Huiyuan Gao
Shenyang Pharmaceutical University
TriterpenoidBiological activityCircular dichroismOrganic chemistryChemistryGlycosideTwo-dimensional nuclear magnetic resonance spectroscopySesquiterpeneCaesalpiniaLactoneLanostaneMethanolAnti-inflammatoryEthyl acetateCaesalpinia minaxAbies sachalinensisSpectral analysisTerpeneBiochemistryTraditional medicineBotanyStereochemistry
59Publications
12H-index
524Citations
Publications 59
Newest
#1Miao Wang (SPU: Shenyang Pharmaceutical University)H-Index: 9
#2Xinxin Zhang (SPU: Shenyang Pharmaceutical University)H-Index: 3
Last. Huiyuan Gao (SPU: Shenyang Pharmaceutical University)H-Index: 12
view all 6 authors...
Abstract null null The first investigation of phytochemistry on the seed kernels of Caesalpinia sinensis led to the isolation and characterization of six new compounds including three tricyclic-type cassane diterpenoids (1‐–3) and three norcassane-type diterpenoids (4–6), together with three know compounds (7–9). Compounds 1–9 represented the first discovery of cassane-type diterpenoids from C. sinensis. Their structures were elucidated by a combination of spectroscopic analysis, single-crystal ...
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#1Miao Wang (SPU: Shenyang Pharmaceutical University)H-Index: 9
#2Siyu Yu (SPU: Shenyang Pharmaceutical University)
Last. Huiyuan Gao (SPU: Shenyang Pharmaceutical University)H-Index: 12
view all 7 authors...
Eighteen cassane diterpenoids, including five new lactam-type (4-8), 12 new lactone-type (1-3 and 9-17), and one known compound (18), were isolated from Caesalpinia sinensis. To our knowledge, this is the first study on the seed kernels of C. sinensis, and cassane derivatives were discovered in this plant for the first time. Their structures including absolute configurations were established by extensive spectroscopic methods complemented with single-crystal X-ray diffraction analyses and ECD ca...
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#1Ting LiuH-Index: 1
Last. Huiyuan GaoH-Index: 12
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#1Miao Wang (SPU: Shenyang Pharmaceutical University)H-Index: 9
#2Tianliang Zhu (SPU: Shenyang Pharmaceutical University)
Last. Huiyuan Gao (SPU: Shenyang Pharmaceutical University)H-Index: 12
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The first investigation of chemical composition in seed kernels of Caesalpinia cucullata Roxb. resulted in the separation of four new cassane diterpenes, including three furanoditerpenes (1, 2 and 4) and one tricyclic type (3). It was the first found cassane diterpenoids from this plant. Their gross structures were elucidated by means of comprehensive spectroscopic analysis (UV, IR, NMR, HRESIMS) as well as electronic circular dichroism (ECD) calculation. The compound 1 possess a rare isomerized...
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#1Shizhou Qi (SPU: Shenyang Pharmaceutical University)H-Index: 4
#2Xinxin Zhang (SPU: Shenyang Pharmaceutical University)H-Index: 3
Last. Huiyuan Gao (SPU: Shenyang Pharmaceutical University)H-Index: 12
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Abstract Our present and previous phytochemical investigations on Leptopus lolonum have resulted in the isolation of almost 30 phenylpropanoid-conjugated pentacyclic triterpenoids (PCPTs). During the continuous study on PCPTs, this kind of triterpenoid ester is considered as a natural product with low toxicity because of it’s widely distribution in natural plants and edible fruits including kiwi fruit, durian, jujube, pawpaw, apple and pear. In the present work, we report the isolation, structur...
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#1Liping LongH-Index: 3
Last. Huiyuan GaoH-Index: 12
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#1Ting Liu (SPU: Shenyang Pharmaceutical University)H-Index: 1
#2Xiang Li (SPU: Shenyang Pharmaceutical University)
Last. Huiyuan Gao (SPU: Shenyang Pharmaceutical University)H-Index: 12
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In this study, phytochemical investigation on the chloroform soluble fraction of seed kernels of Caesalpinia bonduc led to the isolation of two new cassane-type diterpenoids, norcaesalpinin Q (1) a...
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#1Miao Wang (SPU: Shenyang Pharmaceutical University)H-Index: 9
#2Yiren Yang (SPU: Shenyang Pharmaceutical University)H-Index: 4
Last. Huiyuan Gao (SPU: Shenyang Pharmaceutical University)H-Index: 12
view all 8 authors...
2 CitationsSource
#1Shizhou Qi (SPU: Shenyang Pharmaceutical University)H-Index: 4
#2Ting Liu (SPU: Shenyang Pharmaceutical University)H-Index: 1
Last. Huiyuan Gao (SPU: Shenyang Pharmaceutical University)H-Index: 12
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Abstract Most of Euphorbiaceae plants are considered as folk medicinal plants because of their various pharmacological effects. However, there are eight Leptopus genus plants which belong to Euphorbiaceae have never be investigated. Thus, four Leptopus genus plants were collected to study their chemical constituents and pharmacological activities. In the present work, the cytotoxicities of the extracts of four Leptopus genus plants were evaluated before phytochemical experiments. And nine new ph...
1 CitationsSource
#1Qiang Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 1
#2Yunpeng Bai (DICP: Dalian Institute of Chemical Physics)H-Index: 1
Last. Xiaozhe Zhang (DICP: Dalian Institute of Chemical Physics)H-Index: 16
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Abstract Background Peptides have diverse and important physiological roles in plants and are ideal markers for species identification. It is unclear whether there are specific peptides in Panax quinquefolius L. (PQ). The aims of this study were to identify Quinetides, a series of diverse posttranslational modified native peptides of the ribonuclease-like storage protein (ginseng major protein), from PQ to explore novel peptide markers and develop a new method to distinguish PQ from Panax ginsen...
1 CitationsSource