Guohua Jiang
Zhejiang Sci-Tech University
Composite numberMicelleTransmission electron microscopyNanoparticleCopolymerComposite materialNanotechnologyChemistryPolymer chemistryMaterials scienceTransdermalInsulinDrug deliveryGrapheneChemical engineeringPolymerizationPolymerPhotocatalysisSupercapacitorPhotochemistry
191Publications
41H-index
4,351Citations
Publications 196
Newest
#1Gao Song (ZSTU: Zhejiang Sci-Tech University)H-Index: 6
#2Yanfang Sun (ZSTU: Zhejiang Sci-Tech University)H-Index: 2
Last. Guohua Jiang (ZSTU: Zhejiang Sci-Tech University)H-Index: 41
view all 9 authors...
Abstract null null Multimodal nanoformulations with limited side-effects for tumor theranostics that catalyze a cascade of intracellular reactions show great potentials for tumor treatment with high specificity and efficiency. In this study, Cu-doped polydopamine nanoparticles (Cu-PDA NPs) have been prepared and embedded into microneedles (MNs) for photothermal and chemodynamic synergistic therapy against skin melanoma, by virtue of enhanced drug transdermal delivery owing to the unique core–she...
2 CitationsSource
#1Na Lei (ZSTU: Zhejiang Sci-Tech University)H-Index: 5
#2Pianpian Ma (ZSTU: Zhejiang Sci-Tech University)
Last. Guohua Jiang (ZSTU: Zhejiang Sci-Tech University)H-Index: 41
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Abstract The perovskite-type SrMn0.875Nb0.125O3 (SMN) and SrCo0.875Nb0.125O3 (SCN) materials are prepared through the solid-state reaction method as novel oxygen-intercalated electrode materials for supercapacitor. The crystal structure, powder morphology, and electrochemical performance have been characterized in detail. SMN exhibits a six-layer hexagonal (6H) structure with space group P63/mmc, while SCN shows the tetragonal structure of space group P4/mmm. Under the three-electrode system wit...
1 CitationsSource
#1Junzhao He (ZSTU: Zhejiang Sci-Tech University)H-Index: 2
#2Huimin Zhao (ZSTU: Zhejiang Sci-Tech University)
Last. Guohua Jiang (ZSTU: Zhejiang Sci-Tech University)H-Index: 41
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For photochromic molecules, effective isomerization usually requires conformational freedom, which is usually unavailable under solvent-free conditions. In this work, we report a new method, which can realize the reversible switching of spiropyran molecules by introducing a rigid aromatic ring group and this method can provide the required free volume to transform from a closed-ring to an open-ring form. This new molecule can quickly change color in the solid state under ultraviolet light, and c...
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#1Liming Ruan (UNNC: The University of Nottingham Ningbo China)H-Index: 1
#2Gao Song (ZSTU: Zhejiang Sci-Tech University)H-Index: 6
Last. Guohua Jiang (ZSTU: Zhejiang Sci-Tech University)H-Index: 41
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The development of multifunctional nanoformulations (NFs) include several features in a single nanosystem for these devices to overcome the disadvantages of inefficiency and undesirable toxicity of traditional therapies and provide new opportunities in the management of tumors. Herein, multifunctional CaO2@Mn-PDA NFs with a core–shell structure, integrating the photothermal conversion properties of Mn-PDA, the chemodynamic properties of doped Mn ions, and relieving hypoxia in the tumor microenvi...
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#1Yaping Wang (ZSTU: Zhejiang Sci-Tech University)H-Index: 2
#2Songyue Cheng (ZSTU: Zhejiang Sci-Tech University)
Last. Guohua Jiang (ZSTU: Zhejiang Sci-Tech University)H-Index: 41
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Abstract null null A self-regulated anti-diabetic drug release device mimicking pancreatic cells is highly desirable for the therapy of diabetes. Herein, a glucose-mediated dual-responsive drug delivery system, which combines pH- and H2O2-responsive block copolymer grafted hollow mesoporous silica nanoparticles (HMSNs) with microneedle (MN) array patch, has been developed to achieve self-regulated administration. The poly[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl acrylate]-b-poly[2-(...
1 CitationsSource
#1Zhiyong Zeng (ZSTU: Zhejiang Sci-Tech University)H-Index: 1
#2Guohua Jiang (ZSTU: Zhejiang Sci-Tech University)H-Index: 41
Last. Yufei Shi (ZSTU: Zhejiang Sci-Tech University)
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Injection therapy for diabetes has poor patient compliance, and the pain occurring at the site of subcutaneous injections causes significant inconvenience to diabetic patients. In this work, to demonstrate the benefits of an alternative drug delivery technique that overcomes these issues, methacrylated gelatin hydrogel-forming microneedles integrated with metformin were developed to adjust blood glucose levels in diabetic rats. Gelatin methacryloyl microneedles (GelMA-MNs) with different degrees...
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#1Xueya Zhang (ZSTU: Zhejiang Sci-Tech University)H-Index: 1
#2Guohua Jiang (ZSTU: Zhejiang Sci-Tech University)H-Index: 41
Last. Zhiyong Zeng (ZSTU: Zhejiang Sci-Tech University)H-Index: 1
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#1Yuhui YangH-Index: 14
#2He ZheH-Index: 2
Last. Guohua JiangH-Index: 41
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Efficient isomerization of photochromic molecules requires conformational freedom and is often limited to the solution or polymer matrix. Thus, developing a new method to improve photochromism in the solid state is quite necessary. In this work, we design and synthesize two dendritic photochromic molecules by incorporating spiropyran chromophores onto bisphenol A (BPA) or 1,1,1-tris(4-hydroxyphenyl)ethane (Tri-OH) via a mild esterification reaction, which show distinguished reversible photochrom...
1 CitationsSource
#1Tianqi Liu (ZSTU: Zhejiang Sci-Tech University)H-Index: 6
#2Gao Song (ZSTU: Zhejiang Sci-Tech University)H-Index: 6
Last. Guohua Jiang (ZSTU: Zhejiang Sci-Tech University)H-Index: 41
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Microneedles have been developed rapidly in the field of transdermal administration in the past few decades. In recent years, the development of microelectronics technology has expanded the applications of microneedles by combining with microelectronic systems, especially in biological diagnosis and treatment. Different types of microneedles have been designed to extract blood and tissue fluids for detection, or as electrodes to directly detect blood sugar, melanoma and pH in real-time in vivo, ...
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#1Tianqi Liu (ZSTU: Zhejiang Sci-Tech University)H-Index: 6
#2Guohua Jiang (ZSTU: Zhejiang Sci-Tech University)H-Index: 41
Last. Zhiyong Zeng (ZSTU: Zhejiang Sci-Tech University)H-Index: 1
view all 6 authors...
In this work, the rapidly separable microneedles (MNs) consisted of needle-tips and supporting bases have been fabricated by a step-by-step coating method. Poly (vinyl alcohol) (PVA) have been used to prepare the needle-tips of MNs in which they are capped on the solvable supporting bases consisted of sodium bicarbonate, poly (vinyl pyrolidone) (PVP), and tartaric acid (TA) (NaHCO3/PVP/TA). After insertion into the skin, the needle-tips can be separated rapidly from the patches within 90 s due t...
2 CitationsSource