Haroon Khan
Abdul Wali Khan University Mardan
CancerChemistryPhytochemicalIn vitroIn vivoOxidative stressAntioxidantDiseaseAnti-inflammatoryEthyl acetateChromatographyCancer researchGlutathioneBiochemistryTraditional medicineBotanyBioinformaticsAgronomyMedicineBiologyPharmacology
Publications 418
#1Dapinder Kaur (Chitkara University)H-Index: 1
#2Tapan Behl (Chitkara University)H-Index: 14
Last. Ahmed Suleiman Alharassi (University of Nizwa)H-Index: 1
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During the last three decades, recombinant DNA technology has produced a wide range of hematopoietic and neurotrophic growth factors, including erythropoietin (EPO), which has emerged as a promising protein drug in the treatment of several diseases. Cumulative studies have recently indicated the neuroprotective role of EPO in preclinical models of acute and chronic neurodegenerative disorders, including Alzheimer's disease (AD). AD is one of the most prevalent neurodegenerative illnesses in the ...
#1Salman Ahmed (KU: University of Karachi)H-Index: 8
#2Hamed Mirzaei (KAUMS: Kashan University of Medical Sciences)H-Index: 59
Last. Haroon Khan (AWKUM: Abdul Wali Khan University Mardan)H-Index: 34
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Breast cancer is the most prevalent invasive form of cancer in females and posing a great challenge for overcoming disease burden. The growth in global cancer deaths mandates the discovery of new efficacious natural anti-tumor treatments. In this regard, aquatic species offer a rich supply of possible drugs. Studies have shown that several marine peptides damage cancer cells by a broad range of pathways, including apoptosis, microtubule balance disturbances, and suppression of angiogenesis. Trad...
#1Muhammad Ajmal Shah (GCUF: Government College University, Faisalabad)H-Index: 16
#2Azhar Rasul (GCUF: Government College University, Faisalabad)H-Index: 26
Last. Gaber El-Saber Batiha (Damanhour University)H-Index: 13
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The flare-up in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that emerged in December 2019 in Wuhan, China, and spread expeditiously worldwide has become a health challenge globally. The rapid transmission, absence of anti-SARS-CoV-2 drugs, and inexistence of vaccine are further exacerbating the situation. Several drugs, including chloroquine, remdesivir, and favipiravir, are presently undergoing clinical investigation to further scrutinize their effectiveness and validity in the...
#1Sajad Fakhri (Kermanshah University of Medical Sciences)H-Index: 12
#2Sana Piri (Kermanshah University of Medical Sciences)H-Index: 1
Last. Haroon Khan (AWKUM: Abdul Wali Khan University Mardan)H-Index: 34
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Background null Withania somnifera (WS), also known as Ashwagandha, is commonly used in Ayurveda and other traditional medicine systems. WS has seen growing, worldwide use by the public due to its reputation as an adaptogen. This popularity has elicited increased scientific study of its biological effects, including a potential application for neuropsychiatric and neurodegenerative disorders. null Objective null This review aims to provide a comprehensive summary of preclinical and clinical stud...
#1Yaseen Hussain (Soochow University (Suzhou))H-Index: 3
#2Lubna Islam (University of Malakand)
Last. Saba Javed (HU: Hazara University)
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The efficacy of chemotherapy in cancer therapy is limited due to resistance, treatment selectivity, and severe adverse effects. Immunotherapy, chemotherapy, targeted therapy, radiation, and surgery are the most common therapeutic strategies for treatment, with chemotherapy being the most successful. Nonetheless, these treatments exhibit poor effectiveness due to toxicity and resistance. Therefore, combination therapies of natural products may be used as an effective and novel strategy to overcom...
#1Iqbal Wadan (Gomal University)
#2Haroon Khan (Gomal University)H-Index: 34
Last. Barkat Ali Khan (Gomal University)H-Index: 6
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#1Waqas Alam (AWKUM: Abdul Wali Khan University Mardan)H-Index: 1
#2Hammad Ullah (University of Naples Federico II)H-Index: 10
Last. Carla Renata Arciola (UNIBO: University of Bologna)H-Index: 65
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Colorectal carcinogenesis is the second most common cause of mortality across all types of malignancies, followed by hepatic and stomach cancers. Chemotherapy and radiotherapy are key approaches to treating cancer patients, but these carry major concerns, such as a high risk of side effects, poor accessibility, and the non-selective nature of chemotherapeutics. A number of natural products have been identified as countering various forms of cancer with fewer side effects. The potential impact of...
#1Yan Zhou (UM: University of Macau)
#1Yan Zhou (UM: University of Macau)
Last. Wai San Cheang (UM: University of Macau)H-Index: 18
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In different pathological states that cause endoplasmic reticulum (ER) calcium depletion, altered glycosylation, nutrient deprivation, oxidative stress, DNA damage or energy perturbation/fluctuations, the protein folding process is disrupted and the ER becomes stressed. Studies in the past decade have demonstrated that ER stress is closely associated with pathogenesis of obesity, insulin resistance and type 2 diabetes. Excess nutrients and inflammatory cytokines associated with metabolic disease...
#1Philippe JeandetH-Index: 50
#2Alessandro Vannozzi (UNIPD: University of Padua)H-Index: 12
Last. Seyed Mohammad Nabavi (BMSU: Baqiyatallah University of Medical Sciences)H-Index: 65
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Covering: 1976 to 2020.Although constituting a limited chemical family, phytostilbenes represent an emblematic group of molecules among natural compounds. Ever since their discovery as antifungal compounds in plants and their ascribed role in human health and disease, phytostilbenes have never ceased to arouse interest for researchers, leading to a huge development of the literature in this field. Owing to this, the number of references to this class of compounds has reached the tens of thousand...
10 CitationsSource
#1Sepideh Mirzaei (IAU: Islamic Azad University, Science and Research Branch, Tehran)H-Index: 5
#2Asal Jalal Abadi (IAU: Islamic Azad University)H-Index: 2
Last. Haroon Khan (AWKUM: Abdul Wali Khan University Mardan)H-Index: 34
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Considering the fact that cancer cells can switch among various molecular pathways and mechanisms to ensure their progression, chemotherapy is no longer effective enough in cancer therapy. As an anti-tumor agent, doxorubicin (DOX) is derived from Streptomyces peucetius and can induce cytotoxicity by binding to topoisomerase enzymes to suppress DNA replication, leading to apoptosis and cell cycle arrest. However, efficacy of DOX in suppressing cancer progression is restricted by development of dr...