David A. Griffith
Pfizer
PharmacokineticsInternal medicineEndocrinologyProduct (category theory)BusinessCannabinoid receptorMultinational corporationEconomicsMarketingReceptorOrganic chemistryChemistryStructure–activity relationshipNew product developmentIn vivoBicyclic moleculePeptideAcetyl-CoA carboxylaseContext (language use)CannabinoidGlycalIndustrial organizationBiochemistryStereochemistryMedicinePharmacology
230Publications
73H-index
11.1kCitations
Publications 113
Newest
Agonism of the glucagon-like peptide-1 receptor (GLP-1R) results in glycemic lowering and body weight loss and is a therapeutic strategy to treat type 2 diabetes (T2D) and obesity. We developed danuglipron (PF-06882961), an oral small-molecule GLP-1R agonist and found it had comparable efficacy to injectable peptidic GLP-1R agonists in a humanized mouse model. We then completed a placebo-controlled, randomized, double-blind, multiple ascending-dose phase 1 study ( null null null null null null n...
1 CitationsSource
#1Heather Eng (Pfizer)H-Index: 15
#2Yi-an Bi (Pfizer)H-Index: 20
Last. Manthena V.S. Varma (Pfizer)H-Index: 38
view all 11 authors...
It is generally presumed that uptake transport mechanisms are of limited significance in hepatic clearance for lipophilic or high passive permeability drugs. In this study, we evaluated the mechanistic role of the hepato-selective organic anion transporting polypeptides (OATP1B1/1B3) in the pharmacokinetics of compounds representing large lipophilic acid space. Intravenous pharmacokinetics of 16 compounds, with molecular weight ~400-730 Da, logP ~3.5-8 and acid pKa 6.5), which generally showed h...
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#1David A. Griffith (Pfizer)H-Index: 73
#2David J. Edmonds (Pfizer)H-Index: 25
Last. David A. Tess (Pfizer)H-Index: 17
view all 24 authors...
Abstract Peptide agonists of the glucagon-like peptide-1 receptor (GLP-1R) have revolutionized diabetes therapy, but their use has been limited by the requirement for injection. Here we describe the first effective, orally bioavailable small molecule GLP-1R agonists. A sensitized high-throughput screen identified a series of small molecule GLP-1R agonists that were optimized to promote endogenous GLP-1R signaling with nM potency. These small molecule agonists increased insulin levels in primates...
3 CitationsSource
#1David A. TessH-Index: 17
#2Heather EngH-Index: 15
Last. Manthena V.S. VarmaH-Index: 38
view all 7 authors...
Prospective predictions of human hepatic clearance for anionic/zwitterionic compounds, which are oftentimes subjected to transporter-mediated uptake, are challenging in drug discovery. We evaluated the utility of preclinical species, rats and cynomolgus monkeys [nonhuman primates (NHPs)], to predict the human hepatic clearance using a diverse set of acidic/zwitterionic drugs. Preclinical clearance data were generated following intravenous dosing in rats/NHPs and compared to the human clearance d...
1 CitationsSource
#1Kim HuardH-Index: 12
#2Aaron C. Smith (Pfizer)H-Index: 12
Last. Xiaojing Helen YangH-Index: 1
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Preclinical and clinical data suggest that acetyl-CoA carboxylase (ACC) inhibitors have the potential to rebalance disordered lipid metabolism leading to improvements in non-alcoholic steatohepatit...
1 CitationsSource
#1Xu ZhengH-Index: 5
#2David A. GriffithH-Index: 44
Last. Uri BenolielH-Index: 3
view all 4 authors...
Supplemental Material, jm.18.0413-File003 for Effects of Contract Ambiguity in Interorganizational Governance by Xu (Vivian) Zheng, David A. Griffith, Ling Ge and Uri Benoliel in Journal of Marketing
Source
#1William P. Esler (Pfizer)H-Index: 10
#2Gregory J. Tesz (Pfizer)H-Index: 5
Last. Gabriele E. Sonnenberg (Pfizer)H-Index: 4
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Sebum plays important physiological roles in human skin. Excess sebum production contributes to the pathogenesis of acne vulgaris, and suppression of sebum production reduces acne incidence and severity. We demonstrate that sebum production in humans depends on local flux through the de novo lipogenesis (DNL) pathway within the sebocyte. About 80 to 85% of sebum palmitate (16:0) and sapienate (16:1n10) were derived from DNL, based on stable isotope labeling, much higher than the contribution of ...
15 CitationsSource
#1Xu ZhengH-Index: 5
#2Aric Rindfleisch (UIUC: University of Illinois at Urbana–Champaign)H-Index: 33
Last. Kersi D. Antia (UWO: University of Western Ontario)H-Index: 14
view all 4 authors...
Source
#1Paola Cillo (Bocconi University)H-Index: 6
#2David A. Griffith (MSU: Michigan State University)H-Index: 73
Last. Gaia Rubera (Bocconi University)H-Index: 18
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The marketing-finance interface literature has largely investigated the direct link between innovativeness and stock returns. In this paper, we move a step further investigating two key unanswered questions: How and under what conditions is innovativeness associated with stock returns? Answering these questions is important for marketing managers who have to defend innovation investments to board members and time the introductions of new products. To answer these questions, we investigate large ...