Dinesh Vyas
Michigan State University
Robotic surgeryCancerInternal medicineSurgeryNanomedicineIntensive care medicineApoptosisMaterials scienceImmunologyProteasome inhibitorSepsisColonoscopyCytokineTriple-negative breast cancerDoxorubicinCancer researchColorectal cancerMedicineBiologyCancer cell
Publications 40
#1Dinesh VyasH-Index: 12
Last. Arpita Vyas (California Northstate University College of Pharmacy)H-Index: 13
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Nowadays, with the rapid development of society and economy, people’s living standard is constantly improved, and unhealthy lifestyle is also prevalent..
#1Dinesh Vyas (MSU: Michigan State University)H-Index: 12
#2Nicolas Lopez-Hisijos (MSU: Michigan State University)H-Index: 2
Last. Lakshmi S. Chaturvedi (MSU: Michigan State University)H-Index: 11
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: Triple-Negative Breast Cancer (TNBC) has a poor prognosis due to lack of targeted therapy. Doxorubicin (DOX) has failed for multiple reasons, including development of multi-drug resistance, induction of inflammation (IL-6 secretion) and long-term toxicities. DOX is also known to have off target proteasomal activation, justifying the concept of combining it with a proteasomal inhibitor. Our study investigated the therapeutic potential of an irreversible proteasome inhibitor carfilzomib (CARF) a...
6 CitationsSource
#1Archana Balakrishnan (MSU: Michigan State University)H-Index: 4
#2Arpita VyasH-Index: 13
Last. Dinesh Vyas (MSU: Michigan State University)H-Index: 12
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Colorectal cancer accounts for a significant proportion of cancer deaths worldwide. The need to develop more chemotherapeutic agents to combat this disease is critical. Cyclin dependent kinases (CDKs), along with its binding partner cyclins, serve to control the growth of cells through the cell cycle. A new class of drugs, termed CDK inhibitors, has been studied in preclinical and now clinical trials. These inhibitors are believed to act as an anti-cancer drug by blocking CDKs to block the uncon...
12 CitationsSource
This Study has been carried out to study treatability of Fenton activated carbon catalytical oxidation for pharmaceutical waste water treatment. Pharmaceutical waste water containing high amount of organic content of non biodegradable nature , these substance are resistance to biodegradation because of low BOD/COD values. The conventional treatment may not be effective for removal of such pollutant. So, advanced oxidation processes can be a good choice for pharmaceutical waste water abetment. Of...
#1Dinesh Vyas (MSU: Michigan State University)H-Index: 12
#2Archana Balakrishnan (MSU: Michigan State University)H-Index: 4
Last. Arpita Vyas (MSU: Michigan State University)H-Index: 13
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Recently, the discussion on the implications of irreproducibility in the sciences has been brought into the spotlight. This topic has been discussed for years in the literature. A multitude of reasons have been attributed to this issue; one commonly labeled culprit is the overuse of the p value as a determinant of significance by the scientific community. Both scientists and statisticians have questioned the use of null hypothesis testing as the basis of scientific analysis. This survey of the c...
4 CitationsSource
#1Dinesh Vyas (MSU: Michigan State University)H-Index: 12
#2Sean CroninH-Index: 1
The peer review processes as outlined in the Health Care Quality Improvement Act (HCQIA) is meant ensure quality standard of care through a self-policing mechanism by the medical community. This process grants immunity for people filing a peer review, which is meant to protect whistleblowers. However, it also creates a loophole that can be used maliciously to hinder competition. This is accentuated when surgeons are integrating new technologies, such as robotic surgery, into their practice. With...
8 CitationsSource
#1Rohit AbrahamH-Index: 3
#2Dinesh Vyas (MSU: Michigan State University)H-Index: 12
Last. Arpita VyasH-Index: 13
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Trauma-related injury in fast developing countries are linked to 90% of international mortality rates, which can be greatly reduced by improvements in often non-existent or non-centralized emergency medical systems (EMS)—particularly in the pre-hospital care phase. Traditional trauma training protocols—such as Advanced Trauma Life Support (ATLS), International Trauma Life Support (ITLS), and Basic Life Support (BLS)—have failed to produce an effective pre-hospital ground force of medical first r...
1 CitationsSource