Kwang Seok Ahn
Kyung Hee University
PhosphorylationCancerSTAT proteinKinaseChemistryApoptosisSurvivinSTAT3AngiogenesisCancer researchBiochemistryCell growthSignal transductionMedicineProtein kinase BTranscription factorPI3K/AKT/mTOR pathwayBiologyCancer cellPharmacology
275Publications
56H-index
11.2kCitations
Publications 271
Newest
#1Young Yun Jung (Kyung Hee University)H-Index: 6
#2Jeong-Hyeon Ko (Kyung Hee University)H-Index: 13
Last. Kwang Seok Ahn (Kyung Hee University)H-Index: 56
view all 7 authors...
Hypercholesterolemia has been found to be closely linked with a significant increase in both cancer incidence and mortality. However, the exact correlation between serum cholesterol levels and cancer has not been completely deciphered. Here we analyzed the effect of low-density lipoprotein (LDL) cholesterol on prostate and pancreatic cancer cells. We noted that LDL induced a substantial STAT3 activation and JAK1, JAK2, Src activation in diverse prostate and pancreatic tumor cells. Moreover, LDL ...
1 CitationsSource
#1Woo Yong Park (Kyung Hee University)H-Index: 1
#2Jinbong Park (Kyung Hee University)H-Index: 14
Last. Jae-Young Um (Kyung Hee University)H-Index: 30
view all 5 authors...
To determine whether ellagic acid (EA) induces the "beige remodeling" of white adipose tissue (WAT), we treated cold-exposed mice and mouse stromal vascular fraction (SVF) cells with EA, a phytochemical abundant in fruits and vegetables, in particular berries. We then investigated the mechanism of EA in beige remodeling with a particular focus on DRP1-mediated mitochondrial fission and SIRT3. EA induced the trans-differentiation of white adipocytes to beige adipocytes by promoting the expression...
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#1Alessio BiagioniH-Index: 12
#2Shima Tavakol (IUMS: Iran University of Medical Sciences)H-Index: 20
Last. Kwang Seok AhnH-Index: 56
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The small nucleolar RNA host genes (SNHGs) belong to the long non-coding RNAs and are reported to be able to influence all three levels of cellular information-bearing molecules, i.e. DNA, RNA and proteins, resulting in the generation of complex phenomena. As the host genes of the small nucleolar RNAs (snoRNAs), they are commonly localized in the nucleolus, where they exert multiple regulatory functions orchestrating cellular homeostasis and differentiation as well as metastasis and chemoresista...
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#1Sepideh MirzaeiH-Index: 1
#2Kiavash HushmandiH-Index: 5
Last. Kwang Seok AhnH-Index: 56
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The failure of chemotherapy is a major challenge nowadays, and in order to ensure effective treatment of cancer patients, it is of great importance to reveal the molecular pathways and mechanisms involved in chemoresistance. Cisplatin (CP) is a platinum-containing drug with anti-tumor activity against different cancers in both pre-clinical and clinical studies. However, drug resistance has restricted its potential in the treatment of cancer patients. CP can promote levels of free radicals, parti...
1 CitationsSource
#1Young Yun Jung (Kyung Hee University)H-Index: 6
#2Jae-Young Um (Kyung Hee University)H-Index: 30
Last. Kwang Seok Ahn (Kyung Hee University)H-Index: 56
view all 6 authors...
Abstract Background: Leelamine (LEE) is a lipophilic diterpene amine phytochemical, which can be naturally extracted from pine's bark trees. It has been extensively studied recently for its promising chemopreventive and anti-cancer effects against various cancers such as that of prostate and breast. Hypothesis: We examined the potential impact of LEE in affecting the activation of signal transducer and activator of transcription 3 (STAT3) and promoting apoptosis in human multiple myeloma (MM) ce...
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#1Min Hee Yang (Kyung Hee University)H-Index: 6
#2Seung Ho Baek (Dongguk University)H-Index: 2
Last. Kwang Seok Ahn (Kyung Hee University)H-Index: 56
view all 5 authors...
Brassinin (BSN), a precursor of phytoalexins, extracted from Chinese cabbage has been reported to act as a promising anti-neoplastic agent. However, the effects of BSN on colon cancer cells and its underlying mechanisms have not been fully elucidated. This study aimed at investigating the anti-neoplastic impact of BSN and its possible synergistic effect with paclitaxel on colon cancer cells. The effect of BSN on Janus-activated kinases (JAKs)/signal transducer and activator of transcription 3 (S...
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#1Min Hee Yang (Kyung Hee University)H-Index: 6
#2Seung Ho Baek (Dongguk University)H-Index: 2
Last. Kwang Seok Ahn (Kyung Hee University)H-Index: 56
view all 5 authors...
2 CitationsSource
#1Min Hee Yang (Kyung Hee University)H-Index: 6
#2In Jin Ha (Kyung Hee University)H-Index: 1
Last. Kwang Seok Ahn (Kyung Hee University)H-Index: 56
view all 4 authors...
Albendazole (ABZ) has been reported to display anti-tumoral actions against various maliganncies, but possible impact of ABZ on gastric cancer has not been deciphered. As aberrant phosphorylation of STAT3 and STAT5 proteins can regulate the growth and progression of gastric cancer, we postulated that ABZ may interrupt the activation of these oncogenic transcription factors. We found that ABZ exposure abrogated STAT3/5 activation, inhibited phosphorylation of Janus-activated kinases 1/2 and Src a...
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#1Saeed AshrafizavehH-Index: 1
#2Milad Ashrafizadeh (Sabancı University)H-Index: 3
Last. Kwang Seok Ahn (Kyung Hee University)H-Index: 56
view all 12 authors...
Abstract Chemotherapy is the main treatment used for cancer patients failing surgery. Doxorubicin (DOX) is a well-known chemotherapeutic agent capable of suppressing proliferation in cancer cells and triggering apoptosis via inhibiting topoisomerase II activity and producing DNA breaks. This activity of DOX restrains mitosis and cell cycle progression. However, frequent application of DOX results in the emergence of resistance in the cancer cells. It seems that genetic and epigenetic factors can...
2 CitationsSource
#1Young Yun Jung (Kyung Hee University)H-Index: 6
#2In Jin Ha (Kyung Hee University)H-Index: 1
Last. Kwang Seok Ahn (Kyung Hee University)H-Index: 56
view all 5 authors...
Abstract Introduction The development of cancer generally occurs as a result of various deregulated molecular mechanisms affecting the genes that can control normal cellular growth. Signal transducer and activator of transcription 3 (STAT3) pathway, once aberrantly activated can promote carcinogenesis by regulating the transcription of a number of oncogenic genes. Objectives Here, we evaluated the impact of fangchinoline (FCN) to attenuate tumor growth and survival through modulation of oncogeni...
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