Marion K. Gordon
Rutgers University
Messenger RNAAnatomyDownregulation and upregulationPathologyMolecular biologyChemistryExtracellular matrixImmunologyBasement membraneCorneaNitrogen mustardWound healingSulfur mustardCollagen, type I, alpha 1Cancer researchBiochemistryMedicineBiologyCell biologyPharmacology
100Publications
21H-index
1,716Citations
Publications 100
Newest
#1Laurie B. Joseph (RU: Rutgers University)H-Index: 12
#2Marion K. Gordon (RU: Rutgers University)H-Index: 21
Last. Jeffrey D. Laskin (RU: Rutgers University)H-Index: 69
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Sulfur mustard (SM; bis (2-chloroethyl) sulfide) is a potent vesicant which causes irritation of the conjunctiva and damage to the cornea. In the present studies, we characterized the ocular effects of SM in New Zealand white rabbits. Within one day of exposure to SM, edema and hazing of the cornea were observed, followed by neovascularization which persisted for at least 28 days. This was associated with upper and lower eyelid edema and conjunctival inflammation. The conjunctiva is composed of ...
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#1Andrea DeSantis-Rodrigues (RU: Rutgers University)H-Index: 2
#2Rita A. Hahn (RU: Rutgers University)H-Index: 8
Last. Marion K. Gordon (RU: Rutgers University)H-Index: 21
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Amino-Plex (SM1997) is a spray or liquid cosmeceutical that has been used for skin dryness, aging, or sun exposure. Its formulation includes electrolytes, trace minerals, amino acids, peptides, nucleosides and nucleotides, all substances that are less than 10 kDa. It is designed to increase oxygen levels in cells, improve glucose transport, stimulate ATP synthesis, and stimulate collagen formation, actions that can help facilitate repair of damaged cells. It also supports collagen synthesis and ...
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#1Yoke-Chen Chang (RU: Rutgers University)H-Index: 7
#2Rita A. Hahn (RU: Rutgers University)H-Index: 8
Last. Donald R. Gerecke (RU: Rutgers University)H-Index: 18
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Abstract Sulfur mustard (SM) is a highly toxic blistering agent thought to mediate its action, in part, by activating matrix metalloproteinases (MMPs) in the skin and disrupting components of the basement membrane zone (BMZ). Type IV collagenases (MMP-9) degrade type IV collagen in the skin, a major component of the BMZ at the dermal-epidermal junction. In the present studies, a type IV collagenase inhibitor, N-hydroxy-3-phenyl-2-(4-phenylbenzenesulfonamido) propanamide (BiPS), was tested for it...
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: The idea and meetings that planned this issue focused on extracellular matrix (ECM) started over 4 years ago. The invitations were sent to investigators over 2 years ago and manuscripts have been submitted, reviewed, and edited since the summer and fall of 2018. Most of the manuscripts were published in early view in 2019, and we are thrilled to share the final collection. This volume contains 6 reviews, 13 original research papers, and 4 remembrances. Marion (Emmy) Gordon and I organized the ...
1 CitationsSource
#1Yoke Chen Chang (RU: Rutgers University)H-Index: 3
#2James D. Wang (RU: Rutgers University)H-Index: 2
Last. Donald R. Gerecke (RU: Rutgers University)H-Index: 18
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: Laminin-332 is a basement membrane protein composed of three genetically distinct polypeptide chains that actively promote both skin epidermal cell adhesion and migration. Proteolytic fragments of the laminin γ2 chain stimulate migration and scattering of keratinocytes and cancer cells. Sulfur mustard (SM) is a bifunctional alkylating agent that induces separation of basal keratinocytes from the dermal-epidermal junction and invokes a strong inflammatory response leading to delayed wound repai...
1 CitationsSource
#1Marion K. Gordon (RU: Rutgers University)H-Index: 21
#2Donald R. Gerecke (RU: Rutgers University)H-Index: 18
Last. Yoke-Chen Chang (RU: Rutgers University)H-Index: 7
view all 6 authors...
1 CitationsSource
#1Yoke-Chen ChangH-Index: 7
#2Selina MuhnH-Index: 1
Last. Donald R. GereckeH-Index: 18
view all 5 authors...
1 CitationsSource
#1Marion K. Gordon (RU: Rutgers University)H-Index: 21
#2Rita Hahn (RU: Rutgers University)H-Index: 3
Last. Donald R. Gerecke (RU: Rutgers University)H-Index: 18
view all 5 authors...