Giulia Russo
University of Naples Federico II
PhysicsCancerInternal medicineMolecular biologyAtomic physicsNuclear physicsChemistryVaccinationIn silicoDiseaseTuberculosisRibosomal proteinComputer scienceCancer researchBiochemistryComputational biologyMedicineBiologyImmune systemCell biologyCancer cell
197Publications
27H-index
2,171Citations
Publications 144
Newest
#1Antonella Virgilio (University of Naples Federico II)H-Index: 21
#2Daniela Benigno (University of Naples Federico II)
Last. Aldo Galeone (University of Naples Federico II)H-Index: 26
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In this paper, we report our investigations on five T30175 analogues, prepared by replacing sequence thymidines with abasic sites (S) one at a time, in comparison to their natural counterpart in order to evaluate their antiproliferative potential and the involvement of the residues not belonging to the central core of stacked guanosines in biological activity. The collected NMR (Nuclear Magnetic Resonance), CD (Circular Dichroism), and PAGE (Polyacrylamide Gel Electrophoresis) data strongly sugg...
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#1Giovanni B. ForleoH-Index: 26
#2A Gasperetti (Johns Hopkins University)
Last. Agostino Piro (Policlinico Umberto I)
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Abstract null Background null To date, only few comparisons between subcutaneous implantable cardioverter defibrillator (S-ICD) patients undergoing vs. not undergoing defibrillation testing (DT) at implantation (DT+ vs DT-) have been reported. null Objective null Aim of the study was to compare long-term clinical outcomes of two propensity-matched cohorts of DT+ and DT- patients. null Methods null Among consecutive S-ICD patients, implanted across 17 centers from January 2015 to October 2020, DT...
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The term In Silico Trial indicates the use of computer modelling and simulation to evaluate the safety and efficacy of a medical product, whether a drug, a medical device, a diagnostic product or an advanced therapy medicinal product. Predictive models are positioned as new methodologies for the development and the regulatory evaluation of medical products. New methodologies are qualified by regulators such as FDA and EMA through formal processes, where a first step is the definition of the Cont...
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#1Giulia Russo (University of Catania)H-Index: 27
#2Valentina Di Salvatore (University of Catania)H-Index: 3
Last. Francesco Pappalardo (University of Catania)H-Index: 23
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The value of in silico methods in drug development and evaluation has been demonstrated repeatedly and convincingly. While their benefits are now unanimously recognized, international standards for their evaluation, accepted by all stakeholders involved, are still to be established. In this white paper, we propose a risk-informed evaluation framework for mechanistic model credibility evaluation. To properly frame the proposed verification and validation activities, concepts such as context of us...
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#1Annalisa Pecoraro (University of Naples Federico II)H-Index: 4
#2Martina Pagano (University of Naples Federico II)H-Index: 1
Last. Annapina Russo (University of Naples Federico II)H-Index: 23
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Cytosolic ribosomes (cytoribosomes) are macromolecular ribonucleoprotein complexes that are assembled from ribosomal RNA and ribosomal proteins, which are essential for protein biosynthesis. Mitochondrial ribosomes (mitoribosomes) perform translation of the proteins essential for the oxidative phosphorylation system. The biogenesis of cytoribosomes and mitoribosomes includes ribosomal RNA processing, modification and binding to ribosomal proteins and is assisted by numerous biogenesis factors. T...
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#1M. Cavallaro (INFN: Istituto Nazionale di Fisica Nucleare)H-Index: 26
#2J. I. Bellone (INFN: Istituto Nazionale di Fisica Nucleare)H-Index: 4
Last. V. A. B. Zagatto (Federal Fluminense University)H-Index: 8
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The 40Ca(18O,18F)40K single charge exchange (SCE) reaction is explored at 275 MeV incident energy and analyzed consistently with elastic and inelastic scattering data collected in the same experimental conditions. Fully quantum mechanical SCE calculations of the direct mechanism are performed including microscopic nuclear structure inputs and adopting either a bare optical potential or a coupled channel equivalent polarization potential constrained by elastic and inelastic data. The direct SCE m...
1 CitationsSource
#1Cristina Curreli (UNIBO: University of Bologna)H-Index: 3
#2Francesco Pappalardo (University of Catania)H-Index: 5
Last. Marco Viceconti (UNIBO: University of Bologna)H-Index: 67
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Agent-Based Models are a powerful class of computational models widely used to simulate complex phenomena in many different application areas. However, one of the most critical aspects, poorly investigated in the literature, regards an important step of the model credibility assessment: solution verification. This study overcomes this limitation by proposing a general verification framework for Agent-Based Models that aims at evaluating the numerical errors associated with the model. A step-by-s...
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#1Giuseppe Sgroi (University of Catania)H-Index: 3
#2Giulia Russo (University of Catania)H-Index: 27
Last. Francesco Pappalardo (University of Catania)H-Index: 23
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SUMMARY Although several bioinformatics tools have been developed to examine signaling pathways, little attention has been given to ever long-distance crosstalk mechanisms. Here, we developed PETAL, a Python tool that automatically explores and detects the most relevant nodes within a KEGG pathway, scanning and performing an in-depth search. PETAL can contribute to discovering novel therapeutic targets or biomarkers that are potentially hidden and not considered in the network under study. AVAIL...
2 CitationsSource
The term "In Silico Trial" indicates the use of computer modelling and simulation to evaluate the safety and efficacy of a medical product, whether a drug, a medical device, a diagnostic product or an advanced therapy medicinal product. Predictive models are positioned as new methodologies for the development and the regulatory evaluation of medical products. New methodologies are qualified by regulators such as FDA and EMA through formal processes, where a first step is the definition of the Co...