Jin Sook Kim
Inha University
Internal medicineEndocrinologyGlycationMolecular biologyCell adhesion moleculeChemistryApoptosisIn vitroIn vivoOxidative stressAldose reductaseUmbilical veinStreptozotocinDiabetic retinopathyDiabetic nephropathyRetinalBiochemistryDiabetes mellitusTraditional medicineMedicineCell adhesionBiologyPharmacology
245Publications
35H-index
3,898Citations
Publications 221
Newest
#1Jung Hyun KimH-Index: 60
#2Chan-Sik KimH-Index: 20
Last. Jin Sook KimH-Index: 35
view all 6 authors...
This study investigated the effects of the n-BuOH soluble fraction of Polygoni Cuspidati 80% ethanol extract (POCU1b) on high-fat diet (HFD)-induced obesity, non-alcoholic fatty liver (NAFL), and insulin resistance (IR) to find a safe and more effective agent. HPLC profiling of POCU1b identified seven marker compounds. POCU1b increased glycerol release, cyclic adenosine monophosphate (cAMP) level, and inhibited phosphodiesterase (PDE) activity. Seven weeks of POCU1b treatment decreased body weig...
Source
#1Young Sook KimH-Index: 18
#1Young S. KimH-Index: 91
Last. Jin Sook KimH-Index: 35
view all 8 authors...
Increased formation of advanced glycation end products (AGEs) plays an important role in the development of diabetic retinopathy (DR) via blood-retinal barrier (BRB) dysfunction, and reduction of AGEs has been suggested as a therapeutic target for DR. In this study, we examined whether CPA4-1, a herbal combination of Cinnamomi Ramulus and Paeoniae Radix, inhibits AGE formation. CPA4-1 and fenofibrate were tested to ameliorate changes in retinal capillaries and retinal occludin expression in db/d...
2 CitationsSource
#1Bo-Jeong PyunH-Index: 3
#2Young S. KimH-Index: 91
Last. Jin Sook KimH-Index: 35
view all 6 authors...
The accumulation and formation of advanced glycation end products (AGEs) are related to diabetes and age-related disease. Osteomeles schwerinae C. K. Schneid. (Rosaceae, OSSC) is used traditionally for the treatment of various diseases in Asia. Previous studies have shown that OSSC elicits preventive effects in an in vivo model of diabetes. This study was to evaluate the antiapoptotic effects of dried leaves and twigs of OSSC extract and its major compounds in ARPE-19 cells—spontaneously arising...
2 CitationsSource
#1Eunsoo Jung (SNU: Seoul National University)H-Index: 9
#2Wookwon Jung (CBNU: Chonbuk National University)H-Index: 2
Last. Junghyun Kim (CBNU: Chonbuk National University)H-Index: 7
view all 6 authors...
EGHB010 is a standardized herbal formula of the rhizome mixture of Paeonia lactiflora Pallas and Glycyrrhiza uralensis Fisch. Neovascularization in the retina is a common pathophysiology of diabetic retinal microvasculopathy and exudative macular degeneration. In this study, we evaluated the inhibitory effects of EGHB010 on abnormal retinal angiogenesis in a hyperoxia-induced neovascular retinopathy model. Vascular endothelial growth factor (VEGF)-mediated vascular tube formation was assayed in ...
PURPOSE: Here, we aimed to determine the effect of Polygonum cuspidatum stem extract (PSE) on exorbital lacrimal gland-excised rat models and hyperosmotic stress-stimulated human conjunctival cells (HCCs). METHODS: Seven week old male Wistar rats were divided into six groups. Only the rats in the control group (NOR, n=5) did not undergo surgery. Three days after the surgery, the exorbital lacrimal gland-excised rats were randomly allocated to five groups: (1) vehicle-treated dry-eyed rats (DED, ...
2 CitationsSource
#1Bongkyun ParkH-Index: 5
#2Kyuhyung JoH-Index: 12
Last. Chan-Sik KimH-Index: 20
view all 6 authors...
Polydatin (also named pieceid, (E)-piceid, (E)-polydatin, trans-polydatin, or 3,5,4’-trihydroxystilbene-3-b-D-glucoside) is a monocrystalline compound isolated from the root and rhizome of Polygonum cuspidatum Sieb. et Zucc. (Polygonaceae). A previous study showed that polydatin has antioxidant and anti-inflammatory effects. However, the effect of polydatin in dry eye disease (DED) has not been elucidated. DED rat models were induced by exorbital lacrimal gland-excision. In vivo, the present stu...
14 CitationsSource
Background. Pueraria lobata is used in traditional Asian medicine to treat cardiovascular diseases, diarrhea, diabetes mellitus, and diabetic complications such as diabetic retinopathy. Oxidative stress in retinal pigment epithelial cells is implicated in the pathogenesis of retinopathy and age-related macular degeneration (AMD). Here, we evaluated whether the P. lobata extract can prevent cell death and decrease membrane permeability in oxidative stress-induced human retinal pigment epithelial ...
1 CitationsSource
#1Tae Gu LeeH-Index: 5
#2Soo-Wang HyunH-Index: 5
Last. Chan-Sik KimH-Index: 20
view all 7 authors...
Source
#1Junghyun Kim (CBNU: Chonbuk National University)H-Index: 7
#2Soo-Wang HyunH-Index: 5
Last. Chan-Sik KimH-Index: 20
view all 7 authors...
The Aster koraiensis extract (ASKO) is a newly developed dietary herbal supplement. In this study, the potent blood glucose-lowering activity of ASKO in vitro and in vivo was investigated. In an in vitro glucose uptake assay, ASKO was found to enhance glucose transport in 3T3-L1 adipocytes. Oral administration of ASKO significantly reduced glucose levels in normoglycemic mice during oral glucose tolerance tests (OGTTs). In a long-term efficacy study, 4 weeks of oral ASKO treatment significantly ...
2 CitationsSource
#1Bongkyun ParkH-Index: 6
#2Tae Gu LeeH-Index: 5
Last. Chan-Sik KimH-Index: 20
view all 7 authors...
Source