Shaofei Wang
Fudan University
CytotoxicityArginaseChemistryApoptosisAutophagyIn vivoInflammasomeGrowth inhibitionCD47ToxicityProgrammed cell deathReactive oxygen speciesCancer researchBiochemistryDendrimerCell growthSignal transductionMedicineProtein kinase BPI3K/AKT/mTOR pathwayBiologyHedgehog signaling pathwayCell biologyPharmacology
40Publications
18H-index
859Citations
Publications 38
Newest
#1Shaofei WangH-Index: 18
#2Yubin LiH-Index: 18
Last. Dianwen JuH-Index: 34
view all 3 authors...
The extensive application of nanoparticles in diverse fields, ranging from agricultural, environmental, computational, and industrial sciences to pharmaceutical and biomedical sciences, is expected to revolutionize many aspects of human life. With the continuous development of nanotechnology, the medical application of nanomaterials has gained increasing interests from both academic and industrial communities. Various functionalized nanomaterials, such as molecular imaging biomarkers and biosens...
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#1Yubin Li (UPenn: University of Pennsylvania)H-Index: 18
#2Shaofei Wang (Fudan University)H-Index: 18
Last. Dianwen Ju (Fudan University)H-Index: 34
view all 3 authors...
Abstract Because of monodispersity, unique structure, and tunable properties, polymeric nanomaterials are widely used for theranostic purposes and have been developed as antipathogen/antitumor agents. The application of polymeric nanomaterials in pharmaceutical filed has been highly expected to change the landscape of medical research industry in the near future, but the toxicity of polymeric nanomaterials has become a serious challenge during application and related mechanisms, which have been ...
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#1Jingyun Luan (Fudan University)H-Index: 15
#2Wei Chen (Fudan University)H-Index: 15
Last. Dianwen Ju (Fudan University)H-Index: 34
view all 12 authors...
Abstract Excessive release of interleukin-1β (IL-1β) is well-known to provoke cascades of inflammatory responses thus contributing to the pathogenesis of alcohol-induced steatohepatitis (ASH), but the cellular mechanism that regulates IL-1β release during ASH remains unclear. Herein, we identified that gasdermin D (GSDMD) membrane pore is critical in mediating IL-1β hypersecretion from chronic ethanol or acetaldehyde-stimulated macrophages. Deletion of GSDMD reduced IL-1β release and ameliorated...
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#4Wei Chen (Fudan University)H-Index: 15
#9Li Ye (Fudan University)H-Index: 13
Background Inhibitors targeting VEGF and VEGFR are commonly used in the clinic, but only a subset of patients could benefit from these inhibitors and the efficacy was limited by multiple relapse mechanisms. In this work, we aimed to investigate the role of innate immune response in anti-angiogenic therapy and explore efficient therapeutic strategies to enhance efficacy of anti-angiogenic therapy against non-small cell lung cancer (NSCLC).
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#1Shaofei Wang (Fudan University)H-Index: 18
Abstract Background Due to their intrinsic thermal and magnetic resonance imaging properties, magnetic nanoparticles (MNCs) have attracted more and more attention in the biomedical field. However, relatively weak photothermal conversion (PTC) efficiency and low tumor homing capacity has hampered its further application in vivo. Methods To solve these problems, we modified near-infrared (NIR) light-absorbing materials onto the surface of MNCs to increase PTC efficiency and increase MNCs tumor hom...
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#1Shaofei Wang (Fudan University)H-Index: 18
#2Jiajun Fan (Fudan University)H-Index: 22
Last. Dianwen Ju (Fudan University)H-Index: 34
view all 10 authors...
Aristolochic acid nephropathy (AAN), as a rapidly progressive interstitial nephropathy due to excessive ingestion of aristolochia herbal medications, has recently raised considerable concerns among clinicians and researchers with its underlying pathogenic mechanisms largely unclear. In the current study, we identified NLRP3 inflammasome activation as a novel pathological mechanism of AAN. We found that NLRP3 inflammasome was aberrantly activated both in vivo and in vitro after AA exposure. Block...
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#9Li Li (Fudan University)H-Index: 7
Lung adenocarcinoma (LUAD), which comprises over 50% of all cases of non-small-cell lung cancer, has a poor prognosis and requires novel therapeutic approaches. The sonic Hedgehog (Shh) pathway, which plays a crucial role in differentiation, proliferation, and survival of cancer cells, is likely to be activated in LUADs, suggesting the Shh pathway as a potential therapeutic target for LUAD treatment. In this study, we reported that vismodegib, an inhibitor of the Shh pathway, only elicited minor...
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#1Ziyu Wang (Fudan University)H-Index: 16
#2Ping Song (Fudan University)H-Index: 12
Last. Dianwen Ju (Fudan University)H-Index: 34
view all 11 authors...
Arginase I has been documented to impair T cell function and attenuate cellular immunity, however, there is little evidence to reveal the effect of arginase I on macrophage function. Recently, recombinant human arginase I (rhArg) has been developed for cancer therapy and is in clinical trial for hepatocellular carcinoma, whereas the potential immunosuppression induced by rhArg limited its therapeutic efficacy. To improve the clinical outcome of rhArg, addressing the immune suppression appears to...
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#1Wei Chen (Fudan University)H-Index: 15
#2Jingyun Luan (Fudan University)H-Index: 15
Last. Dianwen Ju (Fudan University)H-Index: 34
view all 14 authors...
Abstract Hepatocellular injury is the pathological hallmark of hepatitis and a crucial driver for the progression of liver diseases, while the treatment options are commonly restricted. Interleukin-22 (IL-22) has attracted special attention as a potent survival factor for hepatocytes that both prevents and repairs the injury of hepatocytes through activation of STAT3 signaling pathway. We hypothesized that the ability to generate potent expression of IL-22 locally for the treatment of severe hep...
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#1Yichen Wang (Fudan University)H-Index: 12
#2Xuyao Zhang (Fudan University)H-Index: 17
Last. Dianwen Ju (Fudan University)H-Index: 34
view all 11 authors...
Antibody drug conjugate (ADC) showed potent therapeutic efficacy in several types of cancers. The role of autophagy in anti-tumor effects of ADC remains unclear. In this study, a novel ADC, Rituximab-monomethyl auristatin E (MMAE) with a Val-Cit cleavable linker, was designed to investigate its therapeutic efficacy against Non-Hodgkin Lymphoma (NHL) as well as the underlying mechanisms. Our results showed that Rituximab-MMAE elicited caspase-3-dependent apoptosis in NHL cells and exhibited poten...
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