Haojie Hao
Chinese PLA General Hospital
EndocrinologyRegeneration (biology)Mesenchymal stem cellImmunologyIn vivoMacrophage polarizationInflammationInsulin resistanceStreptozotocinInsulinWound healingFibroblastAngiogenesisStem cellTransplantationCancer researchDiabetes mellitusMedicineBiologyCell biology
49Publications
23H-index
1,558Citations
Publications 48
Newest
#1Xiaoyan SongH-Index: 1
#2Xiaoya SunH-Index: 1
Last. Yiming Mu (Chinese PLA General Hospital)H-Index: 19
view all 6 authors...
This study was designed to assess whether the combination of the glucagon-like peptide-1 (GLP-1) analog exendin-4 (Ex4) and bone marrow-derived mesenchymal stem cell (BM-MSC) could enhance β-cell action in STZ-induced diabetic rats. Forty male SD rats were randomly assigned to five groups: the normal control group (Normal), diabetes group (DM), MSC-treated group (MSC), Ex4-treated group (Ex4) and MSC plus Ex4-treated group (MSC + Ex4). Body weight, blood glucose level, intraperitoneal glucose to...
Source
#1Jing Xue (Chinese PLA General Hospital)H-Index: 3
#2Yu Cheng (Chinese PLA General Hospital)H-Index: 11
Last. Yiming Mu (Chinese PLA General Hospital)H-Index: 19
view all 10 authors...
Background. Progressive β-cell dysfunction, a major characteristic of type 2 diabetes (T2D), is closely related to the infiltration of inflammatory macrophages within islets. Mesenchymal stem cells (MSCs) have been identified to alleviate β-cell dysfunction by modulating macrophage phenotype in T2D, but the restoration of β-cells by a single MSC infusion is relatively transient. Decitabine (DAC) has been reported to polarize macrophages towards the anti-inflammatory phenotype at low doses. We th...
1 CitationsSource
#1Ziying Zhu (Chinese PLA General Hospital)H-Index: 3
#2Saisong Xiao (Beijing University of Chinese Medicine)H-Index: 1
Last. Xiaobing Fu (Chinese PLA General Hospital)H-Index: 22
view all 5 authors...
: Pancreatic cancer is a highly malignant tumor with a 5-year survival rate of less than 6%, and incidence increasing year by year globally. Pancreatic cancer has a poor prognosis and a high recurrence rate, almost the same as the death rate. However, the available effective prevention and treatment measures for pancreatic cancer are still limited. The genome variation is one of the main reasons for the development of pancreatic cancer. In recent years, with the development of gene sequencing te...
2 CitationsSource
#1Jie‐Qing Gao (Capital Medical University)H-Index: 2
#2Yu Cheng (Chinese PLA General Hospital)H-Index: 11
Last. Yiming Mu (Chinese PLA General Hospital)H-Index: 9
view all 13 authors...
Mesenchymal stem cells (MSCs) have emerged as a promising therapy for type 2 diabetes (T2D). Mechanistic researches demonstrate that the anti-diabetic effect of MSCs is partially mediated by eliciting macrophages into an anti-inflammatory phenotype thus alleviating insulin resistance. However, single MSC infusion is insufficient to ameliorate sustained hyperglycemia or normalize blood glucose levels. In this study, we used decitabine (DAC), which is involved in the regulation of macrophage polar...
9 CitationsSource
#1Lingzhi Zhong (Chinese PLA General Hospital)H-Index: 3
#2Haojie Hao (Chinese PLA General Hospital)H-Index: 23
Last. Xiaobing Fu (Chinese PLA General Hospital)H-Index: 22
view all 10 authors...
BACKGROUND: Tissue contraction and the extracellular matrix deposition are part of the pathogenesis of hypertrophic scars. The transcriptional factor NFE2L2 inhibits fibroblast differentiation in idiopathic pulmonary fibrosis and promotes myofibroblast dedifferentiation. Our previous study showed that the transcription factor NFE2L2 was strongly induced on treatment with arsenic trioxide (ATO). OBJECTIVE: The present study sought to investigate the effect of ATO on myofibroblast formation to det...
9 CitationsSource
#1Yu Cheng (Chinese PLA General Hospital)H-Index: 11
Last. Haojie Hao (Chinese PLA General Hospital)H-Index: 23
view all 3 authors...
Diabetes mellitus (DM) is a major global problem, and its complications seriously threaten the human health. The failure of pancreatic islet β-cells and insulin resistance are the main mechanism of the occurrence and the development of DM, and this can be induced by immune damage and inflammatory response. The current antidiabetic drugs, which do not focus on the link of the onset of diabetes, can only relieve or alleviate the symptoms, delay the progression of the disease, but cannot cure the d...
Source
#1Yaqi Yin (Chinese PLA General Hospital)H-Index: 6
#2Haojie Hao (Chinese PLA General Hospital)H-Index: 23
Last. Yiming Mu (Chinese PLA General Hospital)H-Index: 19
view all 11 authors...
Progressive pancreatic β-cell dysfunction is recognized as a fundamental pathology of type 2 diabetes (T2D). Recently, mesenchymal stem cells (MSCs) have been identified in protection of islets function in T2D individuals. However, the underlying mechanisms remain elusive. It is widely accepted that β-cell dysfunction is closely related to improper accumulation of macrophages in the islets, and a series of reports suggest that MSCs possess great immunomodulatory properties by which they could el...
29 CitationsSource
#1Yaqi Yin (Chinese PLA General Hospital)H-Index: 6
#2Haojie Hao (Chinese PLA General Hospital)H-Index: 23
Last. Yiming Mu (Chinese PLA General Hospital)H-Index: 19
view all 10 authors...
Abstract Umbilical cord-derived mesenchymal stem cells (UC-MSCs), with both immunomodulatory and pro-regenerative properties, are promising for the treatment of type 2 diabetes mellitus (T2DM). As efficient cell therapy largely relies on appropriate homing to target tissues, knowing where and to what extent injected UC-MSCs have homed is critically important. However, bio-distribution data for UC-MSCs in T2DM subjects are extremely limited. Beneficial effects of UC-MSCs on T2DM subjects are asso...
18 CitationsSource
#1Xiaoya Sun (Chinese PLA General Hospital)H-Index: 1
#2Haojie Hao (Chinese PLA General Hospital)H-Index: 23
Last. Yiming Mu (Chinese PLA General Hospital)H-Index: 9
view all 8 authors...
Background Insulin resistance is one of the most common and important pathological features of type 2 diabetes (T2D). Recently, insulin resistance is increasingly considered to be associated with systemic chronic inflammation. Elevated levels of tumor necrosis factor (TNF)-α and interleukin (IL)-1β in blood are predictive indicators of the development of T2D. Mesenchymal stem cell (MSC)-based therapies have been proven to have potential immunomodulation and anti-inflammatory properties through t...
29 CitationsSource
#1Meirong Li (Chinese PLA General Hospital)H-Index: 10
#2Yali Zhao (Chinese PLA General Hospital)H-Index: 23
Last. Xiaobing Fu (Chinese PLA General Hospital)H-Index: 29
view all 5 authors...
Cutaneous wounding in late-gestational fetal or postnatal humans results in scar formation without any skin appendages. Early or mid- gestational skin healing in humans is characterized by the absence of scaring in a process resembling regeneration. Tremendous cellular and molecular mechanisms contribute to this distinction, and fibroblasts play critical roles in scar or scarless wound healing. This review discussed the different repair mechanisms involved in wound healing of fibroblasts at diff...
8 CitationsSource