Stella Tinelli
University of Padua
CytotoxicityChemical synthesisBiological activityOligonucleotideCleavage (embryo)TopoisomeraseMolecular biologyCytotoxic T cellMolecular modelChemistryIn vitroMechanism of actionCisplatinCamptothecinDoxorubicinTopoisomerase-II InhibitorCancer researchDNABiochemistryStereochemistryCell cultureTernary complexBiologyPharmacology
49Publications
22H-index
1,946Citations
Publications 47
Newest
#1Serena StamatakosH-Index: 3
Last. Laura GattiH-Index: 27
view all 12 authors...
Metabolic changes promoting cell survival are involved in metastatic melanoma progression and in the development of drug resistance. In BRAF-inhibitor resistant melanoma cells, we explored the role of FASN, an enzyme involved in lipogenesis overexpressed in metastatic melanoma. Resistant melanoma cells displaying enhanced migratory and pro-invasive abilities increased sensitivity to the BRAF inhibitor PLX4032 upon the molecular targeting of FASN and upon treatment with the FASN inhibitor orlista...
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#2Elisabetta VerganiH-Index: 10
Last. Paola PeregoH-Index: 1
view all 7 authors...
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#1Rihan El BezawyH-Index: 3
#2Martina Tripari (University of Liverpool)H-Index: 1
Last. Nadia ZaffaroniH-Index: 66
view all 12 authors...
Speckle-type POZ (pox virus and zinc finger protein) protein (SPOP) is the most commonly mutated gene in prostate cancer (PCa). Recent evidence reports a role of SPOP in DNA damage response (DDR), indicating a possible impact of SPOP deregulation on PCa radiosensitivity. This study aimed to define the role of SPOP deregulation (by gene mutation or knockdown) as a radiosensitizing factor in PCa preclinical models. To express WT or mutant (Y87N, K129E and F133V) SPOP, DU145 and PC-3 cells were tra...
1 CitationsSource
#1Ilda D'AnnessaH-Index: 13
#2Naama Hurwitz (TAU: Tel Aviv University)H-Index: 2
Last. Giorgio ColomboH-Index: 30
view all 11 authors...
The molecular chaperone Hsp90 is a ubiquitous ATPase-directed protein responsible for the activation and structural stabilization of a large clientele of proteins. As such, Hsp90 has emerged as a suitable candidate for the treatment of a diverse set of diseases, such as cancer and neurodegeneration. The inhibition of the chaperone through ATP-competitive inhibitors, however, was shown to lead to undesirable side effects. One strategy to alleviate this problem is the development of molecules that...
5 CitationsSource
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Background Radiotherapy is one of the main treatment options for non-metastatic prostate cancer (PCa). Although treatment technical optimization has greatly improved local tumor control, a considerable fraction of patients still experience relapse due to the development of resistance. Radioresistance is a complex and still poorly understood phenomenon involving the deregulation of a variety of signaling pathways as a consequence of several genetic and epigenetic abnormalities. In this context, c...
28 CitationsSource
#1Paolo GandelliniH-Index: 25
#2Rihan El BezawyH-Index: 3
Last. Nadia ZaffaroniH-Index: 66
view all 8 authors...
Radiotherapy is a standard treatment for organ-confined prostate cancer (PCa). Although treatment technical optimization has greatly improved local tumor control, a significant percentage of patients still undergo recurrence. The onset of radioresistance is a complex phenomenon involving several genetic and epigenetic abnormalities, including the deregulation of microRNAs (miRNAs), endogenous small noncoding RNA molecules that negatively regulate gene expression. In this study, we investigated t...
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#1Nicola Ferri (University of Milan)H-Index: 31
#2Tiziano Radice (University of Milan)H-Index: 2
Last. Alessandro Contini (University of Milan)H-Index: 22
view all 11 authors...
Abstract Bis-2,3-heteroarylmaleimides and polyheterocondensed imides joined through nitrogen atoms of the N , N ′-bis(ethyl)-1,3-propanediamine linker were prepared from substituted maleic anhydrides and symmetrical diamines in good to satisfactory yields and short reaction times using microwave heating. The novel molecules were shown to inhibit proliferation of human tumor cells (NCI-H460 lung carcinoma) and rat aortic smooth muscle cells (SMCs) with variable potencies. Compound 11a , the most ...
20 CitationsSource
#1Sara PizzamiglioH-Index: 22
#2Giacomo CossaH-Index: 15
Last. Paola PeregoH-Index: 54
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The rapid evolution of techniques for measuring gene expression makes available substantial data which require careful analysis. In particular, relative quantification based on microfluidic cards allows performing of rapid large scale analyses. In the present study, we employed ovarian carcinoma cell lines resistant to cisplatin (IGROV-1/Pt1) or to a camptothecin (IGROV-1CPT/L), both characterized by a complex pattern of resistance to multiple agents, to examine the expression of genes of the su...
9 CitationsSource
#1Laura GattiH-Index: 27
#2Giacomo CossaH-Index: 15
Last. Paola PeregoH-Index: 54
view all 10 authors...
Drug resistance represents a major obstacle towards the cure of different tumor types including non‐small cell lung cancer (NSCLC), being one of the main causes of failure of antitumor therapy. Tumor cells frequently exhibit simultaneous resistance to multiple structurally unrelated drugs, a phenotype known as multidrug resistance (MDR). A major cause of the MDR phenotype is the over‐expression of members of a conserved family of transmembrane proteins (ABC transporters). Different structurally ...
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