Thilo Hackert
University Hospital Heidelberg
CancerInternal medicineRadiologySurgeryPathologyOncologyResectionRandomized controlled trialPancreatitisPancreatectomyPancreasAbdominal surgeryPancreatic cancerPancreatic fistulaPerioperativeCancer researchGeneral surgeryMedicineBiologyGastroenterology
Publications 484
#1Lukas F. Liesenfeld (University Hospital Heidelberg)H-Index: 1
#2Thomas Schmidt (University Hospital Heidelberg)H-Index: 31
Last. Anja Schaible (University Hospital Heidelberg)H-Index: 8
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Abstract null null Background null Anastomotic leakage (AL) is a common and severe complication after upper gastrointestinal (UGI) surgery. Although evidence is scarce, endoscopic deployed self-expanding metal stents (SEMS) are well-established for the management of AL in UGI surgery. The present study aimed to evaluate the feasibility, effectiveness, and safety of SEMS in terms of success, mortality, and morbidity in patients with AL after UGI cancer surgery. null null null Materials and Method...
#1Susanne Roth (University Hospital Heidelberg)H-Index: 3
#2Thilo Hackert (University Hospital Heidelberg)H-Index: 57
Pancreatic cancer is a very aggressive malignant disease with an extremely poor prognosis; however, the survival of patients at all tumor stages is highly variable. Standard therapies, which are based predominantly on the TNM classification, patient's general condition and comorbidities, are highly variable in their effectiveness. In recent years, new technologies with multi-omics tumor characterizations have revealed the molecular heterogeneity of pancreatic cancer; however, in routine clinical...
#1Ulrike Heger (Heidelberg University)H-Index: 15
#2Claudia Mack (Heidelberg University)
Last. Thilo Hackert (Heidelberg University)H-Index: 57
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Abstract null null Background/objectives null Irreversible electroporation (IRE) is an emerging treatment for locally advanced pancreatic cancer (LAPC) which in some cohorts has been associated with severe complications. Additionally, re-resection of isolated local recurrence (ILR) after pancreatic ductal adenocarcinoma (PDAC) can improve survival. We investigated safety, feasibility and oncologic outcomes in the first report on open IRE for unresectable ILR of PDAC in a staged surgical approach...
#1Christoph Springfeld (University Hospital Heidelberg)H-Index: 23
#2Peter BaileyH-Index: 39
Last. John P. Neoptolemos (University Hospital Heidelberg)H-Index: 125
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#1Matthias Lang (University Hospital Heidelberg)H-Index: 2
#2Thilo Hackert (University Hospital Heidelberg)H-Index: 57
Last. Chrysanthi Anamaterou (University Hospital Heidelberg)
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Purpose null Neuroendocrine neoplasia (NEN) of the thymus is a very rare entity with poor prognosis. No study based standard treatment is established. Usually therapy protocols for bronchopulmonary carcinoids are used. So far no data exist on the effect of mTOR-inhibitors. We describe our long term experience with everolimus and give a thorough review of the therapeutic strategies used so far. null Patients and methods null 4 patients (mean age 46 years, range 37-55) with progressing thymic NEN ...
#1Anna-Katharina König (University Hospital Heidelberg)H-Index: 2
#2Hélène Gros (University Hospital Heidelberg)
Last. Oliver Strobel (University Hospital Heidelberg)H-Index: 50
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BACKGROUND With changes in T and N categories the 8th edition of the AJCC/UICC TNM staging system for pancreatic cancer resulted in improved prognostic staging, but inconsistencies were observed with specific stage groups. Tumour grading remains disregarded in prognostic staging. We aimed to validate the current staging system and to investigate the possibility of further optimization by integration of grading. METHODS 1946 patients undergoing upfront surgical resection for pancreatic adenocarci...
#1Eva-Maria Kamionka (Heidelberg University)
#2Baifeng Qian (Heidelberg University)H-Index: 1
Last. Eduard Ryschich (Heidelberg University)H-Index: 26
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The dominant intrastromal T-cell infiltration in pancreatic cancer is mainly caused by the contact guidance through the excessive desmoplastic reaction and could represent one of the obstacles to an effective immune response in this tumor type. This study analyzed the collagen organization in normal and malignant pancreatic tissues as well as its influence on T-cell distribution in pancreatic cancer. Human pancreatic tissue was analyzed using immunofluorescence staining and multiphoton and SHG m...
Last. Mengmeng Du (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 16
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Background null Epidemiological studies have suggested positive associations for iron and red meat intake with risk of pancreatic ductal adenocarcinoma (PDAC). Inherited pathogenic variants in genes involved in the hepcidin-regulating iron metabolism pathway are known to cause iron overload and hemochromatosis. null Objectives null The objective of this study was to determine whether common genetic variation in the hepcidin-regulating iron metabolism pathway is associated with PDAC. null Methods...
#1John P. NeoptolemosH-Index: 125
#2Paula GhanehH-Index: 62
Last. Thilo HackertH-Index: 57
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#1Benedict Kinny-Köster (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 3
#2Joseph R. Habib (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 6
Last. Jin He (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 40
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Purpose null The resection of retropancreatic nerve plexuses for pancreatic head cancer became standard of care during open pancreatoduodenectomy to minimize local recurrences. Since more surgical centers are progressing on the learning curve, robotically-assisted pancreatoduodenectomy is now increasingly performed with decreasing anatomic exclusion criteria. To achieve comparable and favorable oncologic outcomes, advanced surgical techniques should be transferred and implemented when performing...