Thomas U. Ahearn
Harvard University
ErgCancerVitamin D and neurologyInternal medicineEndocrinologyOncologyOdds ratioProspective cohort studyImmunohistochemistryProstateColorectal adenomaVitaminPTENTMPRSS2DiseaseLower riskProstate cancerCalciumBreast cancerMedicineBiologyGastroenterology
Publications 63
#1Xiaoliang WangH-Index: 5
Last. Sara LindströmH-Index: 62
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Background Tumor-associated stroma is comprised of fibroblasts, tumor infiltrating lymphocytes (TILs), macrophages, endothelial, and other cells, that interactively influence tumor progression through inflammation and wound repair. Although gene expression signatures reflecting wound repair predict breast cancer survival, it is unclear whether combined density of tumor-associated stromal cells, a morphological proxy for inflammation and wound repair signatures on routine hematoxylin and eosin (H...
#1Amber N Wilcox (UNC: University of North Carolina at Chapel Hill)H-Index: 2
#1Amber N. Hurson (UNC: University of North Carolina at Chapel Hill)H-Index: 2
Last. Julie E. BuringH-Index: 197
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Background Rigorous evaluation of the calibration and discrimination of breast-cancer risk-prediction models in prospective cohorts is critical for applications under clinical guidelines. We comprehensively evaluated an integrated model incorporating classical risk factors and a 313-variant polygenic risk score (PRS) to predict breast-cancer risk. Methods Fifteen prospective cohorts from six countries with 239 340 women (7646 incident breast-cancer cases) of European ancestry aged 19-75 years we...
#1Débora Campanella Bastos (Harvard University)H-Index: 6
#1Débora C Bastos (Harvard University)
Last. Massimo Loda (Harvard University)H-Index: 128
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Loss of the tumor suppressor gene Pten in murine prostate recapitulates human carcinogenesis and causes stromal proliferation surrounding murine prostate intraepithelial neoplasia (mPIN), which is reactive to microinvasion. In turn, invasion has been shown to be regulated in part by de novo fatty acid synthesis in prostate cancer. We therefore investigated the effects of genetic ablation of Fasn on invasive potential in prostate-specific Pten knockout mice. Combined genetic ablation of Fasn and ...
#1Babatunde AdedokunH-Index: 15
#2Zhaohui DuH-Index: 4
Last. Qin WangH-Index: 42
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The ROOT Consortium was supported by National Cancer Institute grants R01-CA142996, R01-CA89085, R01-CA228198, and P20-CA233307. DH and OIO were also supported by Breast Cancer Research Foundation. DH and GG were also partially supported by the National Cancer Institute (R03-CA227357 and R01-CA242929). AABC was supported by a Department of Defense Breast Cancer Research Program Era of Hope Scholar Award to CAH [W81XWH-08-1-0383] and the Norris Foundation. Each of the participating AABC studies w...
#1Anna Morra (NKI-AVL: Netherlands Cancer Institute)H-Index: 1
#2Audrey Y. Jung (DKFZ: German Cancer Research Center)H-Index: 11
Last. Jenny Chang-Claude (DKFZ: German Cancer Research Center)H-Index: 123
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BACKGROUND It is not known if modifiable lifestyle factors that predict survival after invasive breast cancer differ by subtype. METHODS We analyzed data for 121,435 women diagnosed with breast cancer from 67 studies in the Breast Cancer Association Consortium with 16,890 deaths (8,554 breast cancer-specific) over 10 years. Cox regression was used to estimate associations between risk factors and 10-year all-cause mortality and breast cancer-specific mortality overall, by estrogen receptor (ER) ...
#1Doratha A. ByrdH-Index: 6
#2Emily VogtmannH-Index: 23
Last. Rashmi SinhaH-Index: 95
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The gut microbiota may play a role in breast cancer etiology by regulating hormonal, metabolic, and immunologic pathways. We investigated associations of fecal bacteria with breast cancer and non-malignant breast disease in a case-control study conducted in Ghana, a country with rising breast cancer incidence and mortality. To do this, we sequenced the V4 region of the 16S rRNA gene to characterize bacteria in fecal samples collected at the time of breast biopsy (N = 379 breast cancer cases, N =...
Cancer incidence is rising and mortality rates are high in Africa, where access to molecular pathology is limited. Analysis of cancer-related mutations in circulating tumor DNA (ctDNA) from cell-free DNA (cfDNA) that is shed into the bloodstream by tumor cells could be transformative to the African continent and provide new molecular insights. Using samples collected from the Ghana Breast Health Study we tested whether whole-genome sequencing (WGS) of cfDNA could detect ctDNA and identify somati...
#1Samuel Terkper Ahuno (KNUST: Kwame Nkrumah University of Science and Technology)
#1Samuel Terkper Ahuno (KNUST: Kwame Nkrumah University of Science and Technology)H-Index: 4
Last. Paz Polak (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 31
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ABSTRACT Circulating tumor DNA (ctDNA) sequencing studies could provide novel insights into the molecular pathology of cancer in sub-Saharan Africa. ctDNA was readily detected in 15 blood samples collected in Ghana at the time of suspected breast cancer. Genomic alterations previously associated with unfavorable prognostic outcomes were observed in the majority of patients. This supports the use of liquid biopsies for diagnosis, surveillance and clinical management of breast cancer in Ghana.
#1Doratha A. ByrdH-Index: 6
#2Emily VogtmannH-Index: 23
Last. Rashmi SinhaH-Index: 95
view all 12 authors...