Zhongyue Luo
University of Minnesota
ProteomeCancerPathologyPDZ domainRNA interferenceStromal cellChemistryDNA methylationChinaImmunohistochemistryMicrovesiclesIn vivoMetabolomicsTumor microenvironmentInflammationMolecular oncologyCarcinomaSerous carcinomaLeiomyomaMetastasisAdenomyosisEndometriosisEndometriumOvarian cancerPathogenesisDebulkingTargeted therapyGynecological disordersExtracellular matrix componentGynecologyCell cycleMass spectrometricUniversity hospitalWest chinaProteomicsFibroblast growth factor receptor 1Cancer researchFamily medicineChristian ministryColorectal cancerTraditional medicineBioinformaticsSignal transductionCandidate geneMedicineEpithelial–mesenchymal transitionFibroblast growth factor receptorBiologyCancer cell
Publications 6
#1Linjie Zhao (Sichuan University)H-Index: 15
#2G Ji (Sichuan University)H-Index: 1
Last. Shengtao Zhou (Sichuan University)H-Index: 23
view all 21 authors...
Abstract Epithelial ovarian cancer (EOC) is one of the most common gynecological cancers, with diagnosis often at a late stage. Metastasis is a major cause of death in patients with EOC, but the underlying molecular mechanisms remain obscure. Here, we utilized an integrated approach to find potential key transcription factors involved in ovarian cancer metastasis and identified STAT4 as a critical player in ovarian cancer metastasis. We found that activated STAT4 was overexpressed in epithelial ...
32 CitationsSource
#1Huiliang Yang (Sichuan University)H-Index: 8
#2Wayne Bond Lau (Thomas Jefferson University Hospital)H-Index: 41
Last. Yuquan Wei (Sichuan University)H-Index: 85
view all 11 authors...
Applications of mass spectrometry (MS) are rapidly expanding and encompass molecular and cellular biology. MS aids in the analysis of in vivo global molecular alterations, identifying potential biomarkers which may improve diagnosis and treatment of various pathologies. MS has added new dimensionality to medical research. Pioneering gynecologists now study molecular mechanisms underlying female reproductive pathology with MS-based tools. Although benign gynecologic disorders including endometrio...
8 CitationsSource
#1Yanfei Yang (Sichuan University)H-Index: 3
#2Linjie Zhao (Sichuan University)H-Index: 15
Last. Shengtao ZhouH-Index: 23
view all 19 authors...
// Yanfei Yang 1, * , Linjie Zhao 1, * , Lingzi Lei 1, * , Wayne Bond Lau 2, * , Bonnie Lau 3, * , Qilian Yang 1 , Xiaobing Le 1 , Huiliang Yang 4 , Chenlu Wang 5 , Zhongyue Luo 5 , Yu Xuan 1 , Yi Chen 6 , Xiangbing Deng 6 , Lian Xu 7 , Min Feng 7 , Tao Yi 1 , Xia Zhao 1 ,Yuquan Wei 1 , Shengtao Zhou 1 1 Department of Obstetrics and Gynecology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education, West China Second Hospital and State Key Laboratory ...
20 CitationsSource
#1Zhongyue Luo (Sichuan University)H-Index: 6
#2Qiu Wang (Sichuan University)H-Index: 1
Last. Shengtao Zhou (Sichuan University)H-Index: 23
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Abstract Despite chemotherapy and surgical debulking options, ovarian cancer recurs and disseminates frequently, with poor prognosis. However, the molecular mechanisms underlying ovarian cancer metastasis still remain unelucidated. The tumor microenvironment, consisting of stromal cells (including fibroblasts, macrophages, regulatory T cells, myeloid-derived suppressor cells, endothelial cells, pericytes and platelets), the extracellular matrix component (EMC) (including inflammatory cytokines, ...
70 CitationsSource
#1Linjie ZhaoH-Index: 15
#2Chuan YuH-Index: 6
Last. Yuquan WeiH-Index: 85
view all 12 authors...
// Linjie Zhao 1,2* , Chuan Yu 1,2* , Shengtao Zhou 1,2* , Wayne Bond Lau 3 , Bonnie Lau 4 , Zhongyue Luo 5 , Qiao Lin 5 , Huiliang Yang 6 , Yu Xuan 1,2 , Tao Yi 1,2 , Xia Zhao 1,2 and Yuquan Wei 1,2 1 Department of Gynecology and Obstetrics, Key Laboratory of Obstetrics & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second Hospital, Chengdu, China 2 The State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China 3 Depa...
14 CitationsSource
#1Linjie Zhao (Sichuan University)H-Index: 15
#2Huiliang Yang (Sichuan University)H-Index: 8
Last. Xia Zhao (Sichuan University)H-Index: 58
view all 9 authors...
Abstract Objective(s) This study aims to identify a critical molecule that potentially participates in endometriosis pathogenesis and characterize its correlation with dysmenorrhea and recurrence. Study design We utilized a bioinformatics-based strategy to screen for candidate genes and fibroblast growth factor receptor 1(FGFR1) was chosen for further validation. FGFR1 expression was examined in specimens of ectopic and eutopic endometrium obtained from 48 patients with endometriosis and specime...
8 CitationsSource