theme across many syndromes with comprom...
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#1Flurin Cathomas (UZH: University of Zurich)H-Index: 11
#2Federica Klaus (UZH: University of Zurich)H-Index: 5
Last. Stefan Kaiser (University of Geneva)H-Index: 28
view all 11 authors...
One aspect of goal-directed behavior, which is known to be impaired in patients with schizophrenia (SZ), is balancing between exploiting a familiar choice with known reward value and exploring a lesser known but potentially more rewarding option. Despite its relevance to several symptom domains of SZ, this has received little attention in SZ research. In addition, while there is increasing evidence that SZ is associated with chronic low-grade inflammation, few studies have investigated how this ...
1 CitationsSource