John A. Peters
University of Dundee
Protein subunitBiophysicsEndocrinologyAllosteric regulationGABAA receptorNeuroscienceReceptorElectrophysiologyChemistryCys-loop receptors5-HT3 receptorGlycine receptorNeuroactive steroidIon channelBiochemistryStereochemistryBiologyGABAA-rho receptorCell biologyPharmacology
179Publications
73H-index
19.3kCitations
Publications 155
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#2Eamonn KellyH-Index: 43
Last. Jamie A. DaviesH-Index: 54
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#1Stephen P.H. Alexander (University of Nottingham)H-Index: 56
#2Eamonn KellyH-Index: 43
Last. Jamie A. Davies (Edin.: University of Edinburgh)H-Index: 54
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The Concise Guide to PHARMACOLOGY 2019/20 is the fourth in this series of biennial publications. The Concise Guide provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide represents approximately 400 ...
137 CitationsSource
#1Paul DaviesH-Index: 41
#2Tim G. HalesH-Index: 36
Last. John A. PetersH-Index: 73
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#1Nicholas M. Barnes (University of Birmingham)H-Index: 37
#2Tim G. Hales (Dund.: University of Dundee)H-Index: 36
Last. John A. Peters (Dund.: University of Dundee)H-Index: 73
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The 5-HT3 receptor (nomenclature as agreed by the NC-IUPHAR Subcommittee on 5-Hydroxytryptamine (serotonin) receptors [66]) is a ligand-gated ion channel of the Cys-loop family that includes the zinc-activated channels, nicotinic acetylcholine, GABAA and strychnine-sensitive glycine receptors. The receptor exists as a pentamer of 4TM subunits that form an intrinsic cation selective channel [5]. Five human 5-HT3 receptor subunits have been cloned and homo-oligomeric assemblies of 5-HT3A and heter...
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#1Delia Belelli (Dund.: University of Dundee)H-Index: 44
#1Delia BelelliH-Index: 1
Last. Werner SieghartH-Index: 71
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#1Rodrigo Andrade (WSU: Wayne State University)H-Index: 28
#2Nicholas M. Barnes (University of Birmingham)H-Index: 37
Last. Frank D. YoccaH-Index: 23
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5-HT receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on 5-HT receptors [194] and subsequently revised [176]) are, with the exception of the ionotropic 5-HT3 class, GPCRs where the endogenous agonist is 5-hydroxytryptamine. The diversity of metabotropic 5-HT receptors is increased by alternative splicing that produces isoforms of the 5-HT2A (non-functional), 5-HT2C (non-functional), 5-HT4, 5-HT6 (non-functional) and 5-HT7 receptors. Unique amongst the GPCRs, RNA editing produces 5...
2 CitationsSource
#1Delia Belelli (Dund.: University of Dundee)H-Index: 44
#2Tim G. Hales (Dund.: University of Dundee)H-Index: 36
Last. Werner Sieghart (Medical University of Vienna)H-Index: 71
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#1Stephen P.H. Alexander (University of Nottingham)H-Index: 56
#2Eamonn KellyH-Index: 43
Last. Jamie A. DaviesH-Index: 54
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161 CitationsSource
#1Arthur Christopoulos (Monash University)H-Index: 76
#2Jean-Pierre Changeux (Pasteur Institute)H-Index: 128
Last. Christopher J. Langmead (Monash University)H-Index: 29
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Allosteric interactions play vital roles in metabolic processes and signal transduction and, more recently, have become the focus of numerous pharmacological studies because of the potential for discovering more target-selective chemical probes and therapeutic agents. In addition to classic early studies on enzymes, there are now examples of small molecule allosteric modulators for all superfamilies of receptors encoded by the genome, including ligand- and voltage-gated ion channels, G protein–c...
138 CitationsSource
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