Qi-Hai Gong
Zunyi Medical College
EndocrinologyTumor necrosis factor alphaChemistryApoptosisNeuroprotectionOxidative stressInflammationMitochondrial ROSReperfusion injuryIcariinHippocampusAmyloid precursor proteinMorris water navigation taskNitric oxideIschemiaSignal transductionMedicineNeuroinflammationCell biologyPharmacology
64Publications
21H-index
1,373Citations
Publications 57
Newest
#1Na LiH-Index: 1
Last. Qi-Hai GongH-Index: 21
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Trilobatin (TLB) is an effective component of Lithocarpus polystachyrus Rehd. Our previous study revealed that TLB protected against oxidative injury in neuronal cells by AMPK/Nrf2/SIRT3 signaling pathway. However, whether TLB can delay aging remains still a mystery. Therefore, the present study was designed to investigate the possible longevity-enhancing effect of TLB, and further to explore its underlying mechanism in Caenorhabditis elegans (C. elegans). The results showed that TLB exerted ben...
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#1Yuanyuan DengH-Index: 12
Last. Qi-Hai GongH-Index: 21
view all 6 authors...
Reperfusion therapy is an effective way to rescue cerebral ischemic injury, but this therapy also shows the detrimental risk of devastating disorders and death due to the possible inflammatory responses involved in the pathologies. Hence, the therapy of ischemia/reperfusion (I/R) injury is a great challenge currently. Isorhynchophylline (IRN), a tetracyclic oxindole alkaloid extracted from U. rhynchophylla, has previously shown neuroprotective and anti-inflammatory effects in microglial cells. T...
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#1Yi-Qi Li (Ministry of Education)
#1Yi-qi Li (Ministry of Education)H-Index: 4
Last. Danli Yang (Ministry of Education)H-Index: 7
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Abstract: Percutaneous coronary intervention (PCI) is the most widely used therapy for treating ischemic heart disease. However, intimal hyperplasia and restenosis usually occur within months after angioplasty. Modern pharmacological researchers have proven that osthole, the major active coumarin of Cnidium monnieri (L.) Cusson, exerts potent antiproliferative effects in lung cancer cells, the human laryngeal cancer cell line RK33 and TE671 medulloblastoma cells and that its mechanism of action ...
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#1Jianmei GaoH-Index: 9
#2Nana ChenH-Index: 2
Last. Qihai GongH-Index: 1
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AIMS: Neuroinflammation and oxidative stress are deemed the prime causes of brain injury after cerebral ischemia-reperfusion (I/R). Since Sirt3 pathway plays an imperative role in protecting against neuroinflammation and oxidative stress and has been verified as a target to treat ischemia stroke. Therefore, we desired to seek novel Sirt3 agonist and explore its underlying mechanism for stroke treatment both in vivo and in vitro. RESULTS: Trilobatin (TLB) not only dramatically suppressed neuroinf...
7 CitationsSource
#1Mu-Bo LiuH-Index: 1
#2Wei WangH-Index: 2
Last. Qi-Hai GongH-Index: 21
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Cerebral ischemia/reperfusion (I/R) results in harmful consequences during ischemic stroke, especially the disruption of the blood–brain barrier (BBB), which leads to severe hemorrhagic transformation through aggravation of edema and brain hemorrhage. Our previous study demonstrated that icariside II (ICS II), which is derived from Herba Epimedii, attenuates cerebral I/R injury by inhibiting the GSK-3β-mediated activation of autophagy both in vitro and in vivo. However, the effect of ICS II on t...
4 CitationsSource
#1Nana ChenH-Index: 2
#2Jiao WangH-Index: 1
Last. Jianmei GaoH-Index: 9
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Emerging evidence reveals that an aberrant accumulation of β-amyloid (Aβ) is the main reason of Alzheimer's disease (AD) pathogenesis. Thus inhibition of Aβ-induced neurotoxicity may be promising therapeutic tactics to mitigate AD onset and advance. The development of agent candidates by cultured neurons against Aβ-induced cytotoxicity is widely accepted to be an efficient strategy to explore the drug for AD patients. Previously, we have revealed that trilobatin (TLB), a small molecule monomer, ...
4 CitationsSource
#1Fan XuH-Index: 3
#2Chun LvH-Index: 1
Last. Jianmei GaoH-Index: 9
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Background: Ischemic stroke remains the leading cause of death and adult disability. Cerebral ischemic/reperfusion (I/R) injury is caused by ischemic stroke thereafter aggravates overwhelming neuronal apoptosis and even death. Of note, hippocampus is more susceptive to cerebral I/R injury than the other brain region. In this study, the effects and mechanism of icariside II (ICS II), a pharmacologically active compound exists in herbal Epimedii with previous study-proved as a phosphodiesterase 5 ...
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#1Jianmei GaoH-Index: 9
#2Long LongH-Index: 1
Last. Qihai GongH-Index: 1
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BACKGROUND AND PURPOSE: Cerebral ischaemia/reperfusion causes exacerbated neuronal damage involving excessive autophagy and neuronal loss. The present study was designed to investigate the effect of icariside II, one of main active ingredients of Herba Epimedii on this loss and whether this is related to its PDE 5 inhibitory action. EXPERIMENTAL APPROACH: Focal cerebral ischaemia was induced in the rat by transient middle cerebral artery occlusion over 2 hr, followed by reperfusion with icarisid...
8 CitationsSource
#2Yan DengH-Index: 1
Last. Qi-Hai GongH-Index: 21
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β-amyloid (Aβ) is one of the inducing factors of astrocytes activation and neuroinflammation, and it is also a crucial factor for the development of Alzheimer’s disease (AD). Icariside II (ICS II) is an active component isolated from a traditional Chinese herb Epimedium, which has shown to attnuate lipopolysaccharide (LPS)-induced neuroinflammation through regulation of NF-κB signaling pathway. In this study we investigated the effects of ICS II on LPS-induced astrocytes activation and Aβ accumu...
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