Min Suk Yang
Gyeongsang National University
CytotoxicityHorticultureCytotoxic T cellPharmacognosyOrganic chemistryStereoselectivityChemistryIn vitroSesquiterpeneSesquiterpene lactoneMethanolAntibacterial activityChloroformLignanChrysanthemum coronariumHemisteptia lyrataHuman cancerTerpeneAmino acidYield (chemistry)BiochemistryTraditional medicineBotanyAgronomyStereochemistryBiology
80Publications
15H-index
755Citations
Publications 76
Newest
#1Jun LeeH-Index: 12
#2Nan Hee KimH-Index: 13
Last. Jin Sook KimH-Index: 35
view all 10 authors...
Five compounds previously known structures, scopoletin (1), northalifoline (2), stigmast-4-en-3-one (3), tiliroside (4), and oplopanone (5) were obtained from the flower buds of Magnolia fargesii using chromatographic separation methods. The structures of 1–5 were identified by the interpretation of their spectroscopic data including 1D- and 2D-NMR as well as by comparison with reported values. Three compounds 1–3 were found from M. fargesii for the first time in this study. All the isolates (1–...
32 CitationsSource
#1Jun LeeH-Index: 11
#2Eun-Kyoung SeoH-Index: 25
Last. Jin Sook KimH-Index: 35
view all 10 authors...
Source
#1Jun LeeH-Index: 12
#2Eun-Kyoung Seo (Ewha Womans University)H-Index: 25
view all 10 authors...
A new stereoisomer of 8-0-4' system neolignan, (7R,8S)-1-(3,4-dimethoxyphenyl)-2-[4-(3-hydroxy-1-propenyl)-2-methoxyphenoxy]-propane-1,3-diol (1) and a new stereoisomer of tetrahydrofuranoid lignan, (7R,8S,7'S,8'R)-(3,4,5,3',4')-pentamethoxy-9,7'-dihydroxy-8.8',7.O.9'-lignan (2) along with seven known lignans and neolignans (3-9) were isolated from the methanol extracts of the flower buds of Magnolia fargesii. The structures of these compounds (1-9) were elucidated by spectroscopic methods inclu...
27 CitationsSource
#1Ki Hun Park (Gyeongsang National University)H-Index: 52
#2Min Suk Yang (Gyeongsang National University)H-Index: 15
Last. Jong Rok Lee (Daegu Haany University)H-Index: 18
view all 7 authors...
Abstract A new cytotoxic guaianolide was isolated from Chrysanthemum boreale Makino. The structure of guaianolide was elucidated as 8-acetoxy-4,10-dihydroxy-2,11(13)-guaiadiene-12,6-olide (1). Compound 1 exhibited cytotoxic activity (IC50 ≤ 4 µg/ml) against all five human cancer cell lines tested.
13 CitationsSource
#1Yoon-Su Baek (Gyeongsang National University)H-Index: 7
#2Young Bae Ryu (Gyeongsang National University)H-Index: 18
Last. Ki Hun Park (Gyeongsang National University)H-Index: 52
view all 7 authors...
Abstract Six 1,3-diphenylpropanes exhibiting inhibitory activities against both the monophenolase and diphenolase actions of tyrosinase were isolated from the methanol (95%) extract of Broussonetia kazinoki . These compounds, 1 – 6, were identified as kazinol C ( 1 ), D ( 2 ), F ( 3 ), broussonin C ( 4 ), kazinol S ( 5 ) and kazinol T ( 6 ). The latter two species ( 5 and 6 ) emerged to be new 1,3-diphenylpropanes which we fully spectroscopically characterized. The IC 50 values of compounds ( 1 ...
45 CitationsSource
#1Young Bae Ryu (Gyeongsang National University)H-Index: 18
Last. Ki Hun Park (Gyeongsang National University)H-Index: 52
view all 8 authors...
Pterocarpans (1-3) and flavanones (4-10) were isolated from Sophora flavescens and screened for their ability to inhibit neuraminidase (an enzyme crucial in the proliferation of the influenza virus). The major- ity of inhibitors were shown to have IC50 values of 20 lM or below. Interestingly, pterocarpan 1 emerged as the best inhibitor with an IC50 of 1.4 lM. We were thus able to prove that the pterocarpan skeleton is a new class of lead structure for neuraminidase inhibitors. Our studies reveal...
49 CitationsSource
#1Hyun Sook Kwon (Gyeongsang National University)H-Index: 4
#2Min Jung KimH-Index: 1
Last. Woo Song LeeH-Index: 17
view all 7 authors...
Abstract Six diarylbutane lignans 1 – 5 and one aryltetralin lignan 6 were isolated from the methanol (95%) extracts of Myristica fragrans seeds and then 7-methyl ether diarylbutane lignan 4 has proven to be new a compound. Their compounds 1 – 7 were evaluated for LDL-antioxidant activity to identify the most potent LDL-antioxidant 3 with an IC 50 value of 2.6 μM in TBARS assay. Due to its potency, compound 3 was tested for complementary in vitro investigations, such as lag time (140 min at 1.0 ...
34 CitationsSource
#1Oleg Yarishkin (Gyeongsang National University)H-Index: 17
#2Hyung Won Ryu (Gyeongsang National University)H-Index: 21
Last. Ki Hun Park (Gyeongsang National University)H-Index: 52
view all 6 authors...
Abstract Chalcone derivatives 1 – 17 were synthesized and their voltage-dependent K + channel inhibitory activities were investigated. The effective K + channel blockers were shown to be sulfonate chalcones 9 – 17 , in which the sulfonyloxy group is placed on the A-ring. The 3′-( p -aminobenzene-sulfonylhydroxy)-4-hydroxychalcone 17 (IC 50 = 0.51 ± 0.05 μM) was the most potent K + channel blocker.
46 CitationsSource
#1Jun Lee (Ewha Womans University)H-Index: 12
#2Dongho Lee (KU: Korea University)H-Index: 34
Last. Eun-Kyoung Seo (Ewha Womans University)H-Index: 25
view all 8 authors...
Two new stereoisomers of tetrahydrofuranoid lignans, 75,8R,7'S,8'R- (1) and 7R,8S,7'S,8'R-3,4,3',4'-tetramethoxy-9,7'-dihydroxy-8.8',7.0.9'-lignan (2) along with nine known lignans including tetrahydrofuranoids (3, 4) and tetrahydrofurofuranoids (5-11) were isolated from a CHCl 3 -soluble fraction of the flower buds of Magnolia fargesii. Two tetrahydrofuranoids, magnostellin A (3) and lariciresinol dimethyl ether (4) were isolated from this species for the first time. The structures of these com...
24 CitationsSource
#1Woo Duck SeoH-Index: 11
Last. Ki Hun ParkH-Index: 52
view all 6 authors...
Valine and alanine were converted into the corresponding α-hydroxy-β-amino acids through intramolecular S N 2' cyclization. The novel cyclization protocol relied upon the use of N-benzyl-protected carbamates derived from α-amino acids.
Source