Sameera R. Samarakoon
University of Colombo
CytotoxicityCaspase 3Molecular biologyCytotoxic T cellChemistryApoptosisDecoctionIn vitroSurvivinSulforhodamine BOxidative stressSmilax glabraHemidesmus indicusStem cellChromatographyDNA fragmentationReactive oxygen speciesCancer researchBreast cancerBiochemistryTraditional medicineMedicineCell cultureBiologyPharmacology
56Publications
12H-index
514Citations
Publications 56
Newest
The current study aimed to test the cytotoxic efficacy of silver nanoparticles (Ag-NPs) synthesized using polysaccharide from marine algae Chnoospora minima against Human Breast Cancer (MCF-7) Cells in vitro. The extracted polysaccharide and the synthesized Ag-NPs were analyzed by Fourier-transform infrared spectroscopy (FTIR). Biosynthesized silver nanoparticles (Ag-NPs) were characterized using UV-spectrophotometry, dynamic light scattering (DLS), Zeta Potential, Scanning electron microscopy (...
#1Dennis Kariuki Muthoni (UoC: University of Colombo)
#2Sameera R. Samarakoon (UoC: University of Colombo)H-Index: 12
Last. Meran Keshawa Ediriweera (UoC: University of Colombo)H-Index: 10
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This study was conducted to determine the anti-cancer activity of 3-O-α-L-arabinosyl oleanolic acid (3-O-L-AO), a triterpenoid saponin, isolated from the leaves of Schumacheria castaneifolia Vahl in breast cancer stem cells (bCSCs) grown in hypoxia. Anti-proliferative effects of 3-O-L-AO in bCSCs were determined using WST-1 assay. Real-time PCR was employed to evaluate the effects of 3-O-L-AO on apoptosis. Compound 3-O-L-AO exerted greater anti-proliferative effect in bCSCs grown under hypoxic c...
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#1Varuni Colamba Pathiranage (UoC: University of Colombo)H-Index: 2
#2Jesiska Nirmalee Lowe (UoC: University of Colombo)H-Index: 1
Last. Sameera R. Samarakoon (UoC: University of Colombo)H-Index: 12
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Development of therapy resistance is a major clinical issue in breast cancer treatments. Breast cancer stem cells (bCSCs) have a clearly defined role in the development of breast cancer therapy resistance and tumor recurrence. Therefore, discovery of new treatment strategies to circumvent cancer therapy resistance and tumor recurrence by targeting bCSCs is desperately needed. Fruits of many Garcinia species are edible and, possess a range of health benefits. Garcinia quaesita, a species in the g...
1 CitationsSource
Garcinol (GA), a polyisoprenylated benzophenone derivative, is one of the major phytochemicals found in a number of fruits of Garcinia. This study aimed to develop a new nanodelivery system comprising GA, hyaluronic acid (HA), and poly(lactic-co-glycolic acid) (PLGA) to actively target breast cancer stem cells (bCSCs) grown under hypoxic conditions. HA has been reported to show higher affinity for the cluster-determinant 44 receptor (CD44), while PLGA is an FDA-approved biodegradable polymer use...
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#1Nadini Thushara (USJP: University of Sri Jayewardenepura)H-Index: 1
Last. Theshini Perera (USJP: University of Sri Jayewardenepura)H-Index: 6
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Three new Pt complexes, [PtCl2(N(SO2(2-nap))dpa)], [PtCl2(N(SO2(1-nap))dpa)] and [PtCl2(N(SO2pip)dpa)], containing a rare 8-membered ring were synthesized in good yield and high purity by utilizing the ligands N(SO2(2-nap))dpa, N(SO2(1-nap))dpa and N(SO2pip)dpa, which contain a dipicolylamine moiety. Structural studies of all three complexes confirmed that the ligands are bound in a bidentate mode via Pt–N(pyridyl) bonds forming a rare 8-membered ring. The intense fluorescence displayed by the l...
#1Taniya Darshani (USJP: University of Sri Jayewardenepura)H-Index: 1
#2Frank R. Fronczek (LSU: Louisiana State University)H-Index: 59
Last. Theshini Perera (USJP: University of Sri Jayewardenepura)H-Index: 6
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Abstract Rhenium complexes have possible fluorescence imaging, radioimaging and therapeutic applications and can also serve as a model system for 99mTc. The quest for new pharmaceutical agents is thus an expanding area of research. In this study, we report two net neutral complexes, [Re(CO)3(N(SO2)(1-nap)dien)] and [Re(CO)3(N(SO2)(2-nap)dien)], synthesized by treating fac-[Re(CO)3(H2O)3]+ with two novel tridentate ligands, (N(SO2)(1-nap)dienH and N(SO2)(2-nap)dienH), derived from diethylenetriam...
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#1Sinthujah Santhirasegaram (University of Kelaniya)H-Index: 1
#2S. Wickramarachchi (University of Kelaniya)H-Index: 2
Last. Priyani Paranagama (University of Kelaniya)H-Index: 14
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The lichen host, Amandinea medusulina, collected from mangrove habitats in Sri Lanka, and its associated endolichenic fungi were isolated and identified by rDNA-ITS sequence analysis and morphologi...
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#1Varuni Colamba Pathiranage (UoC: University of Colombo)H-Index: 2
#2Ira Thabrew (UoC: University of Colombo)H-Index: 8
Last. Meran Keshawa Ediriweera (UoC: University of Colombo)H-Index: 10
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Abstract Objective The present work tested organic solvents to prepare an extract with anticancer properties from a polyherbal mixture containing Nigella sativa (seeds), Hemidesmus indicus (roots) and Smilax glabra (rhizomes). We evaluate anticancer effects in non-small-cell lung cancer cells (NCI-H292), and discuss optimization for pharmaceutical use in the context of efficacy, yield and toxicity. Methods Using different organic solvents, six extracts were prepared from the polyherbal mixture. ...
1 CitationsSource
AbstractDuring the last three decades, studies of linamarin extracted from cassava have received increased attention due to the presence of high cyanogenic compounds in these extracts. The methods ...
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Last. Kamani H. TennekoonH-Index: 17
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1 CitationsSource