Kwang Seok Ahn
Kyung Hee University
CancerInternal medicineSTAT proteinKinaseChemistryApoptosisSurvivinSTAT3AngiogenesisCancer researchBiochemistryCell growthSignal transductionMedicineProtein kinase BPI3K/AKT/mTOR pathwayBiologyCell biologyCancer cellPharmacology
237Publications
50H-index
6,597Citations
Publications 299
Newest
#1Woo Yong Park (Kyung Hee University)H-Index: 1
#2Jinbong Park (Kyung Hee University)H-Index: 15
Last. Jae-Young Um (Kyung Hee University)H-Index: 33
view all 8 authors...
Abstract null null Non-shivering thermogenesis (NST) is a heat generating process controlled by the mitochondria of brown adipose tissue (BAT). In the recent decade, ‘functionally’ acting brown adipocytes in white adipose tissue (WAT) has been identified as well: the so-called process of the ‘browning’ of WAT. While the importance of uncoupling protein 1 (UCP1)-oriented mitochondrial activation has been intensely studied, the role of peroxisomes during the browning of white adipocytes is poorly ...
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#1Milad Ashrafizadeh (Sabancı University)H-Index: 9
#2Ali Zarrabi (Sabancı University)H-Index: 20
Last. Alan Prem Kumar (NUS: National University of Singapore)H-Index: 68
view all 15 authors...
Abstract null null Cancer is the second leading cause of death worldwide. Majority of recent research efforts in the field aim to address why cancer resistance to therapy develops and how to overcome or prevent it. In line with this, novel anti-cancer compounds are desperately needed for chemoresistant cancer cells. Phytochemicals, in view of their pharmacological activities and capacity to target various molecular pathways, are of great interest in the development of therapeutics against cancer...
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#1Min Hee Yang (Kyung Hee University)H-Index: 6
#2In Jin Ha (Kyung Hee University)H-Index: 4
Last. Kwang Seok Ahn (Kyung Hee University)H-Index: 50
view all 5 authors...
Objectives null Ginkgolide C (GGC) isolated from Ginkgo biloba (Ginkgoaceae) leaf can demonstrate pleiotropic pharmacological actions. However, its anti-oncogenic impact in non-small cell lung cancer (NSCLC) model has not been reconnoitered. As signal transducer and activator of transcription 3 (STAT3) cascade can promote tumour growth and survival, we contemplated that GGC may interrupt this signalling cascade to expend its anti-cancer actions in NSCLC. null Methods null The effect of GGC on ST...
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#1Chakrabhavi Dhananjaya Mohan (University of Mysore)H-Index: 24
#2Chulwon Kim (Kyung Hee University)H-Index: 27
Last. Kwang Seok Ahn (Kyung Hee University)H-Index: 50
view all 10 authors...
STAT3 is a key oncogenic transcription factor, often overactivated in several human cancers including hepatocellular carcinoma (HCC). STAT3 modulates the expression of genes that are connected with cell proliferation, antiapoptosis, metastasis, angiogenesis, and immune evasion in tumor cells. In this study, we investigated the effect of crocetin on the growth of HCC cells and dissected its underlying molecular mechanism in imparting a cytotoxic effect. Crocetin suppressed proliferation, promoted...
1 CitationsSource
#1Sakshi Sikka (NUS: National University of Singapore)H-Index: 6
#2Muthu K. Shanmugam (NUS: National University of Singapore)H-Index: 52
Last. Tahani Awad Alahmadi (King Khalid University)H-Index: 5
view all 16 authors...
Prostate cancer (PCa) is a common disease among men especially in the old age. The deregulated activation of oncogenic and pro-survival transcription factors has been linked with tumor progression in PCa patients. The consequence of diosgenin treatment on NF-κB/STAT3 activation in PCa cells as well as transgenic mouse model was determined. We also validated the hypothesis of targeting these transcription factors using in silico proteomics simulation model. Diosgenin abrogated NF-κB/STAT3 activat...
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#1Woo Yong ParkH-Index: 1
#2Gahee SongH-Index: 2
Last. Jinbong ParkH-Index: 15
view all 9 authors...
The extract of the Gardenia jasminoides fruit (GJFE) can been consumed as an herbal tea or used as a yellow dye. Recently, studies report that GFJE exerts inhibitory effects on lipid accumulation and adipogenesis in white adipocytes. We evaluated the thermogenic actions of GJFE by focusing on mitochondrial activation and studying the underlying mechanisms. To investigate the role of GJFE on thermogenesis in mice, we used an acute cold exposure model. After 2 weeks of feeding, the cold tolerance ...
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#1Hiu Yan Lam (Institute of Molecular and Cell Biology)H-Index: 1
#2Vinay Tergaonkar (Institute of Molecular and Cell Biology)H-Index: 54
Last. Kwang Seok Ahn (Kyung Hee University)H-Index: 50
view all 4 authors...
Mast cells (MCs) are innate immune cells that widely distribute throughout all tissues and express a variety of cell surface receptors. Upon activation, MCs can rapidly release a diverse array of preformed mediators residing within their secretory granules and newly synthesize a broad spectrum of inflammatory and immunomodulatory mediators. These unique features of MCs enable them to act as sentinels in response to rapid changes within their microenvironment. There is increasing evidence now tha...
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#1Young Yun Jung (Kyung Hee University)H-Index: 6
#2Seung Ho Baek (Dongguk University)H-Index: 12
Last. Kwang Seok Ahn (Kyung Hee University)H-Index: 50
view all 6 authors...
Abstract null null Aims null Tumor cells metastasis as well as proliferation are important factors that can substantially determines the prognosis of cancer. In particular, epithelial–mesenchymal transition (EMT) is key phenomena which can cause tumor cell transition into other organs by promoting the disruption of the cell-cell junctions. Because oxymatrine (OMT) have been reported to attenuate the tumor growth, we investigated whether OMT can down-regulate EMT process in tumor cells. We also f...
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#1Min Hee Yang (Kyung Hee University)H-Index: 6
#2In Jin Ha (Kyung Hee University)H-Index: 4
Last. Kwang Seok Ahn (Kyung Hee University)H-Index: 50
view all 6 authors...
Ginkgolide C (GGC), isolated from Ginkbiloba, has been reported to display various pharmacological actions, although, anti-cancer effect of GGC has been poorly understood till now. This study aimed to investigate whether GGC can exhibit anti-neoplastic effects against colon cancer cells and explore underlying mechanism. The Wnt/β-catenin signaling can regulate cell proliferation, survival, metastasis, and migration. Wnt/β-catenin signaling pathway plays important role in colorectal cancer (CRC) ...
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#1Sosmitha Girisa (IITG: Indian Institute of Technology Guwahati)H-Index: 8
#2Queen Saikia (IITG: Indian Institute of Technology Guwahati)
Last. Ajaikumar B. Kunnumakkara (IITG: Indian Institute of Technology Guwahati)H-Index: 58
view all 9 authors...
Cancer is a major public health concern due to high mortality and poor quality of life of patients. Despite the availability of advanced therapeutic interventions, most treatment modalities are not efficacious, very expensive, and cause several adverse side effects. The factors such as drug resistance, lack of specificity, and low efficacy of the cancer drugs necessitate developing alternative strategies for the prevention and treatment of this disease. Xanthohumol (XN), a prenylated chalcone pr...
1 CitationsSource