Fariba Ganji
Tarbiat Modares University
Self-healing hydrogelsBiophysicsBiomedical engineeringNuclear chemistryNanoparticleCopolymerBioavailabilityAqueous solutionChemistryPolymer chemistryMaterials scienceIn vitroBiocompatibilityMesoporous silicaChitosanDrug deliveryVancomycin HydrochlorideChemical engineeringChromatographyScaffoldPharmacology
43Publications
15H-index
657Citations
Publications 45
Newest
#1Fereshteh Kazemi-Aghdam (TMU: Tarbiat Modares University)H-Index: 1
Abstract null null Low mechanical strength and untargeted osteoinduction of chitosan hydrogel limit its application for bone regeneration. This study aimed to develop an injectable chitosan hydrogel with enhanced mechanical strength and improved osteoinductivity for bone tissue engineering. For this purpose, chitosan-modified halloysite nanotubes (mHNTs) were synthesized first. Then, icariin as a bone inducer was loaded into mHNTs (IC@mHNTs), resulting in a sustained drug release system. Further...
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#1Arezou Soroushnia (TMU: Tarbiat Modares University)H-Index: 2
#2Fariba Ganji (TMU: Tarbiat Modares University)H-Index: 15
Last. Hamid MobediH-Index: 17
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Poorly soluble drugs are often a challenging problem in drug formulation. Midazolam is considered one of the best first-line drugs in managing status epilepticus in children who require emergency drug treatment. Owing to poor water solubility, however, oral bioavailability of midazolam is relatively low and insufficient. To improve its dissolution and absorption, nanosuspensions of midazolam hydrochloride were formulated with different stabilizers, such as Tween 80, Poloxamer 188, sodium carboxy...
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#2Ebrahim Vasheghani-Farahani (TMU: Tarbiat Modares University)H-Index: 27
#3Fariba Ganji (TMU: Tarbiat Modares University)H-Index: 15
Last. Alireza Dolatshahi-Pirouz (DTU: Technical University of Denmark)H-Index: 33
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Abstract null null Over the past decades, natural polysaccharides have received considerable attention to developing nano-drug delivery systems for the delivery of anticancer drugs. However, the low solubility of these agents within the biological fluid has reduced their efficacy in inhibiting the growth of cancer cells. In this study, self-assembled cationic polysaccharides based on dextran-stearic acid-spermine conjugates (D-SASp) were synthesized, and their potential as carriers for sustained...
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#1Ameneh Seddighian (TMU: Tarbiat Modares University)H-Index: 1
#2Fariba Ganji (TMU: Tarbiat Modares University)H-Index: 15
Last. Fatemeh Bagheri (TMU: Tarbiat Modares University)H-Index: 14
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The encapsulation of ascorbic acid within chitosan nanoparticles (CHNs), embedded in a fibrous structure of a dexamethasone (Dex)-loaded PCL scaffold, provides a new plan for osteogenic differentiation of mesenchymal stem cells. This electrospun PCL fibrous scaffold can release Dex, as bone differentiation initiator, and ascorbic acid, as bone differentiation enhancer, in an approximately sustained release pattern for about 2 weeks. Ascorbic acid-loaded CHNs were prepared by electrospraying a mi...
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#1Arezou Soroushnia (TMU: Tarbiat Modares University)H-Index: 2
#2Fariba Ganji (TMU: Tarbiat Modares University)H-Index: 15
Last. Hamid MobediH-Index: 17
view all 4 authors...
Midazolam is considered as one of the best first-line drugs in managing status epilepticus in children who require emergency drug treatment. Due to poor water solubility, oral bioavailability of midazolam is relatively low. To improve its dissolution and absorption, midazolam nano-suspensions were formulated with different stabilizers using the ultrasonic technique. A combination of Tween 80 and Poloxamer (TP) was considered as one stabilizer and 3-methyl chitosan (TMC) as another stabilizer. Th...
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#1S. Yousefdoost (Gorgan University)H-Index: 1
#2F. Samadi (Gorgan University)H-Index: 7
Last. Fariba Ganji (Golestan University)H-Index: 15
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Abstract The objective of this study was to evaluate antioxidant and hepatoprotective activities of nanoencapsulated silymarin (NES) against carbon tetrachloride-induced oxidative stress in broiler chickens. An in vitro study was conducted using a 20 kHz ultrasound with 62.5% amplitude to produce NES, stabilized by alginate for controlled release of its bioactive compounds in simulated gastrointestinal tract of broiler chickens. Results showed that sonication reduced the size of particles from 6...
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#1S. YousefdoostH-Index: 1
#2F. SamadiH-Index: 7
Last. S. Hassani (Gorgan University)H-Index: 10
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The main goal of this research was to compare the in vitro release rates of nano- and microcapsules of Silybum marianum extract (SME) in animal simulated gastric and intestinal medium conditions. The extract was encapsulated within sodium alginate carriers using emulsification/internal gelation method. Particle size, zeta potential, polydispersity index (PDI) and morphology of nanocapsules were analysed via dynamic light scattering (DLS) and transmission electron microscopy (TEM). In addition, t...
#1Soudeh Iraji (TMU: Tarbiat Modares University)H-Index: 1
#2Fariba Ganji (TMU: Tarbiat Modares University)H-Index: 15
Last. Ladan Rashidi (USDA: United States Department of Agriculture)H-Index: 14
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Abstract Gallic acid (GA) is a natural and non-enzymatic antioxidant with known anticancer property. In the present work, two types of mesoporous silica nanoparticles (MSNs) were evaluated as a nano carrier for sustained release of GA. For this purpose, amine-functionalized (AP-MSNs) and chitosan coated (CS-MSNs) MSNs were synthesized, loaded by GA and then characterized by SEM, XRD, N2 adsorption isotherms and zeta-potential analysis. Optimum conditions for the loading of GA into the modified M...
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#1Fariba Malekpour-Galogahi (UT: University of Tehran)H-Index: 1
#2Ashrafalasadat Hatamian-Zarmi (UT: University of Tehran)H-Index: 1
Last. Zahra Beagom Mokhtari-Hosseini (HSU: Hakim Sabzevari University)H-Index: 6
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AbstractRivastigmine hydrogen tartrate (RHT) is a pseudo-irreversible inhibitor of cholinesterase and is used for the treatment of Alzheimer's. However, RHT delivery to the brain is limited by the blood–brain barrier (BBB). The purpose of this study was to improve the brain-targeting delivery of RHT by producing and optimizing rivastigmine hydrogen tartrate-loaded tocopherol succinate-based solid lipid nanoparticles (RHT-SLNs). RHT-SLNs were prepared using the microemulsion technique. The impact...
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#1Fatemeh Rezaee (TMU: Tarbiat Modares University)H-Index: 1
#2Fariba Ganji (TMU: Tarbiat Modares University)H-Index: 15
This work aimed to using optimization study to formulate a patient-friendly captopril fast-dissolving oral film with satisfactory disintegration time. Films were made with pullulan and hydroxypropyl methyl cellulose (HPMC) by using the solvent-casting method. Cellulose nanofiber (CNF) was used as a compatibilizer and glycerine was used as a plasticizer. In order to find an optimum formulation, a response surface methodology and a central composite design were employed. The concentration percenta...
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