Cynthia M. Magro
Cornell University
SurgeryPathologyDermatologyImmunologyImmunohistochemistryLupus erythematosusBiopsyVasculitisT cellConnective tissue diseaseMelanomaLungMycosis fungoidesDermatomyositisDiseaseLymphomaSkin biopsyCancer researchMedicineBiology
467Publications
58H-index
12.3kCitations
Publications 470
Newest
#1Gerard J. Nuovo (OSU: Ohio State University)H-Index: 83
#2Cynthia M. Magro (Cornell University)H-Index: 58
Last. Esmerina Tili (OSU: Ohio State University)H-Index: 24
view all 10 authors...
Neurologic complications of symptomatic COVID-19 are common. Brain tissues from 13 autopsies of people who died of COVID-19 were examined. Cultured endothelial and neuronal cells were incubated with and wild type mice were injected IV with different spike subunits. In situ analyses were used to detect SARS-CoV-2 proteins and the host response. In 13/13 brains from fatal COVID-19, pseudovirions (spike, envelope, and membrane proteins without viral RNA) were present in the endothelia of microvesse...
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#1Cynthia M. Magro (Cornell University)H-Index: 58
#2Justin Mulvey (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 1
Last. Gerard J. Nuovo (OSU: Ohio State University)H-Index: 83
view all 8 authors...
The objective of this study was to elucidate the pathophysiology that underlies severe COVID-19 by assessing the histopathology and the in situ detection of infectious SARS-CoV-2 and viral capsid proteins along with the cellular target(s) and host response from twelve autopsies. There were three key findings: 1) high copy infectious virus was limited mostly to the alveolar macrophages and endothelial cells of the septal capillaries; 2) viral spike protein without viral RNA localized to ACE2+ end...
2 CitationsSource
#1Kimberly Showalter (HSS: Hospital for Special Surgery)H-Index: 2
#2Robert Spiera (HSS: Hospital for Special Surgery)H-Index: 41
Last. Jessica K. Gordon (HSS: Hospital for Special Surgery)H-Index: 19
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Objective We sought to determine histologic and gene expression features of clinical improvement in early diffuse cutaneous systemic sclerosis (dcSSc; scleroderma). Methods Fifty-eight forearm biopsies were evaluated from 26 individuals with dcSSc in two clinical trials. Histologic/immunophenotypic assessments of global severity, alpha-smooth muscle actin (aSMA), CD34, collagen, inflammatory infiltrate, follicles and thickness were compared with gene expression and clinical data. Support vector ...
3 CitationsSource
#1Christopher R. Showers (Cornell University)
#2Gerard J. Nuovo (OSU: Ohio State University)H-Index: 83
Last. Cynthia M. Magro (Cornell University)H-Index: 58
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We report a patient with severe Covid-19-associated coagulopathy and type 2 diabetes mellitus who tested positive for antiphospholipid antibodies (aPL). Analysis of skin specimens suggested direct SARS-CoV-2 viral-induced and complement-mediated vascular injury and thrombosis, consistent with prior reports. Serial aPL testing demonstrated high levels of anticardiolipin antibodies (aCL) that declined to insignificant levels over a period of 5 weeks. SARS-CoV-2 RNA was detected in nasopharyngeal s...
3 CitationsSource
#1Cynthia M. Magro (Cornell University)H-Index: 58
#2J. Justin Mulvey (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 10
Last. Gerard J. Nuovo (OSU: Ohio State University)H-Index: 83
view all 8 authors...
Abstract Background There are two distinctive acral manifestations of COVID-19 embodying disparate clinical phenotypes: one is perniosis occurring in mildly symptomatic patients, typically children;the second is the thrombotic retiform purpura of critically ill COVID19 adults Materials and Methods We compare light-microscopic, phenotypic, cytokine, and SARS-CoV-2 protein and RNA profiles in COVID-19-associated perniosis of mildly symptomatic or asymptomatic patients with the thrombotic retiform ...
19 CitationsSource
#1Cynthia M. Magro (Cornell University)H-Index: 58
#2J. Justin Mulvey (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 10
Last. Gerard J. Nuovo (OSU: Ohio State University)H-Index: 83
view all 9 authors...
The purpose of this study was to examine the deltoid skin biopsy in twenty-three patients with coronavirus disease 2019 (COVID-19), most severely ill, for vascular complement deposition and correlate this with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral RNA and protein localization and ACE2 expression. Deltoid skin microvascular complement screening has been applied to patients with various systemic complement-mediated microvascular syndromes, best exemplified by atypical ...
3 CitationsSource
#1Victoria A. Perez (Columbia University)
#2Sameera Husain (Columbia University)H-Index: 10
Last. Laura E. Levin (Columbia University)H-Index: 4
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#1Kimberly Showalter (HSS: Hospital for Special Surgery)H-Index: 2
#2Cynthia M. Magro (Cornell University)H-Index: 58
Last. Jessica K. Gordon (HSS: Hospital for Special Surgery)H-Index: 19
view all 6 authors...
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#2Rochelle CastilloH-Index: 3
Last. H. Michael BelmontH-Index: 19
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#1Gerard J. NuovoH-Index: 83
#2Esmerina Tili (OSU: Ohio State University)H-Index: 24
Last. Cynthia M. MagroH-Index: 58
view all 6 authors...
Abstract The vaccine BCG has been reported to offer protection against SARS-CoV-2 infection. It has been hypothesized this is based on nonspecific enhancement of innate immunity. This study addressed whether there is strong homology between a SARS-CoV-2 capsid protein and a Mycobacterium bovis protein that would allow for stronger, more specific immune protection. The study also showed the utility of immunohistochemistry in the diagnostic pathology laboratory for elucidating this information. Im...
7 CitationsSource
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