James V. Rogers
Battelle Memorial Institute
GeneHuman decontaminationNuclear chemistryPathologyGene expressionMolecular biologyVirologySporeGene expression profilingChemistryMicroarrayImmunologyVirusInflammationBacillus subtilisBacillalesYersinia pestisBacillus anthracisWound healingSulfur mustardFood sciencePersistence (computer science)ChromatographyHydrogen peroxideEndosporeMedicineMicroarray analysis techniquesBiologyMicrobiologyPharmacology
46Publications
16H-index
912Citations
Publications 45
Newest
#1Joseph P. Wood (RTP: Research Triangle Park)H-Index: 11
#2Morgan Q. S. Wendling (Battelle Memorial Institute)H-Index: 7
Last. James V. Rogers (Battelle Memorial Institute)H-Index: 16
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: A study was conducted to assess the efficacy of ozone gas in inactivating spores of both Bacillus anthracis and Bacillus subtilis inoculated onto six building materials (glass, wood, carpet, laminate, galvanized metal, and wallboard paper). Testing conditions consisted of ozone gas concentrations ranging from 7,000-12,000 parts per million (ppm), contact times from 4 to 12 h, and two relative humidity (RH) levels of 75 and 85%. Results showed that increasing the ozone concentration, contact ti...
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#1Mark R. Perry (Battelle Memorial Institute)H-Index: 5
#2Richard Warren (HHS: United States Department of Health and Human Services)H-Index: 2
Last. James V. RogersH-Index: 16
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The elimination of smallpox as an endemic disease and the obvious ethical problems with clinical challenge requires the efficacy evaluation of medical countermeasures against smallpox using the FDA Animal Rule. This approach requires the evaluation of antiviral efficacy in an animal model whose infection recapitulates the human disease sufficiently well enough to provide predictive value of countermeasure effectiveness. The narrow host range of variola virus meant that no other animal species wa...
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#1Joseph P. Wood (EPA: United States Environmental Protection Agency)H-Index: 11
#2William R. Richter (Battelle Memorial Institute)H-Index: 8
Last. James V. Rogers (Battelle Memorial Institute)H-Index: 16
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Ricin is a highly-toxic compound derived from castor plant beans. Several incidents involving contamination of residences and buildings due to ricin production or dissemination have occurred in recent years. The goal of this study was to determine whether ricin bioactivity could be attenuated in reasonable time via simple modifications of the indoor environment. Attenuation was assessed on six different materials as a function of temperature, relative humidity (RH), and contact time, using both ...
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#1William R. Richter (Battelle Memorial Institute)H-Index: 8
#2Joseph P. Wood (EPA: United States Environmental Protection Agency)H-Index: 11
Last. James V. Rogers (Battelle Memorial Institute)H-Index: 16
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Abstract The inactivation of Bacillus anthracis spores on subway and used subway railcar materials was evaluated using fogged peracetic acid/hydrogen peroxide (PAA) and hydrogen peroxide (H 2 O 2 ). A total of 21 separate decontamination tests were conducted using bacterial spores of both B. anthracis Ames ( B.a. ) and Bacillus atrophaeus ( B.g. ) inoculated onto several types of materials. Tests were conducted using commercial off-the-shelf fogging equipment filled with either PAA or H 2 O 2 to...
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#1Chris M. Cirimotich (Battelle Memorial Institute)H-Index: 10
#2Eric M. Vela (OHSU: Oregon Health & Science University)H-Index: 10
Last. James V. Rogers (Battelle Memorial Institute)H-Index: 16
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Background Chikungunya virus (CHIKV) is transmitted via mosquito bite and potentially by aerosol, causing chikungunya fever and arthritic disease in humans. There are currently no licensed vaccines or antiviral therapeutics to protect against CHIKV infection in humans. Animal models recapitulating human disease, especially for transmission by aerosol, are needed for licensure of such medical countermeasures.
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#1Jeffrey Rosen (RTI International)H-Index: 4
#2Stephen R. Porter (NCSU: North Carolina State University)H-Index: 24
Last. James V. Rogers (RTP: Research Triangle Park)H-Index: 16
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In recent years, student surveys have played an increasingly large role in educational research, policy making, and, particularly, accountability efforts. However, research on the accuracy of students’ self-reports about themselves and their education is limited to analyses of overall grade point average and ACT/SAT standardized test scores. Using a unique data set, we investigate the accuracy of students’ survey responses to questions about their course taking and grades in mathematics during h...
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#1Jennifer Garver (Battelle Memorial Institute)H-Index: 6
#2Lauren Weber (Battelle Memorial Institute)H-Index: 1
Last. James V. Rogers (Battelle Memorial Institute)H-Index: 16
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In 2007, the United States– Food and Drug Administration (FDA) issued guidance concerning animal models for testing the efficacy of medical countermeasures against variola virus (VARV), the etiologic agent for smallpox. Ectromelia virus (ECTV) is naturally-occurring and responsible for severe mortality and morbidity as a result of mousepox disease in the murine model, displaying similarities to variola infection in humans. Due to the increased need of acceptable surrogate animal models for poxvi...
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#1James V. Rogers (Battelle Memorial Institute)H-Index: 16
#2Andrew T. Lastivka (Battelle Memorial Institute)H-Index: 1
Last. William R. Richter (Battelle Memorial Institute)H-Index: 8
view all 3 authors...
This study evaluated the persistence of Burkholderia mallei China 7 deposited on glass, Hypalon rubber glove, and stainless steel, as well as inactivation with vaporous hydrogen peroxide fumigation...
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In resource-limited nations, enhancing the shelf-life and stability of critical reagents and consumables is desired. This study evaluated the shelf-life of bacteriological plates in vacuum-sealed nylon/polyethylene packaging flushed with nitrogen (FlatPacks®). Tryptic soy agar (TSA) FlatPacks held at room temperature for 24 months did not change in appearance or texture and supported bacterial growth similar to Day 0 concentrations. In contrast, TSA plates from a different supplier (Vendor A) de...
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#3Thomas J. Kelly (Battelle Memorial Institute)H-Index: 89
There is a lack of data for how the viability of biological agents may degrade over time in different environments. In this study, experiments were conducted to determine the persistence of Bacillus anthracis and Bacillus subtilis spores on outdoor materials with and without exposure to simulated sunlight, using ultraviolet (UV)-A/B radiation. Spores were inoculated onto glass, wood, concrete, and topsoil and recovered after periods of 2, 14, 28, and 56 days. Recovery and inactivation kinetics f...
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