Xing-Wei Yang
Chinese Academy of Sciences
CytotoxicityBioorganic chemistryCytotoxic T cellOrganic chemistryChemistryIndole testTerpenoidBicyclic moleculeAbsolute configurationIndole alkaloidAlstonia scholarisIC50HypericumHyperforinAdamantaneAntibacterial activityAbietaneTraditional medicineStereochemistryBiology
69Publications
17H-index
820Citations
Publications 59
Newest
#1Hai-Lian Yuan (CAS: Chinese Academy of Sciences)H-Index: 2
#2Yun-Li Zhao (Yunnan University)H-Index: 1
Last. Xiao-Dong Luo (CAS: Chinese Academy of Sciences)H-Index: 15
view all 6 authors...
Abstract Ethnopharmacological relevance Hypecoum erectum has been used extensively in folk medicine to treat inflammation, fever, and pain. However, few investigations have been carried out on the biological activities related to its traditional use. The chemical constituents of this plant along with their anti-inflammatory and analgesic effects have yet to be revealed. Aim of the study This study aimed to support the traditional use of H. erectum by first assessing its anti-inflammatory and ana...
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#1Hai-Lian Yuan (CAS: Chinese Academy of Sciences)H-Index: 2
#2Yun-Li Zhao (CAS: Chinese Academy of Sciences)H-Index: 12
Last. Xiao-Dong Luo (CAS: Chinese Academy of Sciences)H-Index: 15
view all 9 authors...
Abstract Ethnopharmacological relevance Neolamarckia cadamba has been used traditionally to treat inflammation, fever, and pruritus in the Dai ethnopharmacy in Yunnan province, P.R. China. However, according to literature survey, the action basis of anti-inflammatory and analgesic activities of this plant were rarely reported, which accounts for the original intentions of this investigation. Aim of the study The study aimed to investigate the anti-inflammatory and analgesic action of methanolic ...
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#1Wei-Di Chen (CAS: Chinese Academy of Sciences)H-Index: 1
#2Yun-Li Zhao (CAS: Chinese Academy of Sciences)H-Index: 12
Last. Xiao-Dong Luo (CAS: Chinese Academy of Sciences)H-Index: 15
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Clerodendranthus spicatus, popularly known as “kidney tea” in China, is consumed traditionally as a functional food for treatment of renal inflammation, dysuria, and gout. We evaluated the effects ...
3 CitationsSource
#1Xin Yi (Yunnan University)H-Index: 1
#2Zhi Dai (Yunnan University)H-Index: 2
Last. Xiao-Dong Luo (CAS: Chinese Academy of Sciences)H-Index: 15
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Sarcorusones A-D (1-4), four new androstane (C19-steroid) derivatives were characterized from Sarcococca ruscifolia along with five known compounds. Their structures were elucidated on the basis of extensive MS and NMR spectroscopic analysis. All the new structures share common 14-hydroxyl and 17-ketone functional groups, and compounds 2-4 feature a seneciamide group connecting to C-3 position. The inhibitory activities of all the isolates against melanoma cell B16F10 and lung cancer cell H1299 ...
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#1Robert B. Grossman (UK: University of Kentucky)H-Index: 23
#2Xing-Wei Yang (CAS: Chinese Academy of Sciences)H-Index: 17
Previously, Lin et al. reported the isolation and structural determination of two triterpenoids, garcinielliptin oxide (GO) and garcinielliptone E (GE). Their unusual structural features, which rem...
1 CitationsSource
#1Yan-Song Ye (CAS: Chinese Academy of Sciences)H-Index: 3
#2Man Wu (SHU: Shanghai University)H-Index: 7
Last. Gang Xu (CAS: Chinese Academy of Sciences)H-Index: 36
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A series of dearomatized isoprenylated acylphloroglucinols derivatives, hyperhenols A–E (1–5), as well as seven known analogues (6–12), were characterized from Hypericum henryi. Their structures were determined by combination of NMR, ECD spectroscopy, and X-ray diffraction analysis. Compounds 1 and 6–8 were tested to exhibit potential antitumor properties, of which 6 and 7 inhibited cell growth through inducing apoptosis and cell cycle arrest. In addition, these compounds could induce autophagy ...
3 CitationsSource
#1Xing-Wei Yang (CAS: Chinese Academy of Sciences)H-Index: 17
#2Robert B. Grossman (UK: University of Kentucky)H-Index: 23
Recently, a paper in this journal reported the isolation and structure determination of hypatulone A. Several features of the proposed structure and biosynthesis induced us to reexamine the compound’s NMR spectra. Now we propose a revised structure, confirm it with quantum computations, and suggest a reasonable radical-mediated biosynthetic pathway to the revised structure. Our work illustrates how both biosynthetic considerations and quantum computations can complement spectroscopic structure d...
2 CitationsSource
#1Na-Na Jiang (CAS: Chinese Academy of Sciences)H-Index: 1
#2Shu-Zong Du (KIZ: Kunming Institute of Zoology)H-Index: 1
Last. Gang Xu (CAS: Chinese Academy of Sciences)H-Index: 36
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Abstract Hyphenone A (1), a new type of bicyclic polyprenylated acylphloroglucinols (BPAPs) featured with an unprecedented 3,3-diisoprenylated 1,3,5-trione core, were characterized from the roots of Hypericum henryi together with two new congeners (hyphenones B–C, 2–3) and five known biosynthetic related PPAPs. Biogenetically, 1 should be derived from a novel 3,3,5,5-tetraisoprenylated MPAPs precursor. Their structures were elucidated by comprehensive spectroscopic data and X-ray diffraction. Mo...
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#1Xin-Wen Zhang (CAS: Chinese Academy of Sciences)H-Index: 2
#2Yan-Song Ye (CAS: Chinese Academy of Sciences)H-Index: 3
Last. Gang Xu (CAS: Chinese Academy of Sciences)H-Index: 36
view all 5 authors...
In the original publication the corresponding author appeared incorrectly as Xin-Wen Zhang. The corrected text is given below: The corresponding author of the article is Gang Xu.
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#1Fan Xia (CAS: Chinese Academy of Sciences)H-Index: 5
#2Wen-Yan Li (KIZ: Kunming Institute of Zoology)H-Index: 2
Last. Gang Xu (CAS: Chinese Academy of Sciences)H-Index: 36
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Salpratlactones A (1) and B (2), a pair of abietane cis–trans tautomers from Salvia prattii, were identified as the first naturally occurring agonists of T-type calcium channel (TTCC). Structurally, 1 and 2 were featured by unique 6/5 carbocyclic rings bearing a γ-lactone ring through an exocyclic double bond. Moreover, both compounds and their mixture at 10 μM potently and equally increased Cav3.1 TTCC peak currents, and 1 had an EC50 value of 12.48 μM.
4 CitationsSource
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