Brianna M. Paul
University of California, San Francisco
Verbal memoryDevelopmental psychologyCognitive developmentNeuropsychologyDiffusion MRIPsychologyNeuroscienceCognitionCognitive psychologyYoung adultCingulum (brain)NeocortexEpilepsyEpilepsy syndromesFunctional magnetic resonance imagingFace (sociological concept)Uncinate fasciculusArcuate fasciculusBody mass indexTask (project management)Inferior longitudinal fasciculusTemporal lobeWhite matterWilliams syndromePopulationCognitive declineNeural systemVerbal learningMemory impairmentConnectomeAudiologyNeuroimagingMedicineBiologyEpisodic memoryWechsler Adult Intelligence ScaleFractional anisotropy
27Publications
11H-index
737Citations
Publications 27
Newest
#1Sanam J. Lalani (UCSF: University of California, San Francisco)H-Index: 3
#2Anny Reyes (UCSD: University of California, San Diego)H-Index: 10
Last. Carrie R. McDonald (UCSD: University of California, San Diego)H-Index: 38
view all 11 authors...
OBJECTIVE Episodic memory impairment and hippocampal pathology are hallmark features of both temporal lobe epilepsy (TLE) and amnestic mild cognitive impairment (aMCI). Pattern separation (PS), which enables the distinction between similar but unique experiences, is thought to contribute to successful encoding and retrieval of episodic memories. Impaired PS has been proposed as a potential mechanism underling episodic memory impairment in aMCI, but this association is less established in TLE. In...
1 CitationsSource
#1Roxanne L Simmons (UCSF: University of California, San Francisco)H-Index: 1
#2Haiyan Li (UCSF: University of California, San Francisco)H-Index: 8
Last. Susan M. Voglmaier (UCSF: University of California, San Francisco)H-Index: 15
view all 20 authors...
Clinical and genetic features of five unrelated patients with de novo pathogenic variants in the synaptic vesicle associated membrane protein VAMP2 reveal common features of global developmental delay, autistic tendencies, behavioral disturbances, and a higher propensity to develop epilepsy. For one patient, a cognitively impaired adolescent with a de novo stop-gain VAMP2 mutation, we tested a potential treatment strategy, enhancing neurotransmission by prolonging action potentials with the amin...
1 CitationsSource
#1Akshara R. Balachandra (MUSC: Medical University of South Carolina)H-Index: 6
#1Akshara R. Balachandra (MUSC: Medical University of South Carolina)H-Index: 2
Last. Carrie R. McDonaldH-Index: 38
view all 9 authors...
Objective To determine the predictive power of white matter neuronal networks (i.e., structural connectomes [SCs]) in discriminating memory-impaired patients with temporal lobe epilepsy (TLE) from those with normal memory. Methods T1- and diffusion MRI (dMRI), clinical variables, and neuropsychological measures of verbal memory were available for 81 patients with TLE. Prediction of memory impairment was performed with a tree-based classifier (XGBoost) for 4 models: (1) a clinical model including...
3 CitationsSource
#1Anny Reyes (UCSD: University of California, San Diego)H-Index: 10
#2Sanam J. Lalani (UCSF: University of California, San Francisco)H-Index: 3
Last. Carrie R. McDonald (UCSD: University of California, San Diego)H-Index: 38
view all 9 authors...
Abstract Cerebrovascular risk factors (CVRFs) and comorbid cardiovascular and metabolic disease have been linked to accelerated cognitive aging and dementia in the general population; however, the contribution of these comorbidities to the risk of post anterior temporal lobectomy (ATL) memory decline has been unexamined. We explored the effects of CVRFs on postoperative verbal memory decline in a cohort of 22 patients with left temporal lobe epilepsy (LTLE) who completed pre- and one-year postsu...
1 CitationsSource
#1Erik Kaestner (UCSD: University of California, San Diego)H-Index: 10
#2Akshara R. Balachandra (UCSD: University of California, San Diego)H-Index: 6
Last. Carrie R. McDonald (UCSD: University of California, San Diego)H-Index: 38
view all 11 authors...
ABSTRACT Objective The distributed white matter network underlying language leads to difficulties in extracting clinically meaningful summaries of neural alterations leading to language impairment. Here we determine the predictive ability of the structural connectome (SC), compared with global measures of white matter tract microstructure and clinical data, to discriminate language impaired patients with temporal lobe epilepsy (TLE) from TLE patients without language impairment. Methods T1- and ...
8 CitationsSource
#1Erik Kaestner (UCSD: University of California, San Diego)H-Index: 10
#2Anny Reyes (UCSD: University of California, San Diego)H-Index: 10
Last. Carrie R. McDonald (UCSD: University of California, San Diego)H-Index: 38
view all 7 authors...
OBJECTIVE: To identify neuroimaging and clinical biomarkers associated with a language-impaired phenotype in refractory temporal lobe epilepsy (TLE). METHODS: Eighty-five patients with TLE were characterized as language-impaired (TLE-LI) or non-language-impaired (TLE-NLI) based on comprehensive neuropsychological testing. Structural magnetic resonance imaging (MRI), diffusion tensor imaging, and functional MRI (fMRI) were obtained in patients and 47 healthy controls (HC). fMRI activations and co...
14 CitationsSource
#1Yu-Hsuan A. Chang (UCSD: University of California, San Diego)H-Index: 7
#2Anisa Marshall (UCSD: University of California, San Diego)H-Index: 5
Last. Carrie R. McDonaldH-Index: 38
view all 11 authors...
OBJECTIVES: Temporal lobe epilepsy (TLE) is known to affect large-scale gray and white matter networks, and these network changes likely contribute to the verbal memory impairments observed in many patients. In this study, we investigate multimodal imaging patterns of brain alterations in TLE and evaluate the sensitivity of different imaging measures to verbal memory impairment. METHODS: Diffusion tensor imaging (DTI), volumetric magnetic resonance imaging (vMRI), and resting-state functional MR...
4 CitationsSource
#1Anny ReyesH-Index: 10
#2Erik KaestnerH-Index: 10
Last. Carrie R. McDonaldH-Index: 38
view all 8 authors...
Objective To identify distinct cognitive phenotypes in temporal lobe epilepsy (TLE) and evaluate patterns of white matter (WM) network alterations associated with each phenotype. Methods Seventy patients with TLE were characterized into 4 distinct cognitive phenotypes based on patterns of impairment in language and verbal memory measures (language and memory impaired, memory impaired only, language impaired only, no impairment). Diffusion tensor imaging was obtained in all patients and in 46 hea...
25 CitationsSource
#1Tobin J. Ehrlich (Palo Alto University)H-Index: 2
#2Anny Reyes (UCSD: University of California, San Diego)H-Index: 10
Last. Carrie R. McDonaldH-Index: 38
view all 10 authors...
Abstract Objective Individuals with temporal lobe epilepsy (TLE) often experience diminished quality of life (QoL). Although comorbid depression is one of the most recognized predictors of poor QoL in TLE, impairments in verbal memory (VM) and executive functioning (EF), have also been identified as risk factors, independent of other biological and psychosocial factors. In this study, we examine the contribution of depression, VM, and EF to QoL in 52 well-characterized medically-refractory TLE p...
4 CitationsSource
#1Anny Reyes (UCSD: University of California, San Diego)H-Index: 10
#2Brianna M. Paul (UCSF: University of California, San Francisco)H-Index: 11
Last. Carrie R. McDonald (UCSD: University of California, San Diego)H-Index: 38
view all 10 authors...
OBJECTIVE: Bilingual healthy adults have been shown to exhibit an advantage in executive functioning (EF) that is associated with microstructural changes in white matter (WM) networks. Patients with temporal lobe epilepsy (TLE) often show EF deficits that are associated with WM compromise. In this study, we investigate whether bilingualism can increase cognitive reserve and/or brain reserve in bilingual patients with TLE, mitigating EF impairment and WM compromise. METHODS: Diffusion tensor imag...
6 CitationsSource