Shaheen Hamdy
University of Manchester
AnatomySwallowingInternal medicineSurgeryPsychologyNeuroscienceMotor systemPhysical therapyStimulationNeurostimulationOropharyngeal dysphagiaElectromyographyMotor cortexTranscranial magnetic stimulationDysphagiaLesionBrain stimulationAnesthesiaStrokeMedicinePhysical medicine and rehabilitation
300Publications
52H-index
7,442Citations
Publications 296
Newest
#1Satish S.C. Rao (Georgia Regents University)H-Index: 79
#2Yun Yan (Georgia Regents University)H-Index: 4
Last. Shaheen Hamdy (University of Manchester)H-Index: 52
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OBJECTIVES Translumbosacral neuromodulation therapy (TNT) improves symptoms of fecal incontinence (FI), but its mechanism of action is unknown. We tested the hypothesis that TNT at one or more frequency will significantly improve underlying pathophysiology of FI through modulation of ascending and/or descending signaling pathways in the gut and brain axis and anorectal sensorimotor function. MATERIALS AND METHODS We assessed afferent anorectal-cortical evoked potentials (CEP) following electrica...
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#1Anne Worthington (University of Manchester)H-Index: 1
#2Alise Kalteniece (University of Manchester)H-Index: 9
Last. Nigel A. Calcutt (UCSD: University of California, San Diego)H-Index: 58
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OBJECTIVE null Impaired rate-dependent depression of the Hoffman reflex (HRDD) is a marker of spinal inhibitory dysfunction and has previously been associated with painful neuropathy in a proof-of-concept study in patients with type 1 diabetes. We have now undertaken an assessment of HRDD in patients with type 1 or type 2 diabetes. null RESEARCH DESIGN AND METHODS null A total of 148 participants, including 34 healthy control subjects, 42 patients with painful diabetic neuropathy, and 62 patient...
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#1Mengqing Zhang (SYSU: Sun Yat-sen University)H-Index: 2
#2Ivy Cheng (Salford Royal NHS Foundation Trust)
Last. Shaheen Hamdy (Salford Royal NHS Foundation Trust)H-Index: 52
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BACKGROUND Transcranial alternating current stimulation (tACS) and transcranial random noise stimulation (tRNS) have been shown to have physiological and functional effects on brain excitability and motor behavior. Yet, little is known about their effects in the swallowing system. AIM To examine the effects and optimal stimulation parameters of tACS and tRNS for modulating excitability of human pharyngeal motor cortex. METHODS 10 Hz (alpha), 20 Hz (beta), 70 Hz (gamma) tACS, 0.1-640 Hz (full-spe...
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#1Jacqueline K. Benfield (University of Nottingham)H-Index: 3
#2Emilia Michou (University of Manchester)H-Index: 19
Last. Timothy J. England (University of Nottingham)H-Index: 26
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: Videofluoroscopy (VFS) is considered one of the gold-standard assessments of swallowing. Whilst guidelines for the application and conduct of VFS exist, their translation into clinical practice remain challenging. To build a greater understanding on how VFS clinics operate in the UK. A web-based survey was shared with speech and language therapists (SLTs) working in VFS clinics via professional networks and social media from October 2018 to January 2019. 101 responses were received. Two thirds...
1 CitationsSource
#1Ayodele Sasegbon (University of Manchester)H-Index: 4
#2Shaheen Hamdy (University of Manchester)H-Index: 52
Swallowing is a complex activity requiring a sophisticated system of neurological control from neurones within the brainstem, cerebral cortices and cerebellum. The cerebellum is a critical part of the brain responsible for the modulation of movements. It receives input from motor cortical and sensory areas and fine tunes these inputs to produce coordinated motor outputs. With respect to swallowing, numerous functional imaging studies have demonstrated increased activity in the cerebellum during ...
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#1Ayodele Sasegbon (University of Manchester)H-Index: 4
#2Nikola Niziolek (University of Manchester)H-Index: 1
Last. Shaheen Hamdy (University of Manchester)H-Index: 52
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We sought to compare the effects of 10 Hz cerebellar vermis (vs. unilateral hemispheric and sham) repetitive transcranial magnetic stimulation (rTMS) on cortical neuroelectrical activity and thereafter 10 Hz cerebellar vermis (vs. sham) rTMS on swallowing behaviour. Healthy participants (n = 25) were randomly allocated to receive vermis, unilateral hemisphere or sham 10 Hz cerebellar rTMS. Recordings were made using pharyngeal electromyography and manometry catheters, obtaining motor-evoked pote...
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#1Jin Magara (Niigata University)H-Index: 9
#2Masahiro Watanabe (Niigata University)H-Index: 5
Last. Makoto Inoue (Niigata University)H-Index: 25
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BACKGROUND Thermal tactile oropharyngeal stimulation has been clinically used to facilitate swallowing initiation in dysphagic patients. We previously demonstrated that thermal stimulation applied to the oral cavity provokes an immediate excitability in pharyngeal motor cortex. The aim of the current study was to investigate whether thermal stimulation can produce longer lasting effects on the corticopharyngeal neural pathway. METHODS Healthy volunteers (n = 8/12) underwent baseline pharyngeal m...
1 CitationsSource
#1Satish S.C. RaoH-Index: 79
#2Xuelian XiangH-Index: 3
Last. Shaheen Hamdy (University of Manchester)H-Index: 52
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Introduction Treatments for fecal incontinence (FI) remain unsatisfactory because they do not remedy the underlying multifactorial dysfunction(s) including anorectal neuropathy. The aim of this study was to investigate the optimal dose frequency, clinical effects, and safety of a novel treatment, translumbosacral neuromodulation therapy (TNT), aimed at improving neuropathy. Methods Patients with FI were randomized to receive 6 sessions of weekly TNT treatments consisting of 600 repetitive magnet...
1 CitationsSource
#1Ayodele SasegbonH-Index: 4
#2Craig J. SmithH-Index: 29
Last. Shaheen HamdyH-Index: 52
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