Teruo Kawada
Kyoto University
AdipogenesisInternal medicinePeroxisomeEndocrinologyThermogenesisWhite adipose tissueReceptorAdipose tissueTumor necrosis factor alphaChemistryPeroxisome proliferator-activated receptorAdipocyteInflammationAgonistCapsaicinBrown adipose tissueLipid metabolismBiochemistryMedicineThermogeninBiologyCell biology
213Publications
64H-index
8,635Citations
Publications 211
Newest
#1Haruya Takahashi (Kyoto University)H-Index: 14
Last. Kazuo Inoue (Kyoto University)H-Index: 26
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Several isoflavonoids are well known for their ability to act as soybean phytoalexins. However, the overall effects of the soybean-Aspergillus oryzae interaction on metabolism remain largely unknown. The aim of this study is to reveal an overview of nutritive and metabolic changes in germinated and A. oryzae-elicited soybeans. The levels of individual nutrients were measured using the ustulation, ashing, Kjeldahl, and Folch methods. The levels of individual amino acids were measured using high-p...
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#1Takeshi Ara (Kyoto University)H-Index: 17
#2Nozomu SakuraiH-Index: 29
Last. Daisuke Shibata (Kyoto University)H-Index: 67
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The total number of low-molecular-weight compounds in the plant kingdom, most of which are secondary metabolites, is hypothesized to be over one million, although only a limited number of plant compounds have been characterized. Untargeted analysis, especially using mass spectrometry (MS), has been useful for understanding the plant metabolome; however, due to the limited availability of authentic compounds for MS-based identification, the identities of most of the ion peaks detected by MS remai...
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Purpose Sodium-glucose co-transporter-2 (SGLT2) inhibitors have various pleiotropic effects, including body weight reduction, and therefore have the potential to be used in various applications. However, such effects have not been fully investigated; thus, non-clinical studies using animal models are needed. In animal experiments, SGLT2 inhibitors are usually administered by oral or dietary methods. However, the detailed characteristics of these dosing methods, especially to induce their pleiotr...
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#1Kyoko Takata (Kyoto University)H-Index: 1
#2Tsuyoshi Goto (Kyoto University)H-Index: 40
Last. Noriyuki Kioka (Kyoto University)H-Index: 38
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Abstract Beige/brite adipocytes, which express high levels of uncoupling protein 1 (UCP1) to generate heat using stored triglycerides, are induced under specific stimuli such as cold exposure in inguinal white adipose tissue (iWAT). Although extracellular microenvironments such as extracellular matrix (ECM) stiffness are known to regulate cell behaviors, including cell differentiation into adipocytes, the effect on iWAT cells is unknown. In this study, we show that rigid ECM promotes the cell sp...
1 CitationsSource
#1Hiroto MinaminoH-Index: 1
#2Yoshihito FujitaH-Index: 14
Last. Nobuya InagakiH-Index: 82
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Brown adipose tissue (BAT) is a key organ that produces heat and dissipates energy, and may be clinically relevant to the treatment of obesity and diabetes. Tetrahydrobiopterin (BH4) is an essential co-factor of tyrosine hydroxylase, a rate-limiting enzyme of catecholamine biosynthesis including that of norepinephrine (NA) and nitric oxide (NO) synthase. Although both NA and NO are well-known factors in BAT differentiation, the role of BH4 in the differentiation of BAT is poorly understood. We i...
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#1Mari Iwase (Kyoto University)H-Index: 5
#2Soshi Tokiwa (Kyoto University)H-Index: 1
Last. Tsuyoshi Goto (Kyoto University)H-Index: 40
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Browning, of adipose tissue is induced by specific stimuli such as cold exposure and consists of upregulation of thermogenesis in white adipose tissue. Recently, it has emerged as an attractive target for managing obesity in humans. Here, we performed a comprehensive analysis to identify genes associated with browning in murine adipose tissue. We focused on glycerol kinase (GYK) because its mRNA expression pattern is highly correlated with that of uncoupling protein 1 (UCP1), which regulates the...
1 CitationsSource
#1Daisuke Yabe (Gidai: Gifu University)H-Index: 35
#2Jiro Nakamura (Aichi Medical University)H-Index: 41
Last. Atsushi YamauchiH-Index: 1
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Summary Background New glucose-lowering medications need to be investigated in east Asian populations, as the clinical characteristics of type 2 diabetes differ between western and east Asian patients. The PIONEER 10 study aimed to evaluate the safety and efficacy of oral semaglutide versus dulaglutide in Japanese patients with type 2 diabetes. Methods PIONEER 10 was an open-label, randomised, active-controlled, phase 3a trial done at 36 sites (clinics and university hospitals) in Japan. Patient...
29 CitationsSource
#2Eriko MisawaH-Index: 11
Last. Teruo Kawada (Kyoto University)H-Index: 64
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: The aim of this study is to investigate the mechanism of anti-obesity effects of Aloe vera gel extract (AVGE) containing Aloe sterols. Previously, we reported that oral intake of Aloe vera components has an anti-diabetic and anti-obesity effect. This study was designed to assess the role of brown adipose tissue (BAT) in the anti-obesity effect of AVGE. Six-week-old male mice were divided into three groups; STD (standard diet), HFD (60% high fat diet) and AVGE (60% high fat diet with AVGE treat...
1 CitationsSource
#1Huei-Fen Jheng (Kyoto University)H-Index: 10
#2Kanako Hayashi (Kyoto University)H-Index: 1
Last. Tsuyoshi Goto (Kyoto University)H-Index: 40
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SCOPE: Dietary soy reportedly protects from diabetic nephropathy (DN), but its active components and mechanism of action remain unknown. METHOD AND RESULT: In this study, KKAy mice model were fed three types of diet: Dietary soy isoflavones with soy protein (Soy-IP) diet, reduced isoflavones soy protein (RisoP), and oral administration of isoflavones aglycones (IsoAgc). Albuminuria and glycosuria were decreased only in Soy-IP group. The RisoP group showed reduced expansion of mesangial matrix an...
3 CitationsSource
#1Mari Iwase (Kyoto University)H-Index: 5
#2Shoko Sakai (Kyoto University)H-Index: 24
Last. Tsuyoshi Goto (Kyoto University)H-Index: 40
view all 14 authors...
ABSTRACTSpecific conditions, such as exposure to cold, can induce the production of brown-like adipocytes in white adipose tissue. These adipocytes express high levels of uncoupling protein 1 (UCP1...
3 CitationsSource