Jiyuan Zhao
University of Tokyo
Regenerative medicineBone morphogenetic protein 7Bone cellEndocrinologyCellular differentiationChemistryIn vivoRUNX2OsteoblastType I collagenIcariinBone morphogenetic protein 4ImplantTransplantationBone regenerationBone morphogenetic protein 2Bone morphogenetic proteinScaffoldCell biologyPharmacology
3Publications
3H-index
232Citations
Publications 3
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#1Jiyuan Zhao (UTokyo: University of Tokyo)H-Index: 3
#2Shinsuke OhbaH-Index: 32
Last. Teruyuki NagamuneH-Index: 39
view all 6 authors...
To effectively treat bone diseases using bone regenerative medicine, there is an urgent need to develop safe and cheap drugs that can potently induce bone formation. Here, we demonstrate the osteogenic effects of icariin, the main active compound of Epimedium pubescens. Icariin induced osteogenic differentiation of preosteoblastic cells. The combination of icariin and a helioxanthin-derived small compound synergistically induced osteogenic differentiation of MC3T3-E1 cells to a similar extent to...
96 CitationsSource
#1Jiyuan Zhao (UTokyo: University of Tokyo)H-Index: 3
#2Masashige Shinkai (UTokyo: University of Tokyo)H-Index: 8
Last. Teruyuki Nagamune (UTokyo: University of Tokyo)H-Index: 39
view all 6 authors...
Abstract Bone morphogenetic protein-2 is a very promising candidate for the treatment of bone diseases and defects, but more effective therapeutic methods are required due to its instability in vivo . A controlled and localized delivery system of Bone morphogenetic protein-2 would be appropriate for effective bone regeneration. Here, we report a novel delivery system of bone morphogenetic protein-2 using vitrigel (a novel stable collagen gel membrane prepared from vitrified type I collagen) for ...
62 CitationsSource
#1Jiyuan Zhao (UTokyo: University of Tokyo)H-Index: 3
#2Shinsuke Ohba (UTokyo: University of Tokyo)H-Index: 32
Last. Teruyuki Nagamune (UTokyo: University of Tokyo)H-Index: 39
view all 5 authors...
To effectively treat bone diseases using bone regenerative medicine, there is an urgent need to develop safe cheap drugs that can potently induce bone formation. Here, we demonstrate the osteogenic effect of icariin, the main active compound of Epimedium pubescens. Icariin induced osteogenic differentiation in pre-osteoblastic MC3T3-E1 cells and mouse primary osteoblasts. Icariin upregulated the mRNA expression levels of the osteoblast marker genes runt-related transcription factor 2 (Runx2) and...
193 CitationsSource
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