Zhen-Biao Zhang
Guangzhou University of Chinese Medicine
Vascular permeabilityTumor necrosis factor alphaChemistryApoptosisImmunologyIn vivoSuperoxide dismutaseOxidative stressBleomycinInflammationMetaboliteNF-?BProstaglandin E2AntioxidantCurcuminI?BaEdemaPulmonary fibrosisAndrographolideToxicityGlutathioneBiochemistryMedicinePharmacology
22Publications
14H-index
428Citations
Publications 22
Newest
#1Zhen-Biao Zhang (Guangzhou University of Chinese Medicine)H-Index: 14
#2Dandan Luo (Guangzhou University of Chinese Medicine)H-Index: 12
Last. Zi-Ren Su (Guangzhou University of Chinese Medicine)H-Index: 30
view all 11 authors...
Curcumin (CUR), a promising naturally-occurring dietary compound, is commonly recognized as the potential anti-inflammatory agent. While the application of CUR was hampered by its low stability and poor systemic bioavailability, it has been suggested that the biological activities of CUR are intimately related to its metabolites. In the current investigation, we aimed to comparatively explore the anti-inflammatory effects of tetrahydrocurcumin (THC), octahydrocurcumin (OHC) and CUR, and to eluci...
32 CitationsSource
#1Juan Nie (Guangzhou University of Chinese Medicine)H-Index: 4
#2Hongmei Yang (Guangzhou University of Chinese Medicine)H-Index: 8
Last. Yu-Cui Li (Guangzhou University of Chinese Medicine)H-Index: 20
view all 9 authors...
Bleomycin (BLM), a broad spectrum anti-tumor drug, have side effects of inducing pulmonary fibrosis. As an anti-tumor drug without immunosuppression, it is urgent to find a drug that reduces the side effects of BLM. Scutellarin (SCU), a flavone extracted from Erigeron breviscapus (Vant.) Hand-Mazz, has anti-inflammatory activity and ability to inhibit tumor cell growth, migration and invasion. However, the combined role of SCU and BLM treatment in tumor is unclear. This study aimed to investigat...
12 CitationsSource
#1Zhen-Biao Zhang (Guangzhou University of Chinese Medicine)H-Index: 14
#2Dandan Luo (Guangzhou University of Chinese Medicine)H-Index: 12
Last. Jianping ChenH-Index: 15
view all 10 authors...
The biological activity of curcumin (CUR), a promising naturally occurring dietary compound for the treatment of hepatocellular carcinoma (HCC), was closely associated with its metabolite. Octahydrocurcumin (OHC) is the final hydrogenated metabolite of CUR and has been reported to have potential biological activities. However, difficulties in access have hampered its biological studies. In the current investigation, we designed an efficient synthesis method to produce OHC, and comparatively expl...
13 CitationsSource
#1Weihai LiuH-Index: 2
#2Zhen-Biao Zhang (Guangzhou University of Chinese Medicine)H-Index: 14
Last. Hongying Cao (Guangzhou University of Chinese Medicine)H-Index: 1
view all 11 authors...
Curcumin (CUR), a widely used food additive, is derived mainly from Curcuma species that has been applied traditionally for the treatment of various diseases, including hepatocellular carcinoma (HCC). However, its poor systemic bioavailability hampers its clinical application, which may be related to its wide metabolism. Tetrahydrocurcumin (THC) is a major metabolite of CUR and has been reported to have multiple biologic activities. We investigated, for the first time, the efficacy and associate...
15 CitationsSource
#1Hanbin Chen (Guangzhou University of Chinese Medicine)H-Index: 9
#2Chaodan Luo (Guangzhou University of Chinese Medicine)H-Index: 6
Last. Hui-Fang Zeng (Guangzhou University of Chinese Medicine)H-Index: 14
view all 12 authors...
Abstract Coptisine is one of the main constituents of Coptis chinensis which has been widely used for the remedy of inflammatory disorders. Although the biological activities of coptisine have been well known, the pharmacological properties of its free base have seldomly been elucidated thus far. The aim of this study was to investigate the potential anti-inflammatory properties of coptisine free base (CFB, 8-hydroxy-7,8-dihydrocoptisine) on three animal models, namely xylene-induced ear edema, ...
33 CitationsSource
#1Xiao-Ying Chen (Guangzhou University of Chinese Medicine)H-Index: 10
#2Yao-Xing Dou (Guangzhou University of Chinese Medicine)H-Index: 9
Last. Yu-Cui Li (Guangzhou University of Chinese Medicine)H-Index: 20
view all 10 authors...
Abstract β-Patchoulene (β-PAE), a tricyclic sesquiterpene isolated from the essential oil of the leaves and stems of Pogostemon cablin ( Blanco ) Benth ., has been reported to have potent anti-inflammatory activity. The aim of this study was to evaluate the potential protective effect of β-PAE on lipopolysaccharide (LPS)-induced acute lung injury (ALI) in mice and to illuminate the underlying mechanisms. ALI was induced by intracheal instillation of LPS into lung, and dexamethasone (DEX) was use...
22 CitationsSource
#1Jia-Li Liang (Guangzhou University of Chinese Medicine)H-Index: 11
#2Jia-Zhen Wu (Guangzhou University of Chinese Medicine)H-Index: 9
Last. Janis Ya-Xian ZhanH-Index: 10
view all 11 authors...
According to the GC-MS analysis, compositional variation was observed between samples of patchouli oil, of which an unknown compound identified as patchoulene epoxide (PAO) was found only in the long-stored oil, whose biological activity still remains unknown. Therefore, the present study aimed to evaluate the potential anti-inflammatory activity with three in vivo inflammatory models: xylene-induced ear edema, acetic acid-induced vascular permeability, and carrageenan-induced paw edema. Further...
12 CitationsSource
#1Yu-Hong Liu (Guangzhou University of Chinese Medicine)H-Index: 19
#2Jia-Li Liang (Guangzhou University of Chinese Medicine)H-Index: 11
Last. Yu-Cui Li (Guangzhou University of Chinese Medicine)H-Index: 20
view all 10 authors...
Pogostemonis Herba is a functional food approved in Asian countries. Its major constituent, patchouli alcohol (PA), possesses a gastroprotective effect and is reported to transform into β-patchoulene (β-PAE) under acidic conditions. To investigate whether β-PAE, the metabolite of PA, has a protective effect on the gastrointestinal tract, the formation of β-PAE by gastric juice and the anti-ulcerogenic potential of β-PAE against ethanol-induced gastric injury were evaluated. The Results indicated...
22 CitationsSource
#1Dandan Luo (Guangzhou University of Chinese Medicine)H-Index: 12
#2Cao QuH-Index: 1
Last. Zi-Ren Su (Guangzhou University of Chinese Medicine)H-Index: 30
view all 10 authors...
Abstract Dendrobium officinale was separated into total polysaccharides (DOP) and supernatant (DOS) to investigate the laxative ingredients and mechanism in normal and constipated mice induced by diphenoxylate or water fasting. The molecular weight and components of DOP were determined by HPGPC, HPLC and LC-MS. DOP was mainly composed of d -mannose (59.19 mg/g) and d -glucose (830.98 mg/g), with a molecular weight of 8404 Da. DOP (29, 57, 114 mg/kg, i.g.) exhibited an appreciable laxative effect...
19 CitationsSource
#1Guanghua Yang (Guangzhou University of Chinese Medicine)H-Index: 4
#2Lan Wang (Guangzhou University of Chinese Medicine)H-Index: 5
Last. Haiming ChenH-Index: 15
view all 12 authors...
Triptolide (TP) is the major active component of Tripterygium wilfordii Hook F (TWHF) and possesses multiple pharmacological effects. However, hepatotoxicity of TP which is one of the toxic properties slows its progression in clinical application. 18β-Glycyrrhetinic acid (GA) is the main bioactive ingredient of Licorice (Glycyrrhiza glabra L.), a herbal medicine famous for its detoxification. This study aims to investigate whether GA possesses protective effect against TP-induced hepatotoxicity ...
10 CitationsSource