Celina Yang
Ryerson University
Colloidal goldConjugated systemCancerBiophysicsCellNanomedicineNanoparticleNanotechnologyChemistryMaterials scienceIn vitroBleomycinChemotherapyPeptideDrug deliveryNano-Anticancer drugCancer researchRadiation therapyCancer cellPharmacologyDistribution (pharmacology)
24Publications
8H-index
209Citations
Publications 24
Newest
#1Elyas Shaswary (RyeU: Ryerson University)H-Index: 2
#2Hisham Assi (RyeU: Ryerson University)H-Index: 1
Last. Jahan Tavakkoli (RyeU: Ryerson University)H-Index: 13
view all 7 authors...
Abstract Purpose A real-time and non-invasive thermometry technique is essential in thermal therapies to monitor and control the treatment. Ultrasound is an attractive thermometry modality due to its relatively high sensitivity to change in temperature and fast data acquisition and processing capabilities. A temperature-sensitive acoustic parameter is required for ultrasound thermometry in order to track the changes in that parameter during the treatment. Currently, the main ultrasound thermomet...
Source
Objective This work aims to determine whether photoacoustic (PA) thermometry from a commercially available PA imaging system can be used to control the temperature in nanoparticle-mediated thermal therapies. Methods The PA imaging system was interfaced to obtain PA images while scanning ex-vivo tissue. These images were then used to obtain temperature maps in real-time during heating. Validation and calibration of the PA thermometry were done using a fluoroptic thermometer. This thermometer was ...
Source
#1Celina Yang (RyeU: Ryerson University)H-Index: 8
#2Kyle Bromma (UVic: University of Victoria)H-Index: 7
Last. Devika B. Chithrani (RyeU: Ryerson University)H-Index: 17
view all 5 authors...
Combined use of chemotherapy and radiation therapy is commonly used in cancer treatment, but the toxic effects on normal tissue are a major limitation. This study assesses the potential to improve radiation therapy when combining gold nanoparticle (GNP) mediated radiation sensitization with chemoradiation compared to chemoradiation alone. Incorporation of GNPs with 2 Gy, 6 MV (megavoltage) radiation resulted in a 19 ± 6% decrease in survival of MDA-MB-231 cells. Monte-Carlo simulations were perf...
15 CitationsSource
#1Celina Yang (RyeU: Ryerson University)H-Index: 8
#2Kyle Bromma (UVic: University of Victoria)H-Index: 7
Last. Devika B. Chithrani (RyeU: Ryerson University)H-Index: 17
view all 6 authors...
The combined use of radiation therapy and chemotherapy is commonly being used in cancer treatment. The side effects of the treatment can be further minimized through targeted delivery of anticancer drugs and local enhancement of the radiation dose. Gold nanoparticles (GNPs) can play a significant role in this regard since GNPs can be used as radiation dose enhancers and anticancer drug carriers. Anticancer drug, bleomycin, was chosen as the model drug, since it could be easily conjugated onto GN...
18 CitationsSource
#1Celina Yang (RyeU: Ryerson University)H-Index: 8
#2Kyle Bromma (UVic: University of Victoria)H-Index: 7
Last. Devika B. Chithrani (RyeU: Ryerson University)H-Index: 17
view all 3 authors...
Optimizing the interface between nanoparticles (NPs) and the biological environment at various levels should be considered for improving delivery of NPs to the target tumor area. For NPs to be successfully delivered to cancer cells, NPs needs to be functionalized for circulation through the blood vessels. In this study, accumulation of Polyethylene Glycol (PEG) functionalized gold nanoparticles (GNPs) was first tested using in vitro monolayer cells and multilayer cell models prior to in vivo mod...
15 CitationsSource
#1Celina Yang (RyeU: Ryerson University)H-Index: 8
#2Kyle Bromma (UVic: University of Victoria)H-Index: 7
Last. B. D. Chithrani (RyeU: Ryerson University)H-Index: 2
view all 3 authors...
Recent developments in nanotechnology has provided new tools for cancer therapy and diagnosis. Among other nanomaterial systems, gold nanoparticles are being used as radiation dose enhancers and anticancer drug carriers in cancer therapy. Fate of gold nanoparticles within biological tissues can be probed using techniques such as TEM (transmission electron microscopy) and SEM (Scanning Electron Microscopy) due to their high electron density. We have shown for the first time that cancer drug loade...
Source
#1Celina Yang (RyeU: Ryerson University)H-Index: 8
#2B. D. Chithrani (RyeU: Ryerson University)H-Index: 2
Nanoparticles can be used to overcome the side effects due to poor distribution of anticancer drugs. Among other NPs, colloidal gold nanoparticles (GNPs) offer the possibility of transporting major quantities of drugs due to their large surface-to volume ratio while confining anticancer drugs as closely as possible to their biological targets through passive and active targeting ensuring limited harmful systemic distribution. In this study, we chose bleomycin (BLM) as the anticancer drug since i...
Source
#1Celina Yang (RyeU: Ryerson University)H-Index: 8
#2Jamie UertzH-Index: 1
Last. Devika B. Chithrani (RyeU: Ryerson University)H-Index: 17
view all 3 authors...
Nanoparticles (NPs) can be used to overcome the side effects of poor distribution of anticancer drugs. Among other NPs, colloidal gold nanoparticles (GNPs) offer the possibility of transporting major quantities of drugs due to their large surface-to-volume ratio. This is while confining these anticancer drugs as closely as possible to their biological targets through passive and active targeting, thus ensuring limited harmful systemic distribution. In this study, we chose to use bleomycin (BLM) ...
7 CitationsSource
#1Darren Yohan (RyeU: Ryerson University)H-Index: 8
#2Celina Yang (RyeU: Ryerson University)H-Index: 8
Last. Devika B. Chithrani (RyeU: Ryerson University)H-Index: 17
view all 4 authors...
Gold nanoparticles (GNPs) are emerging as a novel tool to improve existing cancer therapeutics. GNPs are being used as radiation dose enhancers in radiation therapy as well as anticancer drugs carriers in chemotherapy. However, the success of GNP-based therapeutics depends on their ability to penetrate tumor tissue. GNPs of 20 and 50 nm diameters were used to elucidate the effects of size on the GNP interaction with tumor cells at monolayer and multilayer level. At monolayer cell level, smaller ...
2 CitationsSource
#1Celina Yang (RyeU: Ryerson University)H-Index: 8
#2Devika B. Chithrani (RyeU: Ryerson University)H-Index: 17
Nanoparticles have been used as a platform to improve therapeutic results in medical research. Gold nanoparticles (GNPs) have been extensively studied among other nanoparticles in cancer research due to its property being radio-sensitizing by producing more secondary electrons in response to irradiation. It is predicted that closer the GNPs can get to the DNA, the extra secondary electrons will cause more breaks in the DNA.However, the regular uptake pathway of GNPs into the cell is known to be ...
1 CitationsSource