Kimihiro Shimizu
Shinshu University
GeneCancerInternal medicineRadiologySurgeryPathologyOncologyCardiothoracic surgeryImmunohistochemistryPositron emission tomographyLung cancerCarcinomaLungEpidermal growth factor receptorAdenocarcinomaNon small cellCancer researchMedicineBiologyGastroenterology
267Publications
33H-index
3,621Citations
Publications 268
Newest
#1Kimihiro Shimizu (Shinshu University)H-Index: 2
#1Kimihiro Shimizu (Shinshu University)H-Index: 33
Last. Masayuki Chida (Dokkyo Medical University)H-Index: 17
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Abstract Background The aim of this study is to describe the characteristics and outcomes of patients with non-small-cell lung cancer undergoing salvage surgery after chemoradiotherapy, conventional external beam, stereotactic body radiotherapy (SBRT), and ion beam radiotherapy. Methods We retrospectively evaluated patients who underwent salvage surgery between 2010 and 2016. Data on perioperative morbidity and mortality and patient outcomes were analyzed. Results In total, 156 patients were inc...
1 CitationsSource
With the progress of surgical instruments and surgical techniques, endoscopic surgery has become remarkably widespread, and techniques of the thoracoscopic surgery are considered to have become common. It is not uncommon to encounter cases with intrathoracic pleural adhesions, such as not only a history of intrathoracic inflammatory disease, but also second cancer after resection of early-stage lung cancer and multiple operations for metastatic lung tumor. It is important for thoracic surgeons t...
#1Yoichi Ohtaki (Gunma University)H-Index: 14
#2Kimihiro Shimizu (Shinshu University)H-Index: 33
Last. Masayuki Chida (Dokkyo Medical University)H-Index: 17
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Abstract Objectives The prognostic impact of surgical intervention for recurrent or residual non-small cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR) mutation or anaplastic lymphoma kinase (ALK) rearrangement after tyrosine-kinase inhibitor (TKI) treatment remains unclear. We aimed to describe the characteristics and outcomes of patients undergoing salvage surgery in this setting. Methods We retrospectively collected and analyzed nationwide Japanese data on perioperat...
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#1Hirotaka KumedaH-Index: 2
#2Kazutoshi HamanakaH-Index: 11
Last. Kimihiro ShimizuH-Index: 33
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#1Tsutomu KoyamaH-Index: 3
Last. Kimihiro ShimizuH-Index: 2
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#1Tetsu TakedaH-Index: 5
#2Takashi EguchiH-Index: 16
Last. Kimihiro ShimizuH-Index: 33
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#1Erkhem-Ochir Bilguun (Gunma University)H-Index: 2
#2Kyoichi Kaira (Saitama Medical University)H-Index: 46
Last. Masahiko Nishiyama (Gunma University)H-Index: 20
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Lung squamous cell carcinoma (LSCC) remains a challenging disease to treat, and further improvements in prognosis are dependent upon the identification of LSCC-specific therapeutic biomarkers and/or targets. We previously found that Syntaxin Binding Protein 4 (STXBP4) plays a crucial role in lesion growth and, therefore, clinical outcomes in LSCC patients through regulation of tumor protein p63 (TP63) ubiquitination. To clarify the impact of STXBP4 and TP63 for LSCC therapeutics, we assessed rel...
2 CitationsSource
#1Kimihiro Shimizu (Gunma University)H-Index: 33
#2Kyoichi Kaira (Saitama University)H-Index: 5
Last. Ken Shirabe (Gunma University)H-Index: 75
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Purpose 3-[18F]Fluoro-α-methyl-L-tyrosine ([18F]FAMT) is an amino acid positron emission tomography (PET) tracer specific for cancer detection by assessment of tumor amino acid metabolism. Little is known on whether or not the uptake of [18F]FAMT within cancer cells is associated with the expression of programmed death ligand-1 (PD-L1), a predictor of anti-PD-1 antibody efficacy. We conducted a clinicopathological study to assess the expression of PD-L1 and the presence of tumor-infiltrating lym...
1 CitationsSource
#2Kaira KyoichiH-Index: 1
Last. Masahiko NishiyamaH-Index: 20
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#1Takamichi Igarashi (Gunma University)H-Index: 9
#2Kimihiro Shimizu (Gunma University)H-Index: 33
Last. Ken Shirabe (Gunma University)H-Index: 75
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Background RAS/BRAF mutations of colorectal cancer (CRC) play a crucial role in carcinogenesis and cancer progression and need to be considered for the therapeutic strategy choice. We used next-generation-sequencing (NGS) technology to assess RAS/BRAF mutation differences between primary CRC and corresponding pulmonary metastases (PMs).
3 CitationsSource