Salim Yusuf
Population Health Research Institute
Internal medicineSurgeryOdds ratioCardiologyRandomized controlled trialIntensive care medicineHazard ratioAspirinHeart failureDiseaseAtrial fibrillationPopulationIn patientMyocardial infarctionRisk factorStrokeClinical trialDiabetes mellitusMedicineBlood pressureEnvironmental health
Publications 1271
#1Kazem RahimiH-Index: 59
#2Zeinab BidelH-Index: 8
Last. Larry AgodoaH-Index: 1
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Summary null null Background null The effects of pharmacological blood-pressure-lowering on cardiovascular outcomes in individuals aged 70 years and older, particularly when blood pressure is not substantially increased, is uncertain. We compared the effects of blood-pressure-lowering treatment on the risk of major cardiovascular events in groups of patients stratified by age and blood pressure at baseline. null null null Methods null We did a meta-analysis using individual participant-level dat...
#1Conor Judge (Population Health Research Institute)
#2Sukrit NarulaH-Index: 2
Last. Martin O'DonnellH-Index: 79
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Although most current guidelines recommend a daily sodium intake of less than 2.3 g/day, most people do not have a reliable estimate of their usual sodium intake. In this review, we describe the different methods used to estimate sodium intake and discuss each method in the context of specific clinical or research questions. We suggest the following classification for sodium measurement methods: preingestion measurement (controlled intake), peri-ingestion measurement (concurrent), and postingest...
#1Agneta Siegbahn (Uppsala University)H-Index: 85
#2Johan Lindbäck (Uppsala University)H-Index: 43
Last. Christopher B. Granger (Durham University)H-Index: 136
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BACKGROUND Oral anticoagulants (OAC) in patients with atrial fibrillation (AF) prevent thromboembolic events, but are associated with significant risk of bleeding. OBJECTIVES To explore associations between a wide range of biomarkers and bleeding risk in patients with AF on OAC. METHOD Biomarkers were analyzed in a random sample of 4,200 patients, 204 cases with major bleedings, from ARISTOTLE. The replication cohort included 344 cases with major bleeding and 1,024 random controls from RE-LY. Pl...
#1Tymon Pol (Uppsala University)H-Index: 1
#2Ziad Hijazi (Uppsala University)H-Index: 25
Last. Renato D. Lopes (Durham University)H-Index: 87
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AIMS Atrial fibrillation (AF) is associated with higher mortality. Biomarkers may improve the understanding of key pathophysiologic processes in AF that lead to death. Using a new multiplex analytic technique, we explored the association between 268 biomarkers and cardiovascular (CV) death in anticoagulated patients with AF. METHODS AND RESULTS A case-cohort design with 1.8 -1.9 years follow-up. The identification cohort included 517 cases and 4057 randomly selected patients from ARISTOTLE. The ...
1 CitationsSource
#1Michael Böhm (Saarland University)H-Index: 99
#1Michael BöhmH-Index: 117
Last. Felix MahfoudH-Index: 68
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#1Kamilu M. Karaye (Bayero University Kano)H-Index: 15
#2Hisham Dokainish (Population Health Research Institute)H-Index: 28
Last. Salim Yusuf (Population Health Research Institute)H-Index: 247
view all 9 authors...
Background: A wide knowledge gap exists on the clinical profiles and outcomes of heart failure (HF) in sub-Saharan Africa. null Objectives: To determine the clinical profiles and outcomes of HF patients from five African countries. null Methods: The INTERnational Congestive Heart Failure Study (INTER-CHF) is a prospective, multicenter cohort study. A total of 1,294 HF patients were consecutively recruited from Nigeria (383 patients), South Africa (169 patients), Sudan (501 patients), Uganda (151...
#1Manuel E. BaldeónH-Index: 15
#2Camilo FelixH-Index: 9
Last. Patricio Lopez-Jaramillo (Université de Sherbrooke)H-Index: 76
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Metabolic syndrome (MetS) and type 2 diabetes (T2D) are metabolic alterations associated with high morbidity and mortality, particularly in low and middle-income countries. Diet has a significant impact on the risk to develop MetS and T2D; in this regard, consumption of fruits, vegetables, and protein rich foods (from plant and animals) are important to prevent and manage these pathologies. There are limited studies regarding the potential association between Andean foods rich in proteins and th...
#1Neeraj Narula (Population Health Research Institute)H-Index: 23
#2Emily C L Wong (McMaster University)H-Index: 2
Last. Ravi Prasad VarmaH-Index: 10
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OBJECTIVE To evaluate the relation between intake of ultra-processed food and risk of inflammatory bowel disease (IBD). DESIGN Prospective cohort study. SETTING 21 low, middle, and high income countries across seven geographical regions (Europe and North America, South America, Africa, Middle East, south Asia, South East Asia, and China). PARTICIPANTS 116 087 adults aged 35-70 years with at least one cycle of follow-up and complete baseline food frequency questionnaire (FFQ) data (country specif...
#1John W. Eikelboom (Population Health Research Institute)H-Index: 121
#2Deepak L. Bhatt (Brigham and Women's Hospital)H-Index: 167
Last. Gilles Dagenais (Laval University)H-Index: 46
view all 18 authors...
Abstract null null Background null The combination of 2.5 mg rivaroxaban twice daily and 100 mg aspirin once daily compared with 100 mg aspirin once daily reduces major adverse cardiovascular (CV) events in patients with chronic coronary artery disease (CAD) or peripheral artery disease (PAD). null null null Objectives null The aim of this work was to report the effects of the combination on overall and cause-specific mortality. null null null Methods null The COMPASS trial enrolled 27,395 patie...
1 CitationsSource
#1Thomas Vanassche (Katholieke Universiteit Leuven)H-Index: 25
#2Peter Verhamme (Katholieke Universiteit Leuven)H-Index: 59
Last. Victor Aboyans (University of Limoges)H-Index: 80
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BACKGROUND In patients with coronary or peripheral arterial disease, adding low dose rivaroxaban to aspirin reduces cardiovascular events and mortality. Polypharmacy and multimorbidity are frequent in such patients. AIMS To analyze whether the benefits and risks of rivaroxaban plus aspirin varies in patients with comorbidities and receiving multiple drugs. METHODS AND RESULTS We describe ischemic events (cardiovascular death, stroke, or myocardial infarction) and major bleeding in participants f...