María-Julieta González
University of Chile
Internal medicineEndocrinologyUnfolded protein responsePathologyMolecular biologyEndoplasmic reticulumReceptorMucinImmunologyInflammationCytokineSalivary glandBasal laminaUlcerative colitisIntestinal mucosaSecretionCancer researchSalivaMedicineBlotBiologyCell biology
65Publications
21H-index
1,775Citations
Publications 78
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#1María-José Barrera (San Sebastián University)H-Index: 3
Relevant reviews highlight the association between dysfunctional mitochondria and inflammation, but few studies address the contribution of mitochondria and mitochondria-endoplasmic reticulum (ER) contact sites (MERCs) to cellular homeostasis and inflammatory signaling. The present review outlines the important role of mitochondria in cellular homeostasis and how dysfunctional mitochondrion can release and misplace mitochondrial components (cardiolipin, mitochondrial DNA (mtDNA), and mitochondri...
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#4María-José Barrera (San Sebastián University)H-Index: 3
#6Sergio González (Universidad Mayor)H-Index: 13
Last. Claudio Molina (San Sebastián University)H-Index: 4
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#1Daniela JaraH-Index: 4
#2S. AguileraH-Index: 6
Last. María-Julieta González (University of Chile)H-Index: 21
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#1María-José Barrera (San Sebastián University)H-Index: 3
#1María-José Barrera (San Sebastián University)H-Index: 2
Last. María-Julieta González (University of Chile)H-Index: 21
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Objective Altered homeostasis of salivary gland (SG) epithelial cells in Sjogren's syndrome (SS) could be the initiating factor that leads to inflammation, secretory dysfunction and autoimmunity. Autophagy is an important homeostatic mechanism, whose deficiency is associated with inflammation and accumulation of Janus kinase (JAK)-signal transducer and activator of transcription (STAT) components. We aimed to evaluate whether autophagy is altered in labial SG (LSG) epithelial cells from primary ...
3 CitationsSource
#1Martín González Cañete (University of Los Andes)H-Index: 1
#2Isidora Mujica Valenzuela (University of Los Andes)H-Index: 1
Last. Sergio González Providell (University of Los Andes)H-Index: 1
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ABSTRACT Objectives : This systematic review aims to describe the value of saliva as a non-invasive sample for the detection of SARS-CoV-2, in comparison with the current method for sample collection, the nasopharyngeal swabs. Methods : We conducted a systematic review of the literature, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations. We searched in 5 databases: PubMed, Cochrane, EBSCO, Elsevier, and MEDLINE, and included articles publis...
2 CitationsSource
#1Ignacio N. Retamal (University of Los Andes)H-Index: 6
#1Ignacio N Retamal (University of Los Andes)H-Index: 1
Last. Patricio C. Smith (UC: Pontifical Catholic University of Chile)H-Index: 22
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OBJECTIVES: Myofibroblasts constitute a specific cell phenotype involved in connective tissue healing. Diabetes alters the wound healing response. However, it is not clear whether diabetes modifies the involvement of myofibroblasts in periodontal wounds. MATERIAL AND METHODS: Type I diabetes was induced in rats through streptozotocin injection and periodontal wounds were performed. Wound healing was evaluated histologically at 2, 5, 7 and 15 days by measuring epithelial migration, neutrophil inf...
3 CitationsSource
#1Patricia Carvajal (University of Chile)H-Index: 6
#2S. AguileraH-Index: 6
Last. María-Julieta González (University of Chile)H-Index: 21
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Background: The approach from the point of view of the evolutionary perspective of finding targets for therapeutic effects among the components of the cellular destruction system is critical both in the treatment of rheumatological diseases and in gerontology. Objectives: To identify the relationships between the pathways of cell death in synovial fluid (SF) of people of different age groups with SDCT. Methods: SF was analyzed in patients of two age groups. Group N 1 of patients: 10 SLE (43±2.3 ...
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#1Isabel CastroH-Index: 11
#2Nicolás Albornoz (University of Chile)H-Index: 2
Last. María-Julieta González (University of Chile)H-Index: 21
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OBJECTIVES: Xerostomia in SS patients has been associated with low quality and quantity of salivary mucins, which are fundamental for the hydration and protection of the oral mucosa. The aim of this study was to evaluate if cytokines induce aberrant mucin expression and whether tauroursodeoxycholic acid (TUDCA) is able to counteract such an anomaly. METHODS: Labial salivary glands from 16 SS patients and 15 control subjects, as well as 3D acini or human submandibular gland cells stimulated with ...
9 CitationsSource
#1Karen Dubois-Camacho (University of Chile)H-Index: 6
#2David Díaz-Jiménez (University of Chile)H-Index: 9
Last. Marcela A. Hermoso (University of Chile)H-Index: 26
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Ulcerative colitis (UC) is an inflammatory bowel disease (IBD) characterized by mucosa damage associated to an uncontrolled inflammatory response. This immunological impairment leads to altered inflammatory mediators such as IL-33, which is shown to increase in the mucosa of active UC (aUC) patients. MicroRNAs present a distorted feature in inflamed colonic mucosa and are potential IL-33 regulating candidates in UC. Therefore, we studied the microRNA and mRNA profiles in inflamed colonic samples...
9 CitationsSource