Huiyuan Gao
Shenyang Pharmaceutical University
TriterpenoidBiological activityCircular dichroismOrganic chemistryChemistryGlycosideTwo-dimensional nuclear magnetic resonance spectroscopySesquiterpeneCaesalpiniaLanostaneMethanolEthyl acetateCaesalpinia minaxAbies sachalinensisSpectral analysisTerpeneBiochemistryTraditional medicineBotanyStereochemistryBiology
59Publications
13H-index
542Citations
Publications 53
Newest
#1Miao Wang (SPU: Shenyang Pharmaceutical University)H-Index: 9
#2Tianliang Zhu (SPU: Shenyang Pharmaceutical University)
Last. Huiyuan Gao (SPU: Shenyang Pharmaceutical University)H-Index: 13
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The first investigation of chemical composition in seed kernels of Caesalpinia cucullata Roxb. resulted in the separation of four new cassane diterpenes, including three furanoditerpenes (1, 2 and 4) and one tricyclic type (3). It was the first found cassane diterpenoids from this plant. Their gross structures were elucidated by means of comprehensive spectroscopic analysis (UV, IR, NMR, HRESIMS) as well as electronic circular dichroism (ECD) calculation. The compound 1 possess a rare isomerized...
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#1Shizhou Qi (SPU: Shenyang Pharmaceutical University)H-Index: 3
#2Xinxin Zhang (SPU: Shenyang Pharmaceutical University)H-Index: 3
Last. Huiyuan Gao (SPU: Shenyang Pharmaceutical University)H-Index: 13
view all 9 authors...
Abstract Our present and previous phytochemical investigations on Leptopus lolonum have resulted in the isolation of almost 30 phenylpropanoid-conjugated pentacyclic triterpenoids (PCPTs). During the continuous study on PCPTs, this kind of triterpenoid ester is considered as a natural product with low toxicity because of it’s widely distribution in natural plants and edible fruits including kiwi fruit, durian, jujube, pawpaw, apple and pear. In the present work, we report the isolation, structur...
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#1Ting Liu (SPU: Shenyang Pharmaceutical University)H-Index: 1
#2Xiang Li (SPU: Shenyang Pharmaceutical University)
Last. Huiyuan Gao (SPU: Shenyang Pharmaceutical University)H-Index: 13
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In this study, phytochemical investigation on the chloroform soluble fraction of seed kernels of Caesalpinia bonduc led to the isolation of two new cassane-type diterpenoids, norcaesalpinin Q (1) a...
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#1Miao Wang (SPU: Shenyang Pharmaceutical University)H-Index: 9
#2Yiren Yang (SPU: Shenyang Pharmaceutical University)H-Index: 4
Last. Huiyuan Gao (SPU: Shenyang Pharmaceutical University)H-Index: 13
view all 8 authors...
1 CitationsSource
#1Shizhou Qi (SPU: Shenyang Pharmaceutical University)H-Index: 3
#2Ting Liu (SPU: Shenyang Pharmaceutical University)H-Index: 1
Last. Huiyuan Gao (SPU: Shenyang Pharmaceutical University)H-Index: 13
view all 10 authors...
Abstract Most of Euphorbiaceae plants are considered as folk medicinal plants because of their various pharmacological effects. However, there are eight Leptopus genus plants which belong to Euphorbiaceae have never be investigated. Thus, four Leptopus genus plants were collected to study their chemical constituents and pharmacological activities. In the present work, the cytotoxicities of the extracts of four Leptopus genus plants were evaluated before phytochemical experiments. And nine new ph...
1 CitationsSource
#1Liping LongH-Index: 3
Last. Huiyuan GaoH-Index: 13
view all 9 authors...
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#1Shizhou Qi (SPU: Shenyang Pharmaceutical University)H-Index: 3
#2Yiren Yang (SPU: Shenyang Pharmaceutical University)H-Index: 4
Last. Huiyuan Gao (SPU: Shenyang Pharmaceutical University)H-Index: 13
view all 5 authors...
AbstractSaussurea involucrata, known for the abundant bioactive components, is a precious traditional Chinese medicine. In this study, a novel guaiane sesquiterpenoid glycoside named (1R, 5R, 6R, 7...
4 CitationsSource
#1Liping Long (SPU: Shenyang Pharmaceutical University)H-Index: 3
#2Lushan Wang (SPU: Shenyang Pharmaceutical University)H-Index: 1
Last. Huiyuan Gao (SPU: Shenyang Pharmaceutical University)H-Index: 13
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AbstractSix sesquiterpenoids and four lignans (1–10) were isolated from the n-BuOH extract of the rhizomes of Atractylodes lancea. Among them, the new sesquiterpenoid glycoside named (4 R, 5S, 7R)-hinesolone-11-O-β-ᴅ-glucopyranoside (1), along with three known compounds (2–4) were first obtained from this genus. All the isolates were elucidated by spectroscopic analyses and chemical methods, and the absolute configurations were assigned by electronic circular dichroism spectroscopy technique. In...
5 CitationsSource
#1Xiaowen Jiang (SPU: Shenyang Pharmaceutical University)H-Index: 7
#2Wenwu Liu (SPU: Shenyang Pharmaceutical University)H-Index: 4
Last. Qingchun Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 13
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Abstract Ethnopharmacological relevance Alzheimer's disease (AD) is a frequently occurring disease of the elderly, and “deficiency” is the root of AD. Most famous experts of traditional Chinese medicine believe that the disease is based on deficiency, and the deficiency of kidney essence is the basis. Notopterygium incisum (Qiang huo) is specialized in bladder and liver and kidney. Treatment of liver and kidney deficiency, language difficulty, mental coma. Qiang huo yu feng tang has been used to...
5 CitationsSource
#1Ting Liu (SPU: Shenyang Pharmaceutical University)H-Index: 1
#2Miao Wang (SPU: Shenyang Pharmaceutical University)H-Index: 9
Last. Huiyuan Gao (SPU: Shenyang Pharmaceutical University)H-Index: 13
view all 9 authors...
Abstract In this paper, chemical investigation on the chloroform soluble fraction of seed kernels of Caesalpinia bonduc resulted in the isolation of five new cassane diterpenoids: norcaesalpinin O (1), norcaesalpinin P (2), caesalpinin MQ (3), caesall O/P (4/5) and seven known compounds (6-12). Compounds structures were elucidated by 1H NMR, 13C NMR, 2D NMR, HR-MS and ECD (electronic circular dichroism) spectral analysis. The characters for new compounds with the presence of an aromatized C ring...
2 CitationsSource