Artur M. S. Silva
University of Aveiro
Reactivity (chemistry)Medicinal chemistryCatalysisCarbon-13 NMROrganic chemistryChemistryTwo-dimensional nuclear magnetic resonance spectroscopyCombinatorial chemistryAntioxidantChromonePorphyrinCycloadditionRing (chemistry)ArylMoleculeBiochemistryNuclear magnetic resonance spectroscopyStereochemistryPhotochemistryBiology
Publications 830
Last. Jean-Bernard Behr (URCA: University of Reims Champagne-Ardenne)H-Index: 15
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Abstract A series of 6H,7H-7-(4-Hydroxy-3-coumarinyl)[1]benzopyrano[4,3-b][1]benzopyran-6-ones 4a-g and 3-(2-hydroxybenzoyl)-2H-chromen-2-ones 5a-g derivatives were synthesized by reaction of 4-hydroxycoumarin with 2-hydroxyarylaldehydes 2a-f or 2-hydroxynaphtaldehyde 2g using different solvents and acid/base catalysts. The approach relies on a regioselective cascade reaction involving one/two molar equiv of the 4-hydroxy coumarin iteratively acting as active methylene substrate in a Knoevenagel...
#1Soraia P. S. Fernandes (University of Aveiro)H-Index: 5
#2Petr Kovář (Charles University in Prague)H-Index: 11
Last. Begoña EspiñaH-Index: 17
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Microcystins (MCs), produced by Microcystis sp, are the most commonly detected cyanotoxins in freshwater, and due to their toxicity, worldwide distribution, and persistence in water, an improvement in the monitoring programs for their early detection and removal from water is necessary. To this end, we investigate the performance of three covalent organic frameworks (COFs), TpBD-(CF3)2, TpBD-(NO2)2, and TpBD-(NH2)2, for the adsorption of the most common and/or toxic MC derivatives, MC-LR, MC-RR,...
#1Daniela Malafaia (University of Aveiro)H-Index: 1
#2Hélio Albuquerque (University of Aveiro)H-Index: 8
Last. Artur M. S. Silva (University of Aveiro)H-Index: 46
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Abstract Alzheimer’s disease (AD) is one of the most common types of dementia, especially in elderly, with an increasing number of people suffering of this disease worldwide. There are no available disease-modifying therapies and only four drugs are approved for the relief of symptoms. Currently, the therapeutic approach used for AD treatment is based on single target drugs, which are not capable of stopping its progression. To address this issue, multi-target compounds, combining two or more ph...
2 CitationsSource
#1Mariana P. MonteiroH-Index: 19
#1Mariana Monteiro (University of Aveiro)H-Index: 1
Last. Susana M. CardosoH-Index: 20
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Oleuropein (OLE) and hydroxytyrosol (HT) are olive-derived phenols recognised as health-promoting agents with antioxidant, anti-inflammatory, cardioprotective, antifungal, antimicrobial, and antitumor activities, providing a wide range of applications as functional food ingredients. HT is Generally Recognised as Safe (GRAS) by the European Food Safety Authority (EFSA) and the Food and Drug Administration (FDA), whereas OLE is included in EFSA daily consumptions recommendations, albeit there is n...
#1Drifa Belkhir-Talbi (University of Boumerdes)
#2Naima Ghemmit-Doulache (University of Boumerdes)
Last. Artur M. S. Silva (University of Aveiro)H-Index: 46
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Abstract Coordination compounds of N,N’-di(4-bromophenyl)-4-hydroxycoumarin-3-carboximidamide (L1) were synthesized via the reaction of Cu (II), Co (II) and Zn (II) salts in molar ratio 1 : 1 in the presence of ammoniac as basic media. The Ligands and the complexes formed were characterized using FT-IR, UV-visible and fluorescence spectrophotometric analyses, mass spectrometry, elemental analyses and NMR spectroscopy. It was concluded that N,N’-di(4-bromophenyl)-4-hydroxycoumarin-3-carboximidami...
#1Giusi Piccirillo (UC: University of Coimbra)H-Index: 2
#2Matilde Moreira-Santos (UC: University of Coimbra)H-Index: 21
Last. Mário J. F. Calvete (UC: University of Coimbra)H-Index: 27
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Abstract The preparation of covalently linked manganese(III) meso-tetrakis(2,6-dichlorophenyl)porphyrin acetate to aminopropyl functionalized silica gel and its full characterization by standard spectroscopic methods including Fourier transform infrared spectroscopy (FTIR), thermogravimetry (TG) and scanning electronic microscopy (SEM) is described. The supported metalloporphyrin was evaluated as catalyst in the degradation of trimethoprim (TMP), using hydrogen peroxide as green oxidant. Catalys...
2 CitationsSource
#2Decha KumlaH-Index: 4
Last. Anake KijjoaH-Index: 27
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Abstract Four undescribed prenylated phenylbutyrolactones, aspulvinones R, S, T and U, were isolated together with the previously reported aspulvinones A, B′, H and 4-hydroxy-3,5-bis(3-methylbut-2-en-1-yl)benzaldehyde, from cultures of the marine sponge-derived fungus Aspergillus flavipes KUFA1152. The structures of the undescribed compounds were established on the basis of extensive analysis of 1D and 2D NMR and HRMS spectra. In the case of aspulvinone T, the absolute configuration of its stere...
#1Maria Celeste Dias (University of Aveiro)H-Index: 18
#2Diana C. G. A. Pinto (University of Aveiro)H-Index: 27
Last. Artur M. S. Silva (University of Aveiro)H-Index: 46
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Abstract The frequency of combined stress events is increasing due to climate change and represents a new threat to olive (Olea europaea) culture. How olive plants modulate their profile of metabolites under multiple stressing agents remains to unveil, although several metabolites affect plants' resilience, and olive production and quality. Young olive plants were exposed to a water deficit (WD) for 30 days and then exposed to a shock of heat and high UVB-radiation (WDHS+UVB treatment) for 2 day...
#1Hélio AlbuquerqueH-Index: 8
Last. Artur M. S. SilvaH-Index: 46
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#1Diana C. G. A. Pinto (University of Aveiro)H-Index: 27
#2Artur M. S. Silva (University of Aveiro)H-Index: 46
The medicinal use and/or use in the nutrition of plants growing in Portugal is common, although in many cases the validation of their health benefits is far away from being established. On the other hand, other plants have a high impact on the country’s economy and are at risk of being damaged by climate changes, a factor that should also be evaluated. In this context, several research works were undertaken to establish the potential health or nutritional value of Calendula species, Pterospartum...
2 CitationsSource
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